| 1 | Tue Nov 5 | vs TBD | W90-71 | 1-0 | 1.000 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 2 | Sat Nov 9 | atSouth Alabama | L69-75 | 1-1 | .500 | - | | Mitchell Center · Mobile, AL |
| 3 | Thu Nov 14 | atNorth Florida | L63-66 | 1-2 | .333 | - | | UNF Arena · Jacksonville, FL |
| 4 | Tue Nov 19 | atIowa State | L45-73 | 1-3 | .250 | - | | James H. Hilton Coliseum · Ames, IA |
| 5 | Sun Nov 24 | vsTBD | W83-64 | 2-3 | .400 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 6 | Wed Nov 27 | atGonzaga | L69-94 | 2-4 | .333 | - | ESPNU | McCarthey Athletic Center · Spokane, WA |
| 7 | Thu Nov 28 | vsSeton Hall | L56-81 | 2-5 | .286 | - | ESPN2 | Reed Green Coliseum · Hattiesburg, MS |
| 8 | Fri Nov 29 | atAlabama | L68-83 | 2-6 | .250 | - | ESPNU | Coleman Coliseum · Tuscaloosa, AL |
| 9 | Wed Dec 4 | vsTulane | L56-61 | 2-7 | .222 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 10 | Sat Dec 7 | vsS Illinois | W72-69 | 3-7 | .300 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 11 | Sat Dec 14 | vsNorth Florida | L69-72 | 3-8 | .273 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 12 | Mon Dec 16 | at#24Texas Tech | L65-71 | 3-9 | .250 | - | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 13 | Sat Dec 21 | vsTBD | W96-77 | 4-9 | .308 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 14 | Mon Dec 30 | vsLouisiana Tech | L49-80 | 4-10 | .286 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 15 | Sat Jan 4 | atLouisiana Tech | L50-78 | 4-11 | .267 | - | | Thomas Assembly Center · Ruston, LA |
| 16 | Thu Jan 9 | atUTEP | L64-76 | 4-12 | .250 | - | | Don Haskins Center · El Paso, TX |
| 17 | Sat Jan 11 | atUTSA | L70-80 | 4-13 | .235 | - | | UTSA Convocation Center · San Antonio, TX |
| 18 | Thu Jan 16 | vsNorth Texas | L52-72 | 4-14 | .222 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 19 | Sat Jan 18 | vsRice | W81-68 | 5-14 | .263 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 20 | Thu Jan 23 | atUAB | W84-77 | 6-14 | .300 | - | | Bartow Arena · Birmingham, AL |
| 21 | Sat Jan 25 | atMTSU | L63-65 | 6-15 | .286 | - | | Murphy Center · Murfreesboro, TN |
| 22 | Thu Jan 30 | vsOld Dominion | L58-68 | 6-16 | .273 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 23 | Sat Feb 1 | vsCharlotte | W74-68 (OT) | 7-16 | .304 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 24 | Thu Feb 6 | atMarshall | L58-72 | 7-17 | .292 | - | | Cam Henderson Center · Huntington, WV |
| 25 | Sat Feb 8 | atWestern KY | L72-75 | 7-18 | .280 | - | | E. A. Diddle Arena · Bowling Green, KY |
| 26 | Thu Feb 13 | vsFAU | W68-66 | 8-18 | .308 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 27 | Sat Feb 15 | vsFIU | W75-67 | 9-18 | .333 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 28 | Sat Feb 22 | vsMTSU | L53-61 | 9-19 | .321 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 29 | Sun Mar 1 | atUTEP | L56-75 | 9-20 | .310 | - | | Don Haskins Center · El Paso, TX |
| 30 | Wed Mar 4 | vsRice | L57-72 | 9-21 | .300 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 31 | Sat Mar 7 | atMTSU | L62-65 (OT) | 9-22 | .290 | - | | Murphy Center · Murfreesboro, TN |
