| 1 | Mon Nov 6 | vs Winthrop | W78-56 | 1-0 | 1.000 | - | | Littlejohn Coliseum · Clemson, SC |
| 2 | Fri Nov 10 | at UAB | W77-76 | 2-0 | 1.000 | - | | Bartow Arena · Birmingham, AL |
| 3 | Sun Nov 12 | vs Davidson | W68-65 | 3-0 | 1.000 | - | ESPN2 | Littlejohn Coliseum · Clemson, SC |
| 4 | Sun Nov 19 | vs Boise St | W85-68 | 4-0 | 1.000 | - | | Littlejohn Coliseum · Clemson, SC |
| 5 | Fri Nov 24 | vs Alcorn St | W90-69 | 5-0 | 1.000 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 6 | Tue Nov 28 | at #23Alabama | W85-77 | 6-0 | 1.000 | - | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 7 | Sun Dec 3 | at Pitt | W79-70 | 7-0 | 1.000 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 8 | Wed Dec 6 | vs South Carolina | W72-67 | 8-0 | 1.000 | #24 | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 9 | Sat Dec 9 | vs TCU | W74-66 | 9-0 | 1.000 | #24 | FS1 | Littlejohn Coliseum · Clemson, SC |
| 10 | Sat Dec 16 | at Memphis | L77-79 | 9-1 | .900 | #13 | | FedExForum · Memphis, TN |
| 11 | Fri Dec 22 | vs Queens | W109-79 | 10-1 | .909 | #18 | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 12 | Fri Dec 29 | vs Radford | W93-58 | 11-1 | .917 | #18 | | Littlejohn Coliseum · Clemson, SC |
| 13 | Wed Jan 3 | at Miami | L82-95 | 11-2 | .846 | #16 | ESPN | Watsco Center · Coral Gables, FL |
| 14 | Sat Jan 6 | vs #8UNC | L55-65 | 11-3 | .786 | #16 | ESPN2 | Littlejohn Coliseum · Clemson, SC |
| 15 | Wed Jan 10 | at Virginia Tech | L72-87 | 11-4 | .733 | #21 | ESPN2 | Cassell Coliseum · Blacksburg, VA |
| 16 | Sat Jan 13 | vs Boston College | W89-78 | 12-4 | .750 | #21 | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 17 | Tue Jan 16 | vs Georgia Tech | L90-93 (2OT) | 12-5 | .706 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 18 | Sat Jan 20 | at Florida St | W78-67 | 13-5 | .722 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 19 | Sat Jan 27 | at #12Duke | L71-72 | 13-6 | .684 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 20 | Tue Jan 30 | vs Louisville | W70-64 | 14-6 | .700 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 21 | Sat Feb 3 | vs Virginia | L65-66 | 14-7 | .667 | - | ESPN | Littlejohn Coliseum · Clemson, SC |
| 22 | Tue Feb 6 | at#3UNC | W80-76 | 15-7 | .682 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 23 | Sat Feb 10 | at Syracuse | W77-68 | 16-7 | .696 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 24 | Wed Feb 14 | vsMiami | W77-60 | 17-7 | .708 | - | ESPN2 | Littlejohn Coliseum · Clemson, SC |
| 25 | Sat Feb 17 | vs NC State | L77-78 | 17-8 | .680 | - | The CW Network | Littlejohn Coliseum · Clemson, SC |
| 26 | Wed Feb 21 | atGeorgia Tech | W81-57 | 18-8 | .692 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 27 | Sat Feb 24 | vsFlorida St | W74-63 | 19-8 | .704 | - | | Littlejohn Coliseum · Clemson, SC |
| 28 | Tue Feb 27 | vsPitt | W69-62 | 20-8 | .714 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 29 | Sat Mar 2 | at Notre Dame | L62-69 | 20-9 | .690 | - | The CW Network | Purcell Pavilion · South Bend, IN |
| 30 | Tue Mar 5 | vsSyracuse | W90-75 | 21-9 | .700 | - | ESPN2 | Littlejohn Coliseum · Clemson, SC |
| 31 | Sat Mar 9 | at Wake Forest | L76-81 | 21-10 | .677 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 32 | Wed Mar 13 | vsBoston College | L55-76 | 21-11 | .656 | - | ESPNU | Littlejohn Coliseum · Clemson, SC |
| 33 | Fri Mar 22 | vs #11New Mexico | W77-56 | 22-11 | .667 | #6 | truTV | Littlejohn Coliseum · Clemson, SC |
| 34 | Sun Mar 24 | at #3Baylor | W72-64 | 23-11 | .676 | #6 | TNT | Ferrell Center · Waco, TX |
| 35 | Thu Mar 28 | at #2Arizona | W77-72 | 24-11 | .686 | #6 | CBS | McKale Center · Tucson, AZ |
| 36 | Sat Mar 30 | at#4Alabama | L82-89 | 24-12 | .667 | #6 | TBS | Coleman Coliseum · Tuscaloosa, AL |
