| 1 | Wed Nov 25 | vs N'Western St | W101-58 | 1-0 | 1.000 | #14 | | United Supermarkets Arena · Lubbock, TX |
| 2 | Fri Nov 27 | vsSam Houston | W84-52 | 2-0 | 1.000 | #14 | ESPNU | United Supermarkets Arena · Lubbock, TX |
| 3 | Sun Nov 29 | atHouston | L53-64 | 2-1 | .667 | - | ESPN2 | Fertitta Center · Houston, TX |
| 5 | Fri Dec 4 | vsTroy | W80-46 | 3-1 | .750 | #17 | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 6 | Sun Dec 6 | vsGrambling | W81-40 | 4-1 | .800 | #17 | ESPNU | United Supermarkets Arena · Lubbock, TX |
| 7 | Wed Dec 9 | vsAbilene Chrstn | W51-44 | 5-1 | .833 | #17 | | United Supermarkets Arena · Lubbock, TX |
| 8 | Sat Dec 12 | vsTexas A&M-CC | W77-57 | 6-1 | .857 | #17 | | United Supermarkets Arena · Lubbock, TX |
| 9 | Thu Dec 17 | vs5Kansas | L57-58 | 6-2 | .750 | #14 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 10 | Tue Dec 22 | atOklahoma | W69-67 | 7-2 | .778 | #15 | ESPN2 | Lloyd Noble Center · Norman, OK |
| 11 | Tue Dec 29 | vsIncarnate Word | W79-51 | 8-2 | .800 | #13 | | United Supermarkets Arena · Lubbock, TX |
| 12 | Sat Jan 2 | vsOklahoma St | L77-82 (OT) | 8-3 | .727 | #13 | | United Supermarkets Arena · Lubbock, TX |
| 13 | Tue Jan 5 | vsKansas St | W82-71 | 9-3 | .750 | #18 | ESPNU | United Supermarkets Arena · Lubbock, TX |
| 14 | Sat Jan 9 | atIowa State | W91-64 | 10-3 | .769 | #18 | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 15 | Wed Jan 13 | at4Texas | W79-77 | 11-3 | .786 | #15 | ESPN2 | Moody Center · Austin, TX |
| 16 | Sat Jan 16 | vs2Baylor | L60-68 | 11-4 | .733 | #15 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 18 | Sat Jan 23 | vsIowa State | PPD | 18-11 | .621 | #12 | | United Supermarkets Arena · Lubbock, TX |
| 19 | Mon Jan 25 | at11West Virginia | L87-88 | 11-5 | .688 | #10 | ESPN | WVU Coliseum · Morgantown, WV |
| 20 | Sat Jan 30 | atLSU | W76-71 | 12-5 | .706 | - | ESPN2 | Pete Maravich Assembly Center · Baton Rouge, LA |
| 21 | Mon Feb 1 | vs9Oklahoma | W57-52 | 13-5 | .722 | #13 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 22 | Sat Feb 6 | atKansas St | W73-62 | 14-5 | .737 | #13 | | Bramlage Coliseum · Manhattan, KS |
| 23 | Tue Feb 9 | vs14West Virginia | L71-82 | 14-6 | .700 | #7 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 24 | Sat Feb 13 | at2Baylor | PPD | 18-11 | .621 | #7 | ESPN | Ferrell Center · Waco, TX |
| 25 | Tue Feb 16 | vsTCU | PPD | 18-11 | .621 | #15 | | United Supermarkets Arena · Lubbock, TX |
| 27 | Sat Feb 20 | at23Kansas | L61-67 | 14-7 | .667 | #15 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 28 | Mon Feb 22 | atOklahoma St | L69-74 (OT) | 14-8 | .636 | #18 | ESPN | Gallagher-Iba Arena · Stillwater, OK |
| 29 | Sat Feb 27 | vs14Texas | W68-59 | 15-8 | .652 | #18 | CBS | United Supermarkets Arena · Lubbock, TX |
| 30 | Tue Mar 2 | vsTCU | W69-49 | 16-8 | .667 | #18 | | United Supermarkets Arena · Lubbock, TX |
| 31 | Thu Mar 4 | vsIowa State | W81-54 | 17-8 | .680 | #18 | | United Supermarkets Arena · Lubbock, TX |
| 32 | Sun Mar 7 | atBaylor | L73-88 | 17-9 | .654 | - | ESPN | Ferrell Center · Waco, TX |
| 33 | Thu Mar 11 | atTexas | L66-67 | 17-10 | .630 | - | ESPN2 | T-Mobile Center · Kansas City, MOS |
| 31 | Fri Mar 19 | vs11Utah State | W65-53 | 18-10 | .643 | #6 | TNT | Simon Skjodt Assembly Hall · Bloomington, IN |
| 32 | Sun Mar 21 | at3Arkansas | L66-68 | 18-11 | .621 | #6 | TNT | Hinkle Fieldhouse · Indianapolis, IN |
