| 1 | Mon Nov 7 | vs TBD | W75-42 | 1-0 | 1.000 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 2 | Fri Nov 11 | at Vanderbilt | W60-48 | 2-0 | 1.000 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 3 | Mon Nov 14 | vsTBD | W86-62 | 3-0 | 1.000 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 4 | Fri Nov 18 | at Liberty | W76-72 | 4-0 | 1.000 | - | | Liberty Arena · Lynchburg, VA |
| 5 | Tue Nov 22 | at Winthrop | W77-52 | 5-0 | 1.000 | - | | Winthrop Coliseum · Rock Hill, SC |
| 6 | Wed Nov 23 | vs Purdue FW | W70-58 | 6-0 | 1.000 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 7 | Sun Nov 27 | vsTBD | W103-52 | 7-0 | 1.000 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 8 | Tue Nov 29 | vs Montana | W64-54 | 8-0 | 1.000 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 9 | Sun Dec 4 | at N'Western St | L82-84 | 8-1 | .889 | - | | Prather Coliseum · Natchitoches, LA |
| 10 | Sat Dec 10 | vs Lamar | W95-59 | 9-1 | .900 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 11 | Tue Dec 13 | atLamar | W91-65 | 10-1 | .909 | - | | Montagne Center · Beaumont, TX |
| 12 | Sun Dec 18 | vs McNeese | W86-67 | 11-1 | .917 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 13 | Thu Dec 22 | at UNLV | L63-74 | 11-2 | .846 | - | | Thomas & Mack Center · Las Vegas, NV |
| 14 | Thu Dec 29 | vs Troy | W64-60 | 12-2 | .857 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 15 | Sat Dec 31 | vs Appalachian St | W76-70 | 13-2 | .867 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 16 | Thu Jan 5 | at Louisiana | L61-75 | 13-3 | .813 | - | | Cajundome · Lafayette, LA |
| 17 | Sat Jan 7 | at UL Monroe | W65-60 | 14-3 | .824 | - | | Fant-Ewing Coliseum · Monroe, LA |
| 18 | Thu Jan 12 | at Marshall | L67-89 | 14-4 | .778 | - | ESPN2 | Cam Henderson Center · Huntington, WV |
| 19 | Sat Jan 14 | at Arkansas St | W74-57 | 15-4 | .789 | - | | First National Bank Arena · Jonesboro, AR |
| 20 | Thu Jan 19 | vs South Alabama | W76-72 | 16-4 | .800 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 21 | Sat Jan 21 | vs JMU | W83-70 | 17-4 | .810 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 22 | Thu Jan 26 | vsArkansas St | W73-57 | 18-4 | .818 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 23 | Sat Jan 28 | vs Texas St | W67-58 | 19-4 | .826 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 24 | Thu Feb 2 | atTroy | W74-65 | 20-4 | .833 | - | | Trojan Arena · Troy, AL |
| 25 | Sat Feb 4 | at Georgia St | W79-71 | 21-4 | .840 | - | | GSU Convocation Center · Atlanta, GA |
| 26 | Thu Feb 9 | vsLouisiana | W82-71 | 22-4 | .846 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 27 | Sat Feb 11 | vsUL Monroe | W76-67 | 23-4 | .852 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 28 | Thu Feb 16 | atSouth Alabama | L54-85 | 23-5 | .821 | - | | Mitchell Center · Mobile, AL |
| 29 | Sat Feb 18 | vs Georgia So | W73-62 | 24-5 | .828 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 30 | Wed Feb 22 | at Old Dominion | L64-69 | 24-6 | .800 | - | | Chartway Arena · Norfolk, VA |
| 31 | Fri Feb 24 | atTexas St | W79-69 | 25-6 | .806 | - | | Strahan Arena at the University Events Center · San Marcos, TX |
| 32 | Sat Mar 4 | vsSouth Alabama | L61-78 | 25-7 | .781 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 33 | Tue Mar 14 | at UAB | L60-88 | 25-8 | .758 | - | | Bartow Arena · Birmingham, AL |
