| 1 | Tue Nov 5 | vs E Illinois | W85-60 | 1-0 | 1.000 | #13 | | United Supermarkets Arena · Lubbock, TX |
| 2 | Sat Nov 9 | vsBethune | W79-44 | 2-0 | 1.000 | #13 | | United Supermarkets Arena · Lubbock, TX |
| 3 | Wed Nov 13 | vsHou Christian | W103-74 | 3-0 | 1.000 | #11 | | United Supermarkets Arena · Lubbock, TX |
| 4 | Thu Nov 21 | vsTennessee St | W72-57 | 4-0 | 1.000 | - | | United Supermarkets Arena · Lubbock, TX |
| 5 | Sun Nov 24 | vsLong Island | W96-66 | 5-0 | 1.000 | - | | United Supermarkets Arena · Lubbock, TX |
| 6 | Thu Nov 28 | vsIowa | L61-72 | 5-1 | .833 | - | FS1 | Orleans Arena · Las Vegas, NV |
| 7 | Fri Nov 29 | vsCreighton | L76-83 (OT) | 5-2 | .714 | - | FS1 | Orleans Arena · Las Vegas, NV |
| 8 | Wed Dec 4 | atDePaul | L60-65 (OT) | 5-3 | .625 | - | FS1 | Wintrust Arena · Chicago, IL |
| 9 | Tue Dec 10 | atLouisville | W70-57 | 6-3 | .667 | - | ESPN | KFC Yum! Center · Louisville, KY |
| 10 | Mon Dec 16 | vsSouthern Miss | W71-65 | 7-3 | .700 | #24 | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 11 | Sat Dec 21 | vsUT Rio Grande | W68-58 | 8-3 | .727 | #24 | | United Supermarkets Arena · Lubbock, TX |
| 12 | Sun Dec 29 | vsBakersfield | W73-58 | 9-3 | .750 | #23 | | United Supermarkets Arena · Lubbock, TX |
| 13 | Sat Jan 4 | vsOklahoma St | W85-50 | 10-3 | .769 | #22 | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 14 | Tue Jan 7 | vs#4Baylor | L52-57 | 10-4 | .714 | #22 | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 15 | Sat Jan 11 | at#17West Virginia | L54-66 | 10-5 | .667 | #22 | ESPN | WVU Coliseum · Morgantown, WV |
| 16 | Tue Jan 14 | atKansas St | W77-63 | 11-5 | .688 | #23 | | Bramlage Coliseum · Manhattan, KS |
| 17 | Sat Jan 18 | vsIowa State | W72-52 | 12-5 | .706 | #23 | ESPNU | United Supermarkets Arena · Lubbock, TX |
| 18 | Tue Jan 21 | atTCU | L54-65 | 12-6 | .667 | #18 | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 19 | Sat Jan 25 | vsKentucky | L74-76 (OT) | 12-7 | .632 | - | ESPN | United Supermarkets Arena · Lubbock, TX |
| 20 | Wed Jan 29 | vs#12West Virginia | W89-81 | 13-7 | .650 | - | | United Supermarkets Arena · Lubbock, TX |
| 21 | Sat Feb 1 | at#3Kansas | L75-78 | 13-8 | .619 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 22 | Tue Feb 4 | vsOklahoma | W69-61 | 14-8 | .636 | - | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 23 | Sat Feb 8 | atTexas | W62-57 | 15-8 | .652 | - | ESPN2 | Moody Center · Austin, TX |
| 24 | Mon Feb 10 | vsTCU | W88-42 | 16-8 | .667 | #24 | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 25 | Sat Feb 15 | atOklahoma St | L70-73 | 16-9 | .640 | #24 | CBS | Gallagher-Iba Arena · Stillwater, OK |
| 26 | Wed Feb 19 | vsKansas St | W69-62 | 17-9 | .654 | - | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 27 | Sat Feb 22 | atIowa State | W87-57 | 18-9 | .667 | - | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 28 | Tue Feb 25 | atOklahoma | L51-65 | 18-10 | .643 | #22 | ESPN2 | Lloyd Noble Center · Norman, OK |
| 29 | Sat Feb 29 | vsTexas | L58-68 | 18-11 | .621 | #22 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 30 | Mon Mar 2 | at#4Baylor | L68-71 (OT) | 18-12 | .600 | - | ESPN | Ferrell Center · Waco, TX |
| 31 | Sat Mar 7 | vs#1Kansas | L62-66 | 18-13 | .581 | - | ESPN | United Supermarkets Arena · Lubbock, TX |
