| 1 | Mon Nov 4 | vs Charleston So | W91-64 | 1-0 | 1.000 | - | ESPN+ | Littlejohn Coliseum · Clemson, SC |
| 2 | Fri Nov 8 | vs St Francis PA | W88-62 | 2-0 | 1.000 | - | ESPN+ | Littlejohn Coliseum · Clemson, SC |
| 3 | Tue Nov 12 | vs E Kentucky | W75-62 | 3-0 | 1.000 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 4 | Sun Nov 17 | at Boise St | L71-84 | 3-1 | .750 | - | CBS | ExtraMile Arena · Boise, ID |
| 5 | Thu Nov 21 | vs Radford | W79-51 | 4-1 | .800 | - | ESPN+ | Littlejohn Coliseum · Clemson, SC |
| 6 | Mon Nov 25 | at San Francisco | W70-55 | 5-1 | .833 | - | CBS | War Memorial at the Sobrato Center · San Francisco, CA |
| 7 | Tue Nov 26 | at Penn State | W75-67 | 6-1 | .857 | - | CBS | Bryce Jordan Center · University Park, PA |
| 8 | Fri Nov 29 | vs FAMU | W86-58 | 7-1 | .875 | - | ESPN+ | Littlejohn Coliseum · Clemson, SC |
| 9 | Tue Dec 3 | vs #4Kentucky | W70-66 | 8-1 | .889 | - | ESPN | Littlejohn Coliseum · Clemson, SC |
| 10 | Sat Dec 7 | at Miami | W65-55 | 9-1 | .900 | - | ESPN2 | Watsco Center · Coral Gables, FL |
| 11 | Sat Dec 14 | vs Memphis | L82-87 (OT) | 9-2 | .818 | #16 | ESPN2 | Littlejohn Coliseum · Clemson, SC |
| 12 | Tue Dec 17 | at South Carolina | L88-91 (OT) | 9-3 | .750 | #25 | SEC Network | Colonial Life Arena · Columbia, SC |
| 13 | Sat Dec 21 | vs Wake Forest | W73-62 | 10-3 | .769 | #25 | ESPN | Littlejohn Coliseum · Clemson, SC |
| 14 | Wed Jan 1 | vs Stanford | W85-71 | 11-3 | .786 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 15 | Sat Jan 4 | vs California | W80-68 | 12-3 | .800 | - | ESPN2 | Littlejohn Coliseum · Clemson, SC |
| 16 | Tue Jan 7 | at Louisville | L64-74 | 12-4 | .750 | - | ESPNU | KFC Yum! Center · Louisville, KY |
| 17 | Sat Jan 11 | vs Florida St | W77-57 | 13-4 | .765 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 18 | Tue Jan 14 | at Georgia Tech | W70-59 | 14-4 | .778 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 19 | Sat Jan 18 | at Pitt | W78-75 (OT) | 15-4 | .789 | - | The CW Network | Petersen Events Center · Pittsburgh, PA |
| 20 | Wed Jan 22 | vs Syracuse | W86-72 | 16-4 | .800 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 21 | Sat Jan 25 | at Virginia Tech | W72-57 | 17-4 | .810 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 22 | Sat Feb 1 | at NC State | W68-58 | 18-4 | .818 | - | The CW Network | PNC Arena · Raleigh, NC |
| 23 | Tue Feb 4 | vsGeorgia Tech | L86-89 (3OT) | 18-5 | .783 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 24 | Sat Feb 8 | vs #2Duke | W77-71 | 19-5 | .792 | - | ESPN | Littlejohn Coliseum · Clemson, SC |
| 25 | Mon Feb 10 | vs UNC | W85-65 | 20-5 | .800 | #23 | ESPN | Littlejohn Coliseum · Clemson, SC |
| 26 | Sat Feb 15 | atFlorida St | W72-46 | 21-5 | .808 | #23 | The CW Network | Donald L. Tucker Center · Tallahassee, FL |
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