| 1 | Tue Nov 4 | vs Lindenwood | 8:00 PM | 16-17 | .485 | #10 | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 2 | Fri Nov 7 | vsSam Houston | 8:00 PM | 13-19 | .406 | #10 | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 3 | Tue Nov 11 | at#17Illinois | 8:30 PM | 22-13 | .629 | #10 | FS1 | State Farm Center · Champaign, IL |
| 4 | Fri Nov 14 | vsMilwaukee | 8:00 PM | 21-11 | .656 | #10 | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 5 | Thu Nov 20 | vsWake Forest | 8:30 PM | 21-11 | .656 | #10 | CBS | United Supermarkets Arena · Lubbock, TX |
| 6 | Wed Nov 26 | vsNew Orleans | 1:00 PM | 4-27 | .129 | #10 | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 7 | Sun Nov 30 | vsWyoming | 3:00 PM | 12-20 | .375 | #10 | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 8 | Sun Dec 7 | atLSU | 3:00 PM | 14-18 | .438 | #10 | ESPN2 | Pete Maravich Assembly Center · Baton Rouge, LA |
| 9 | Sat Dec 13 | at#14Arkansas | 12:00 PM | 22-14 | .611 | #10 | ESPN2 | Bud Walton Arena · Fayetteville, AR |
| 10 | Tue Dec 16 | vsN Colorado | 8:00 PM | 25-10 | .714 | #10 | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 11 | Sat Dec 20 | at#6Duke | 8:00 PM | 35-4 | .897 | #10 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 12 | Sun Dec 28 | vsWinthrop | 2:00 PM | 23-11 | .676 | #10 | TNT | United Supermarkets Arena · Lubbock, TX |
| 13 | Sat Jan 3 | vsOklahoma St | 1:00 PM | 17-18 | .486 | #10 | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 14 | Tue Jan 6 | at#2Houston | 9:00 PM | 35-5 | .875 | #10 | FS1 | Fertitta Center · Houston, TX |
| 15 | Sat Jan 10 | atColorado | 7:00 PM | 14-21 | .400 | #10 | CBS | CU Events Center · Boulder, CO |
| 16 | Wed Jan 14 | vsUtah | 9:00 PM | 16-17 | .485 | #10 | Peacock | United Supermarkets Arena · Lubbock, TX |
| 17 | Sat Jan 17 | vs#8BYU | 8:00 PM | 26-10 | .722 | #10 | | United Supermarkets Arena · Lubbock, TX |
| 18 | Tue Jan 20 | atBaylor | 9:00 PM | 20-15 | .571 | #10 | Peacock | Ferrell Center · Waco, TX |
| 19 | Sat Jan 24 | vs#2Houston | 6:30 PM | 35-5 | .875 | #10 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 20 | Sat Jan 31 | atUCF | 12:00 PM | 20-17 | .541 | #10 | ESPN2 | Addition Financial Arena · Orlando, FL |
| 21 | Mon Feb 2 | vs#19Kansas | 9:00 PM | 21-13 | .618 | #10 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 22 | Sun Feb 8 | atWest Virginia | 1:00 PM | 19-13 | .594 | #10 | FOX | WVU Coliseum · Morgantown, WV |
| 23 | Wed Feb 11 | vsColorado | 8:00 PM | 14-21 | .400 | #10 | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 24 | Sat Feb 14 | at#13Arizona | TBD | 24-13 | .649 | #10 | | McKale Center · Tucson, AZ |
| 25 | Tue Feb 17 | atArizona St | 11:00 PM | 13-20 | .394 | #10 | | Desert Financial Arena · Tempe, AZ |
| 26 | Sat Feb 21 | vsKansas St | 2:30 PM | 16-17 | .485 | #10 | FOX | United Supermarkets Arena · Lubbock, TX |
| 27 | Tue Feb 24 | vsCincinnati | 7:00 PM | 19-16 | .543 | #10 | | United Supermarkets Arena · Lubbock, TX |
| 28 | Sat Feb 28 | at#16Iowa State | 4:00 PM | 25-10 | .714 | #10 | CBS | James H. Hilton Coliseum · Ames, IA |
| 29 | Tue Mar 3 | vsTCU | 7:00 PM | 16-16 | .500 | #10 | FS1 | United Supermarkets Arena · Lubbock, TX |
| 30 | Sat Mar 7 | at#8BYU | 10:30 PM | 26-10 | .722 | #10 | ESPN | Marriott Center · Provo, UT |
