| 1 | Wed Nov 25 | vs Mississippi St | W53-42 | 1-0 | 1.000 | - | CBS | Littlejohn Coliseum · Clemson, SC |
| 2 | Thu Nov 26 | vs Purdue | W81-70 | 2-0 | 1.000 | - | CBS | Littlejohn Coliseum · Clemson, SC |
| 3 | Wed Dec 2 | vs SC State | W75-38 | 3-0 | 1.000 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 4 | Wed Dec 9 | vs Maryland | W67-51 | 4-0 | 1.000 | - | ESPN2 | Littlejohn Coliseum · Clemson, SC |
| 5 | Sat Dec 12 | at Alabama | W64-56 | 5-0 | 1.000 | - | | Coleman Coliseum · Tuscaloosa, AL |
| 6 | Tue Dec 15 | at Virginia Tech | L60-66 | 5-1 | .833 | #24 | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 8 | Mon Dec 21 | vs Morehead St | W66-51 | 6-1 | .857 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 9 | Tue Dec 29 | vs #18Florida St | W77-67 | 7-1 | .875 | - | | Littlejohn Coliseum · Clemson, SC |
| 10 | Sat Jan 2 | at Miami | W66-65 | 8-1 | .889 | - | | Watsco Center · Coral Gables, FL |
| 11 | Tue Jan 5 | vs NC State | W74-70 (OT) | 9-1 | .900 | #19 | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 13 | Sat Jan 16 | vs #18Virginia | L50-85 | 9-2 | .818 | #12 | ESPN | Littlejohn Coliseum · Clemson, SC |
| 14 | Wed Jan 20 | at Georgia Tech | L65-83 | 9-3 | .750 | #20 | | McCamish Pavilion · Atlanta, GA |
| 15 | Sat Jan 23 | atFlorida St | L61-80 | 9-4 | .692 | #20 | ABC | Donald L. Tucker Center · Tallahassee, FL |
| 16 | Wed Jan 27 | vs Boston College | PPD | 16-8 | .667 | - | | Littlejohn Coliseum · Clemson, SC |
| 17 | Wed Jan 27 | vs #25Louisville | W54-50 | 10-4 | .714 | - | | Littlejohn Coliseum · Clemson, SC |
| 18 | Sat Jan 30 | at Duke | L53-79 | 10-5 | .667 | - | ESPN2 | Cameron Indoor Stadium · Durham, NC |
| 19 | Tue Feb 2 | vs UNC | W63-50 | 11-5 | .688 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 20 | Sat Feb 6 | vs Syracuse | W78-61 | 12-5 | .706 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 21 | Fri Feb 12 | vsGeorgia Tech | W74-72 | 13-5 | .722 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 24 | Wed Feb 24 | at Wake Forest | W60-39 | 14-5 | .737 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 25 | Sat Feb 27 | vsMiami | W66-58 | 15-5 | .750 | - | | Littlejohn Coliseum · Clemson, SC |
| 26 | Wed Mar 3 | atSyracuse | L54-64 | 15-6 | .714 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 27 | Sat Mar 6 | vs Pitt | W77-62 | 16-6 | .727 | - | | Littlejohn Coliseum · Clemson, SC |
| 28 | Wed Mar 10 | vsMiami | L64-67 | 16-7 | .696 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 29 | Fri Mar 19 | vs #10Rutgers | L56-60 | 16-8 | .667 | #7 | TBS | Littlejohn Coliseum · Clemson, SC |
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