| 1 | Mon Nov 4 | vs TBD | W85-51 | 1-0 | 1.000 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 2 | Sun Nov 10 | at Drake | L51-66 | 1-1 | .500 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 3 | Tue Nov 12 | vsTBD | W87-68 | 2-1 | .667 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 4 | Sat Nov 16 | at Arkansas St | L49-59 | 2-2 | .500 | - | ESPN+ | First National Bank Arena · Jonesboro, AR |
| 5 | Thu Nov 21 | vs Presbyterian | L55-58 (OT) | 2-3 | .400 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 6 | Fri Nov 22 | vs Monmouth | W72-67 | 3-3 | .500 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 7 | Sat Nov 23 | vs Youngstown St | W64-57 | 4-3 | .571 | - | | William R. Johnson Coliseum · Nacogdoches, TX |
| 8 | Fri Nov 29 | at UL Monroe | W68-60 | 5-3 | .625 | - | ESPN+ | Fant-Ewing Coliseum · Monroe, LA |
| 9 | Thu Dec 5 | at UT Rio Grande | L65-68 | 5-4 | .556 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 10 | Sat Dec 7 | at Texas A&M-CC | L48-67 | 5-5 | .500 | - | ESPN+ | American Bank Center · Corpus Christi, TX |
| 11 | Sun Dec 15 | at #12Oregon | L61-79 | 5-6 | .455 | - | BTN | Matthew Knight Arena · Eugene, OR |
| 12 | Fri Dec 20 | vsTBD | W82-56 | 6-6 | .500 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 13 | Tue Dec 31 | at Abilene Chrstn | W62-57 | 7-6 | .538 | - | ESPN+ | Moody Coliseum (Abilene) · Abilene, TX |
| 14 | Sat Jan 4 | vs Incarnate Word | L49-55 | 7-7 | .500 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 15 | Mon Jan 6 | vs Hou Christian | L73-83 | 7-8 | .467 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 16 | Sat Jan 11 | at Lamar | W72-63 | 8-8 | .500 | - | ESPN+ | Montagne Center · Beaumont, TX |
| 17 | Mon Jan 13 | vs SE Louisiana | L59-66 | 8-9 | .471 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 18 | Sat Jan 18 | at Nicholls | L61-73 | 8-10 | .444 | - | ESPN+ | David R. Stopher Gymnasium · Thibodaux, LA |
| 19 | Mon Jan 20 | at McNeese | L59-79 | 8-11 | .421 | - | ESPN+ | Legacy Center · Lake Charles, LA |
| 20 | Sat Jan 25 | vs N'Western St | L54-57 (OT) | 8-12 | .400 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 21 | Mon Jan 27 | vs E Texas A&M | W79-72 | 9-12 | .429 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 22 | Sat Feb 1 | vsLamar | L62-67 | 9-13 | .409 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 23 | Mon Feb 3 | at New Orleans | W88-85 (OT) | 10-13 | .435 | - | ESPN+ | Lakefront Arena · New Orleans, LA |
| 24 | Sat Feb 8 | vsTexas A&M-CC | W78-64 | 11-13 | .458 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 25 | Mon Feb 10 | vsUT Rio Grande | W85-75 | 12-13 | .480 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 26 | Sat Feb 15 | atN'Western St | W70-68 | 13-13 | .500 | - | ESPN+ | Prather Coliseum · Natchitoches, LA |
| 27 | Mon Feb 17 | atE Texas A&M | W76-74 | 14-13 | .519 | - | ESPN+ | The Field House · Commerce, TX |
| 28 | Sat Feb 22 | atIncarnate Word | L61-63 | 14-14 | .500 | - | ESPN+ | Alice P. McDermott Convocation Center · San Antonio, TX |
| 29 | Mon Feb 24 | atHou Christian | L56-72 | 14-15 | .483 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 30 | Sat Mar 1 | vsNicholls | L70-94 | 14-16 | .467 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 31 | Mon Mar 3 | vsMcNeese | L64-95 | 14-17 | .452 | - | ESPNU | William R. Johnson Coliseum · Nacogdoches, TX |
