| 1 | Tue Nov 4 | vs Lindenwood | W98-60 | 1-0 | 1.000 | #10 | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 2 | Fri Nov 7 | vsSam Houston | W98-77 | 2-0 | 1.000 | #10 | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 3 | Tue Nov 11 | at14Illinois | L77-81 | 2-1 | .667 | #11 | FS1 | State Farm Center · Champaign, IL |
| 4 | Fri Nov 14 | vsMilwaukee | W80-63 | 3-1 | .750 | #11 | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 5 | Thu Nov 20 | vsWake Forest | W84-83 | 4-1 | .800 | #15 | CBSSN | United Supermarkets Arena · Lubbock, TX |
| 6 | Fri Nov 21 | at1Purdue | L56-86 | 4-2 | .667 | #15 | CBSSN | Mackey Arena · West Lafayette, IN |
| 7 | Wed Nov 26 | vsNew Orleans | W82-50 | 5-2 | .714 | #20 | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 8 | Sun Nov 30 | vsWyoming | W76-72 | 6-2 | .750 | #20 | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 9 | Sun Dec 7 | vsLSU | W82-58 | 7-2 | .778 | #19 | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 10 | Sat Dec 13 | at17Arkansas | L86-93 | 7-3 | .700 | #16 | ESPN2 | Bud Walton Arena · Fayetteville, AR |
| 11 | Tue Dec 16 | vsN Colorado | W101-90 | 8-3 | .727 | #19 | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 12 | Sat Dec 20 | at3Duke | W82-81 | 9-3 | .750 | #19 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 13 | Sun Dec 28 | vsWinthrop | W87-57 | 10-3 | .769 | #15 | TNT | United Supermarkets Arena · Lubbock, TX |
| 14 | Sat Jan 3 | vsOklahoma St | W102-80 | 11-3 | .786 | #15 | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 15 | Tue Jan 6 | at7Houston | L65-69 | 11-4 | .733 | #14 | FS1 | Fertitta Center · Houston, TX |
| 16 | Sat Jan 10 | atColorado | W73-71 | 12-4 | .750 | #14 | CBSSN | CU Events Center · Boulder, CO |
| 17 | Wed Jan 14 | vsUtah | W88-74 | 13-4 | .765 | #15 | Peacock | United Supermarkets Arena · Lubbock, TX |
| 18 | Sat Jan 17 | vs11BYU | W84-71 | 14-4 | .778 | #15 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 19 | Tue Jan 20 | atBaylor | W92-73 | 15-4 | .789 | #12 | Peacock | Ferrell Center · Waco, TX |
| 20 | Sat Jan 24 | vs6Houston | W90-86 | 16-4 | .800 | #12 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 21 | Sat Jan 31 | atUCF | L80-88 | 16-5 | .762 | #11 | ESPN2 | Addition Financial Arena · Orlando, FL |
| 22 | Mon Feb 2 | vs11Kansas | L61-64 | 16-6 | .727 | #13 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 23 | Sun Feb 8 | atWest Virginia | W70-63 | 17-6 | .739 | #13 | FOX | WVU Coliseum · Morgantown, WV |
| 24 | Wed Feb 11 | vsColorado | W78-44 | 18-6 | .750 | #16 | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 25 | Sat Feb 14 | at1Arizona | W78-75 (OT) | 19-6 | .760 | #16 | ESPN | McKale Center · Tucson, AZ |
| 26 | Tue Feb 17 | atArizona St | L67-72 | 19-7 | .731 | #13 | ESPN2 | Desert Financial Arena · Tempe, AZ |
| 27 | Sat Feb 21 | vsKansas St | W100-72 | 20-7 | .741 | #13 | FOX | United Supermarkets Arena · Lubbock, TX |
| 28 | Tue Feb 24 | vsCincinnati | W80-68 | 21-7 | .750 | #16 | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 29 | Sat Feb 28 | at4Iowa State | W82-73 | 22-7 | .759 | #16 | CBS | James H. Hilton Coliseum · Ames, IA |
