| 1 | Mon Nov 3 | vs New Hampshire | 7:00 PM | 8-24 | .250 | - | | Littlejohn Coliseum · Clemson, SC |
| 2 | Fri Nov 7 | vsGardner-Webb | 7:00 PM | 11-20 | .355 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 3 | Tue Nov 11 | vsMorehead St | TBD | 15-17 | .469 | - | | Littlejohn Coliseum · Clemson, SC |
| 4 | Sat Nov 15 | atGeorgetown | TBD | 18-16 | .529 | - | | Capital One Arena · Washington, D.C. |
| 5 | Mon Nov 17 | vsNorth Alabama | 9:00 PM | 24-11 | .686 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 6 | Fri Nov 21 | vsWest Virginia | 6:30 PM | 19-13 | .594 | - | | Littlejohn Coliseum · Clemson, SC |
| 7 | Fri Nov 28 | vsAlabama A&M | TBD | 10-22 | .313 | - | | Littlejohn Coliseum · Clemson, SC |
| 8 | Wed Dec 3 | at#15Alabama | 7:00 PM | 28-9 | .757 | - | ESPNU | Coleman Coliseum · Tuscaloosa, AL |
| 9 | Tue Dec 9 | at#8BYU | 6:30 PM | 26-10 | .722 | - | ESPN | Marriott Center · Provo, UT |
| 10 | Sat Dec 13 | vsMercer | TBD | 14-19 | .424 | - | | Littlejohn Coliseum · Clemson, SC |
| 11 | Tue Dec 16 | vsSouth Carolina | 7:00 PM | 12-20 | .375 | - | ESPN2 | Littlejohn Coliseum · Clemson, SC |
| 12 | Sun Dec 21 | atCincinnati | 3:00 PM | 19-16 | .543 | - | ESPN | Fifth Third Arena · Cincinnati, OH |
| 13 | Wed Dec 31 | atSyracuse | 2:00 PM | 14-19 | .424 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 14 | Sat Jan 3 | atPitt | TBD | 17-15 | .531 | - | | Petersen Events Center · Pittsburgh, PA |
| 15 | Tue Jan 6 | vsSMU | TBD | 24-11 | .686 | - | | Littlejohn Coliseum · Clemson, SC |
| 16 | Sat Jan 10 | atNotre Dame | 6:00 PM | 15-18 | .455 | - | ESPN2 | Purcell Pavilion · South Bend, IN |
| 17 | Tue Jan 13 | vsBoston College | 7:00 PM | 12-19 | .387 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 18 | Sat Jan 17 | vsMiami | 2:15 PM | 7-24 | .226 | - | The CW Network | Littlejohn Coliseum · Clemson, SC |
| 19 | Tue Jan 20 | vsNC State | 7:00 PM | 12-19 | .387 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 20 | Sat Jan 24 | atGeorgia Tech | 12:00 PM | 17-17 | .500 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 21 | Sat Jan 31 | vsPitt | 12:00 PM | 17-15 | .531 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 22 | Wed Feb 4 | atStanford | 10:00 PM | 21-14 | .600 | - | ACC Network | Maples Pavilion · Stanford, CA |
| 23 | Sat Feb 7 | atCalifornia | 8:00 PM | 14-19 | .424 | - | ACC Network | Haas Pavilion · Berkeley, CA |
| 24 | Wed Feb 11 | vsVirginia Tech | 7:00 PM | 13-19 | .406 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 25 | Sat Feb 14 | at#6Duke | 12:00 PM | 35-4 | .897 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 26 | Wed Feb 18 | atWake Forest | 7:00 PM | 21-11 | .656 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 27 | Sat Feb 21 | vsFlorida St | TBD | 17-15 | .531 | - | | Littlejohn Coliseum · Clemson, SC |
| 28 | Sat Feb 28 | vs#11Louisville | TBD | 27-8 | .771 | - | | Littlejohn Coliseum · Clemson, SC |
| 29 | Tue Mar 3 | at#25UNC | TBD | 23-14 | .622 | - | | Dean E. Smith Center · Chapel Hill, NC |
| 30 | Sat Mar 7 | vsGeorgia Tech | 12:00 PM | 17-17 | .500 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
