| 1 | Tue Nov 9 | vs TBD | W81-67 | 1-0 | 1.000 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 2 | Fri Nov 12 | vs Louisiana | L45-66 | 1-1 | .500 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 3 | Mon Nov 15 | at TCU | L51-83 | 1-2 | .333 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 4 | Sun Nov 21 | vs Lamar | W82-75 | 2-2 | .500 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 5 | Wed Nov 24 | at UNC Wilmington | W80-66 | 3-2 | .600 | - | | Trask Coliseum · Wilmington, NC |
| 6 | Thu Nov 25 | vs UC San Diego | W56-55 | 4-2 | .667 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 7 | Fri Nov 26 | at Montana | L62-74 | 4-3 | .571 | - | | Dahlberg Arena · Missoula, MT |
| 8 | Wed Dec 1 | at South Alabama | L55-85 | 4-4 | .500 | - | | Mitchell Center · Mobile, AL |
| 9 | Sat Dec 4 | at S Illinois | L41-66 | 4-5 | .444 | - | | Banterra Center · Carbondale, IL |
| 11 | Tue Dec 14 | vs Jacksonville | L51-62 | 4-6 | .400 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 12 | Sat Dec 18 | at UL Monroe | L65-74 | 4-7 | .364 | - | | Fant-Ewing Coliseum · Monroe, LA |
| 13 | Tue Dec 21 | at E Carolina | L67-68 | 4-8 | .333 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 14 | Thu Dec 30 | vs Western KY | PPD | 7-26 | .212 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 15 | Sat Jan 1 | vs Marshall | PPD | 7-26 | .212 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 16 | Thu Jan 6 | at UTSA | W74-73 | 5-8 | .385 | - | | UTSA Convocation Center · San Antonio, TX |
| 17 | Sat Jan 8 | at UTEP | L54-87 | 5-9 | .357 | - | | Don Haskins Center · El Paso, TX |
| 18 | Thu Jan 13 | at Louisiana Tech | L57-80 | 5-10 | .333 | - | CBS | Thomas Assembly Center · Ruston, LA |
| 19 | Sun Jan 16 | vsLouisiana Tech | L62-76 | 5-11 | .313 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 20 | Wed Jan 19 | vsTBD | W100-50 | 6-11 | .353 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 21 | Sat Jan 22 | at MTSU | L60-74 | 6-12 | .333 | - | | Murphy Center · Murfreesboro, TN |
| 22 | Thu Jan 27 | vs North Texas | L54-63 | 6-13 | .316 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 23 | Sat Jan 29 | vs Rice | L62-76 | 6-14 | .300 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 24 | Thu Feb 3 | at FIU | L67-77 | 6-15 | .286 | - | | Ocean Bank Convocation Center · Miami, FL |
| 25 | Sat Feb 5 | at FAU | L57-84 | 6-16 | .273 | - | | FAU Arena · Boca Raton, FL |
| 26 | Thu Feb 10 | at UAB | L63-84 | 6-17 | .261 | - | CBS | Bartow Arena · Birmingham, AL |
| 27 | Mon Feb 14 | vsWestern KY | L77-87 | 6-18 | .250 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 28 | Thu Feb 17 | vsUTSA | L79-98 (OT) | 6-19 | .240 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 29 | Sat Feb 19 | vsUTEP | L70-84 | 6-20 | .231 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 30 | Mon Feb 21 | vsMarshall | L60-74 | 6-21 | .222 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 31 | Thu Feb 24 | atNorth Texas | L61-85 | 6-22 | .214 | - | | The Super Pit · Denton, TX |
| 32 | Sat Feb 26 | atRice | L72-77 (OT) | 6-23 | .207 | - | | Tudor Fieldhouse · Houston, TX |
| 33 | Wed Mar 2 | vsUAB | L68-81 | 6-24 | .200 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 34 | Sat Mar 5 | vs Charlotte | L67-70 | 6-25 | .194 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 35 | Tue Mar 8 | atUTSA | W67-64 | 7-25 | .219 | - | | UTSA Convocation Center · San Antonio, TX |
| 36 | Wed Mar 9 | atFAU | L59-86 | 7-26 | .212 | - | | FAU Arena · Boca Raton, FL |
