| 1 | Mon Nov 4 | at CA Baptist | L78-83 | 0-1 | .000 | - | ESPN+ | CBU Events Center · Riverside, CA |
| 2 | Fri Nov 8 | vs TBD | W97-53 | 1-1 | .500 | - | ESPN+ | Alice P. McDermott Convocation Center · San Antonio, TX |
| 3 | Tue Nov 12 | vs Prairie View | W84-81 | 2-1 | .667 | - | ESPN+ | Alice P. McDermott Convocation Center · San Antonio, TX |
| 4 | Sat Nov 16 | vs AR-Pine Bluff | W92-64 | 3-1 | .750 | - | ESPN+ | Alice P. McDermott Convocation Center · San Antonio, TX |
| 5 | Fri Nov 22 | at N Arizona | L74-75 | 3-2 | .600 | - | ESPN+ | J. Lawrence Walkup Skydome · Flagstaff, AZ |
| 6 | Mon Nov 25 | at South Alabama | L63-84 | 3-3 | .500 | - | ESPN+ | Mitchell Center · Mobile, AL |
| 7 | Wed Nov 27 | at W Illinois | W86-75 | 4-3 | .571 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 8 | Thu Dec 5 | vs N'Western St | L70-72 | 4-4 | .500 | - | ESPN+ | Alice P. McDermott Convocation Center · San Antonio, TX |
| 9 | Sat Dec 7 | vs E Texas A&M | W65-53 | 5-4 | .556 | - | ESPN+ | Alice P. McDermott Convocation Center · San Antonio, TX |
| 10 | Tue Dec 10 | at #4Duke | L46-72 | 5-5 | .500 | - | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 11 | Sun Dec 15 | vsTBD | W93-69 | 6-5 | .545 | - | ESPN+ | Alice P. McDermott Convocation Center · San Antonio, TX |
| 12 | Thu Dec 19 | vsTBD | W101-57 | 7-5 | .583 | - | ESPN+ | Alice P. McDermott Convocation Center · San Antonio, TX |
| 13 | Sun Dec 29 | vsTBD | W99-48 | 8-5 | .615 | - | ESPN+ | Alice P. McDermott Convocation Center · San Antonio, TX |
| 14 | Sat Jan 4 | at SF Austin | W55-49 | 9-5 | .643 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 15 | Mon Jan 6 | at Lamar | L58-72 | 9-6 | .600 | - | ESPN+ | Montagne Center · Beaumont, TX |
| 16 | Sat Jan 11 | at Hou Christian | L76-81 | 9-7 | .563 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 17 | Mon Jan 13 | vs Nicholls | L82-88 | 9-8 | .529 | - | ESPN+ | Alice P. McDermott Convocation Center · San Antonio, TX |
| 18 | Sat Jan 18 | vs Texas A&M-CC | L63-69 | 9-9 | .500 | - | ESPN+ | Alice P. McDermott Convocation Center · San Antonio, TX |
| 19 | Mon Jan 20 | vs UT Rio Grande | L78-85 | 9-10 | .474 | - | ESPN+ | Alice P. McDermott Convocation Center · San Antonio, TX |
| 20 | Sat Jan 25 | at SE Louisiana | L63-86 | 9-11 | .450 | - | ESPN+ | University Center (LA) · Hammond, LA |
| 21 | Mon Jan 27 | at New Orleans | W74-58 | 10-11 | .476 | - | ESPN+ | Lakefront Arena · New Orleans, LA |
| 22 | Sat Feb 1 | vsHou Christian | W74-64 | 11-11 | .500 | - | ESPN+ | Alice P. McDermott Convocation Center · San Antonio, TX |
| 23 | Mon Feb 3 | at McNeese | L65-67 | 11-12 | .478 | - | ESPN+ | Legacy Center · Lake Charles, LA |
| 24 | Sat Feb 8 | vsSE Louisiana | L66-71 | 11-13 | .458 | - | ESPN+ | Alice P. McDermott Convocation Center · San Antonio, TX |
| 25 | Mon Feb 10 | vsNew Orleans | W75-65 | 12-13 | .480 | - | ESPN+ | Alice P. McDermott Convocation Center · San Antonio, TX |
| 26 | Sat Feb 15 | atTexas A&M-CC | L55-69 | 12-14 | .462 | - | ESPN+ | American Bank Center · Corpus Christi, TX |
| 27 | Mon Feb 17 | atUT Rio Grande | W66-60 | 13-14 | .481 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
