| 1 | Tue Nov 5 | vs Bethune | W94-61 | 1-0 | 1.000 | - | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 2 | Fri Nov 8 | vsN'Western St | W86-65 | 2-0 | 1.000 | - | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 3 | Wed Nov 13 | vsWyoming | W96-49 | 3-0 | 1.000 | - | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 4 | Mon Nov 18 | vsAR-Pine Bluff | W98-64 | 4-0 | 1.000 | - | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 5 | Thu Nov 21 | atSaint Joseph's | L77-78 | 4-1 | .800 | - | ESPN2 | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 6 | Fri Nov 22 | vsSyracuse | W79-74 | 5-1 | .833 | - | ESPNU | United Supermarkets Arena · Lubbock, TX |
| 7 | Fri Nov 29 | vsN Colorado | W89-64 | 6-1 | .857 | - | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 8 | Wed Dec 4 | vsDePaul | W76-62 | 7-1 | .875 | - | ESPNU | United Supermarkets Arena · Lubbock, TX |
| 9 | Sun Dec 8 | vs#22Texas A&M | L67-72 | 7-2 | .778 | - | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 10 | Mon Dec 16 | vsOral Roberts | W86-50 | 8-2 | .800 | - | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 11 | Sat Dec 21 | vsLamar | W101-57 | 9-2 | .818 | - | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 12 | Tue Dec 31 | vsUCF | L83-87 | 9-3 | .750 | - | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 13 | Sat Jan 4 | atUtah | W93-65 | 10-3 | .769 | - | ESPN+ | Jon M. Huntsman Center · Salt Lake City, UT |
| 14 | Tue Jan 7 | atBYU | W72-67 | 11-3 | .786 | - | ESPN+ | Marriott Center · Provo, UT |
| 15 | Sat Jan 11 | vs#3Iowa State | L84-85 (OT) | 11-4 | .733 | - | ESPN | United Supermarkets Arena · Lubbock, TX |
| 16 | Tue Jan 14 | atKansas St | W61-57 | 12-4 | .750 | - | CBS | Bramlage Coliseum · Manhattan, KS |
| 17 | Sat Jan 18 | vsArizona | W70-54 | 13-4 | .765 | - | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 18 | Tue Jan 21 | atCincinnati | W81-71 | 14-4 | .778 | - | ESPNU | Fifth Third Arena · Cincinnati, OH |
| 19 | Sun Jan 26 | vsOklahoma St | W64-54 | 15-4 | .789 | - | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 20 | Wed Jan 29 | vsTCU | W71-57 | 16-4 | .800 | #22 | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 21 | Sat Feb 1 | at#6Houston | W82-81 (OT) | 17-4 | .810 | #22 | ESPN2 | Fertitta Center · Houston, TX |
| 22 | Tue Feb 4 | vsBaylor | W73-59 | 18-4 | .818 | #13 | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 23 | Sat Feb 8 | at#20Arizona | L73-82 | 18-5 | .783 | #13 | ESPNEWS | McKale Center · Tucson, AZ |
| 24 | Wed Feb 12 | vsArizona St | W111-106 (2OT) | 19-5 | .792 | #12 | CBS | United Supermarkets Arena · Lubbock, TX |
| 25 | Sat Feb 15 | atOklahoma St | W93-55 | 20-5 | .800 | #12 | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 26 | Tue Feb 18 | atTCU | L66-69 | 20-6 | .769 | #9 | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 27 | Sat Feb 22 | vsWest Virginia | W73-51 | 21-6 | .778 | #9 | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 28 | Mon Feb 24 | vs#4Houston | L61-69 | 21-7 | .750 | #10 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 29 | Sat Mar 1 | atKansas | W78-73 | 22-7 | .759 | #10 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 30 | Wed Mar 5 | vsColorado | W91-75 | 23-7 | .767 | #9 | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 31 | Sat Mar 8 | atArizona St | W85-57 | 24-7 | .774 | #9 | ESPNU | Desert Financial Arena · Tempe, AZ |
| 32 | Thu Mar 13 | vsBaylor | W76-74 | 25-7 | .781 | #9 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 33 | Fri Mar 14 | vsArizona | L80-86 | 25-8 | .758 | #9 | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 34 | Thu Mar 20 | vs#14UNC Wilmington | W82-72 | 26-8 | .765 | #3 | truTV | United Supermarkets Arena · Lubbock, TX |
| 35 | Sat Mar 22 | vs#11Drake | W77-64 | 27-8 | .771 | #3 | TNT | United Supermarkets Arena · Lubbock, TX |
| 36 | Thu Mar 27 | vs#10Arkansas | W85-83 (OT) | 28-8 | .778 | #3 | TBS | Chase Center · San Francisco, CA |
| 37 | Sat Mar 29 | at#1Florida | L79-84 | 28-9 | .757 | #3 | TBS | Chase Center · San Francisco, CA |
