| 1 | Wed Nov 8 | vs E Texas A&M | W73-46 | 1-0 | 1.000 | - | | United Supermarkets Arena · Lubbock, TX |
| 2 | Sun Nov 12 | vs San Jose St | W56-42 | 2-0 | 1.000 | - | | United Supermarkets Arena · Lubbock, TX |
| 3 | Thu Nov 16 | vs Texas A&M-CC | W73-64 | 3-0 | 1.000 | - | | United Supermarkets Arena · Lubbock, TX |
| 4 | Wed Nov 22 | at Villanova | L69-85 | 3-1 | .750 | - | ESPN2 | Finneran Pavilion · Villanova, PA |
| 5 | Thu Nov 23 | at Northern Iowa | W72-70 | 4-1 | .800 | - | ESPN2 | McLeod Center · Cedar Falls, IA |
| 6 | Fri Nov 24 | vs Michigan | W73-57 | 5-1 | .833 | - | ESPNU | United Supermarkets Arena · Lubbock, TX |
| 7 | Thu Nov 30 | at Butler | L95-103 (OT) | 5-2 | .714 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 8 | Wed Dec 6 | vs Omaha | W87-58 | 6-2 | .750 | - | | United Supermarkets Arena · Lubbock, TX |
| 9 | Tue Dec 12 | vs Oral Roberts | W82-76 | 7-2 | .778 | - | | United Supermarkets Arena · Lubbock, TX |
| 10 | Sat Dec 16 | vs Vanderbilt | W76-54 | 8-2 | .800 | - | | United Supermarkets Arena · Lubbock, TX |
| 11 | Thu Dec 21 | vs UT Arlington | W77-66 | 9-2 | .818 | - | | United Supermarkets Arena · Lubbock, TX |
| 12 | Thu Dec 28 | vs Sam Houston | W96-60 | 10-2 | .833 | - | | United Supermarkets Arena · Lubbock, TX |
| 13 | Mon Jan 1 | vs North Alabama | W85-57 | 11-2 | .846 | - | | United Supermarkets Arena · Lubbock, TX |
| 14 | Sat Jan 6 | at #20Texas | W78-67 | 12-2 | .857 | - | ESPN2 | Moody Center · Austin, TX |
| 15 | Tue Jan 9 | vs Oklahoma St | W90-73 | 13-2 | .867 | - | | United Supermarkets Arena · Lubbock, TX |
| 16 | Sat Jan 13 | vs Kansas St | W60-59 | 14-2 | .875 | - | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 17 | Wed Jan 17 | at #5Houston | L54-77 | 14-3 | .824 | #25 | ESPNU | Fertitta Center · Houston, TX |
| 18 | Sat Jan 20 | vs #20BYU | W85-78 | 15-3 | .833 | #25 | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 19 | Sat Jan 27 | at #11Oklahoma | W85-84 | 16-3 | .842 | #20 | | Lloyd Noble Center · Norman, OK |
| 20 | Tue Jan 30 | at #25TCU | L78-85 | 16-4 | .800 | #15 | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 21 | Sat Feb 3 | vs Cincinnati | L72-75 | 16-5 | .762 | #15 | | United Supermarkets Arena · Lubbock, TX |
| 22 | Tue Feb 6 | at #13Baylor | L73-79 | 16-6 | .727 | #23 | ESPN | Ferrell Center · Waco, TX |
| 23 | Sat Feb 10 | vs UCF | W66-59 | 17-6 | .739 | #23 | | United Supermarkets Arena · Lubbock, TX |
| 24 | Mon Feb 12 | vs #6Kansas | W79-50 | 18-6 | .750 | - | ESPN | United Supermarkets Arena · Lubbock, TX |
| 25 | Sat Feb 17 | at #10Iowa State | L74-82 | 18-7 | .720 | - | | James H. Hilton Coliseum · Ames, IA |
| 26 | Tue Feb 20 | vsTCU | W82-81 | 19-7 | .731 | #23 | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 27 | Sat Feb 24 | atUCF | L61-75 | 19-8 | .704 | #23 | | Addition Financial Arena · Orlando, FL |
| 28 | Tue Feb 27 | vsTexas | L69-81 | 19-9 | .679 | - | ESPN | United Supermarkets Arena · Lubbock, TX |
| 29 | Sat Mar 2 | at West Virginia | W81-70 | 20-9 | .690 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 30 | Tue Mar 5 | atOklahoma St | W75-58 | 21-9 | .700 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 31 | Sat Mar 9 | vs#11Baylor | W78-68 | 22-9 | .710 | - | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 32 | Thu Mar 14 | vs#20BYU | W81-67 | 23-9 | .719 | #25 | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 33 | Fri Mar 15 | at#1Houston | L59-82 | 23-10 | .697 | #25 | ESPN2 | Fertitta Center · Houston, TX |
| 34 | Thu Mar 21 | vs #11NC State | L67-80 | 23-11 | .676 | #6 | CBS | United Supermarkets Arena · Lubbock, TX |
