| 1 | Tue Nov 9 | vs Presbyterian | W64-53 | 1-0 | 1.000 | - | | Littlejohn Coliseum · Clemson, SC |
| 2 | Fri Nov 12 | vs Wofford | W76-68 | 2-0 | 1.000 | - | | Littlejohn Coliseum · Clemson, SC |
| 3 | Mon Nov 15 | vs Bryant | W93-70 | 3-0 | 1.000 | - | | Littlejohn Coliseum · Clemson, SC |
| 4 | Thu Nov 18 | at Temple | W75-48 | 4-0 | 1.000 | - | ESPN2 | Liacouras Center · Philadelphia, PA |
| 5 | Fri Nov 19 | vs St Bonaventure | L65-68 | 4-1 | .800 | - | ESPN2 | Littlejohn Coliseum · Clemson, SC |
| 6 | Sun Nov 21 | at West Virginia | L59-66 | 4-2 | .667 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 7 | Fri Nov 26 | vs Charleston So | W91-59 | 5-2 | .714 | - | | Littlejohn Coliseum · Clemson, SC |
| 8 | Tue Nov 30 | at Rutgers | L64-74 | 5-3 | .625 | - | ESPN2 | Jersey Mike’s Arena · Piscataway, NJ |
| 9 | Sat Dec 4 | at Miami | L75-80 | 5-4 | .556 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 10 | Sat Dec 11 | vs Drake | W90-80 (OT) | 6-4 | .600 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 11 | Tue Dec 14 | vs Miami OH | W89-76 | 7-4 | .636 | - | | Littlejohn Coliseum · Clemson, SC |
| 12 | Sat Dec 18 | vs South Carolina | W70-56 | 8-4 | .667 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 13 | Wed Dec 22 | at Virginia | W67-50 | 9-4 | .692 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 14 | Wed Dec 29 | vs #2Duke | PPD | 17-16 | .515 | - | | Littlejohn Coliseum · Clemson, SC |
| 15 | Tue Jan 4 | vsVirginia | L65-75 | 9-5 | .643 | - | | Littlejohn Coliseum · Clemson, SC |
| 16 | Sat Jan 8 | at NC State | W70-65 | 10-5 | .667 | - | | PNC Arena · Raleigh, NC |
| 17 | Wed Jan 12 | at Notre Dame | L56-72 | 10-6 | .625 | - | | Purcell Pavilion · South Bend, IN |
| 18 | Sat Jan 15 | vs Boston College | L68-70 | 10-7 | .588 | - | | Littlejohn Coliseum · Clemson, SC |
| 19 | Tue Jan 18 | at Syracuse | L78-91 | 10-8 | .556 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 20 | Sat Jan 22 | vs Pitt | W75-48 | 11-8 | .579 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 21 | Tue Jan 25 | at#9Duke | L69-71 | 11-9 | .550 | - | ESPN2 | Cameron Indoor Stadium · Durham, NC |
| 22 | Wed Feb 2 | vs Florida St | W75-69 | 12-9 | .571 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 23 | Sat Feb 5 | at Georgia Tech | L64-69 | 12-10 | .545 | - | | McCamish Pavilion · Atlanta, GA |
| 24 | Tue Feb 8 | vs UNC | L77-79 | 12-11 | .522 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 25 | Thu Feb 10 | vs#7Duke | L64-82 | 12-12 | .500 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 26 | Sat Feb 12 | vsNotre Dame | L61-76 | 12-13 | .480 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 27 | Tue Feb 15 | atFlorida St | L80-81 | 12-14 | .462 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 28 | Sat Feb 19 | at Louisville | L61-70 | 12-15 | .444 | - | | KFC Yum! Center · Louisville, KY |
| 29 | Wed Feb 23 | vs Wake Forest | W80-69 | 13-15 | .464 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 30 | Sat Feb 26 | atBoston College | W70-60 | 14-15 | .483 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 31 | Wed Mar 2 | vsGeorgia Tech | W68-65 | 15-15 | .500 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 32 | Sat Mar 5 | vs Virginia Tech | W63-59 | 16-15 | .516 | - | | Littlejohn Coliseum · Clemson, SC |
| 33 | Tue Mar 8 | vsNC State | W70-64 | 17-15 | .531 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 34 | Wed Mar 9 | atVirginia Tech | L75-76 (OT) | 17-16 | .515 | - | ESPN2 | Cassell Coliseum · Blacksburg, VA |
