| 1 | Mon Nov 3 | vs New Hampshire | W88-38 | 1-0 | 1.000 | - | ACC Extra | Littlejohn Coliseum · Clemson, SC |
| 2 | Fri Nov 7 | vsGardner-Webb | W97-59 | 2-0 | 1.000 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 3 | Tue Nov 11 | vsMorehead St | W83-56 | 3-0 | 1.000 | - | ACC Extra | Littlejohn Coliseum · Clemson, SC |
| 4 | Sat Nov 15 | atGeorgetown | L74-79 | 3-1 | .750 | - | Peacock | Capital One Arena · Washington, D.C. |
| 5 | Mon Nov 17 | vsNorth Alabama | W81-61 | 4-1 | .800 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 6 | Fri Nov 21 | vsWest Virginia | W70-67 | 5-1 | .833 | - | ESPNU | TD Arena · Charleston, SC |
| 7 | Sun Nov 23 | atGeorgia | W97-94 (OT) | 6-1 | .857 | - | ESPN | TD Arena · Charleston, SC |
| 8 | Fri Nov 28 | vsAlabama A&M | W92-56 | 7-1 | .875 | - | ACC Extra | Littlejohn Coliseum · Clemson, SC |
| 9 | Wed Dec 3 | at12Alabama | L84-90 | 7-2 | .778 | - | ESPNU | Coleman Coliseum · Tuscaloosa, AL |
| 10 | Tue Dec 9 | at10BYU | L64-67 | 7-3 | .700 | - | ESPN | Marriott Center · Provo, UT |
| 11 | Sat Dec 13 | vsMercer | W70-63 | 8-3 | .727 | - | ACC Extra | Littlejohn Coliseum · Clemson, SC |
| 12 | Tue Dec 16 | vsSouth Carolina | W68-61 | 9-3 | .750 | - | ESPN2 | Littlejohn Coliseum · Clemson, SC |
| 13 | Sun Dec 21 | vsCincinnati | W68-65 | 10-3 | .769 | - | ESPN | Littlejohn Coliseum · Clemson, SC |
| 14 | Wed Dec 31 | atSyracuse | W64-61 | 11-3 | .786 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 15 | Sat Jan 3 | atPitt | W73-68 | 12-3 | .800 | - | The CW Network | Petersen Events Center · Pittsburgh, PA |
| 16 | Wed Jan 7 | vs24SMU | W74-70 | 13-3 | .813 | - | ESPNU | Littlejohn Coliseum · Clemson, SC |
| 17 | Sat Jan 10 | atNotre Dame | W76-61 | 14-3 | .824 | - | ESPN2 | Purcell Pavilion · South Bend, IN |
| 18 | Tue Jan 13 | vsBoston College | W74-50 | 15-3 | .833 | #22 | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 19 | Sat Jan 17 | vsMiami | W69-59 | 16-3 | .842 | #22 | The CW Network | Littlejohn Coliseum · Clemson, SC |
| 20 | Tue Jan 20 | vsNC State | L76-80 (OT) | 16-4 | .800 | #18 | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 21 | Sat Jan 24 | atGeorgia Tech | W77-63 | 17-4 | .810 | #18 | ACC Network | McCamish Pavilion · Atlanta, GA |
| 22 | Sat Jan 31 | vsPitt | W63-52 | 18-4 | .818 | #22 | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 23 | Wed Feb 4 | atStanford | W66-64 | 19-4 | .826 | #20 | ACC Network | Maples Pavilion · Stanford, CA |
| 24 | Sat Feb 7 | atCalifornia | W77-55 | 20-4 | .833 | #20 | ACC Network | Haas Pavilion · Berkeley, CA |
| 25 | Wed Feb 11 | vsVirginia Tech | L66-76 | 20-5 | .800 | #20 | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 26 | Sat Feb 14 | at4Duke | L54-67 | 20-6 | .769 | #20 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 27 | Wed Feb 18 | atWake Forest | L77-85 | 20-7 | .741 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 28 | Sat Feb 21 | vsFlorida St | L65-70 | 20-8 | .714 | - | The CW Network | Littlejohn Coliseum · Clemson, SC |
| 29 | Sat Feb 28 | vs24Louisville | W80-75 | 21-8 | .724 | - | ESPN2 | Littlejohn Coliseum · Clemson, SC |
