| 1 | Mon Nov 7 | vs The Citadel | W80-69 | 1-0 | 1.000 | - | | Littlejohn Coliseum · Clemson, SC |
| 2 | Fri Nov 11 | at South Carolina | L58-60 | 1-1 | .500 | - | | Colonial Life Arena · Columbia, SC |
| 3 | Tue Nov 15 | vs SC Upstate | W81-70 | 2-1 | .667 | - | | Littlejohn Coliseum · Clemson, SC |
| 4 | Fri Nov 18 | vs Bellarmine | W76-66 | 3-1 | .750 | - | | Littlejohn Coliseum · Clemson, SC |
| 5 | Mon Nov 21 | vs Loyola MD | W72-41 | 4-1 | .800 | - | | Littlejohn Coliseum · Clemson, SC |
| 6 | Fri Nov 25 | vs Iowa | L71-74 | 4-2 | .667 | - | CBS | Littlejohn Coliseum · Clemson, SC |
| 7 | Sat Nov 26 | at California | W67-59 | 5-2 | .714 | - | | Haas Pavilion · Berkeley, CA |
| 8 | Tue Nov 29 | vs Penn State | W101-94 (2OT) | 6-2 | .750 | - | ESPNU | Littlejohn Coliseum · Clemson, SC |
| 9 | Fri Dec 2 | vs Wake Forest | W77-57 | 7-2 | .778 | - | | Littlejohn Coliseum · Clemson, SC |
| 10 | Wed Dec 7 | vs Towson | W80-75 | 8-2 | .800 | - | | Littlejohn Coliseum · Clemson, SC |
| 11 | Sat Dec 10 | vs Loyola Chicago | L58-76 | 8-3 | .727 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 12 | Sat Dec 17 | vs Richmond | W85-57 | 9-3 | .750 | - | | Littlejohn Coliseum · Clemson, SC |
| 13 | Wed Dec 21 | at Georgia Tech | W79-66 | 10-3 | .769 | - | ESPN2 | McCamish Pavilion · Atlanta, GA |
| 14 | Fri Dec 30 | vs NC State | W78-64 | 11-3 | .786 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 15 | Wed Jan 4 | at Virginia Tech | W68-65 | 12-3 | .800 | - | ESPNU | Cassell Coliseum · Blacksburg, VA |
| 16 | Sat Jan 7 | at Pitt | W75-74 | 13-3 | .813 | - | ESPN2 | Petersen Events Center · Pittsburgh, PA |
| 17 | Wed Jan 11 | vs Louisville | W83-70 | 14-3 | .824 | - | | Littlejohn Coliseum · Clemson, SC |
| 18 | Sat Jan 14 | vs #24Duke | W72-64 | 15-3 | .833 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 19 | Tue Jan 17 | atWake Forest | L77-87 | 15-4 | .789 | #19 | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 20 | Sat Jan 21 | vsVirginia Tech | W51-50 | 16-4 | .800 | #19 | ESPN2 | Littlejohn Coliseum · Clemson, SC |
| 21 | Tue Jan 24 | vsGeorgia Tech | W72-51 | 17-4 | .810 | #24 | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 22 | Sat Jan 28 | at Florida St | W82-81 | 18-4 | .818 | #24 | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 23 | Tue Jan 31 | at Boston College | L54-62 | 18-5 | .783 | #20 | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 24 | Sat Feb 4 | vs #23Miami | L74-78 | 18-6 | .750 | #20 | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 25 | Sat Feb 11 | at UNC | L71-91 | 18-7 | .720 | - | ESPN2 | Dean E. Smith Center · Chapel Hill, NC |
| 26 | Wed Feb 15 | vsFlorida St | W94-54 | 19-7 | .731 | - | | Littlejohn Coliseum · Clemson, SC |
| 27 | Sat Feb 18 | atLouisville | L73-83 | 19-8 | .704 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 28 | Wed Feb 22 | vs Syracuse | W91-73 | 20-8 | .714 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 29 | Sat Feb 25 | atNC State | W96-71 | 21-8 | .724 | - | | PNC Arena · Raleigh, NC |
| 30 | Tue Feb 28 | at #13Virginia | L57-64 | 21-9 | .700 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 31 | Sat Mar 4 | vs Notre Dame | W87-64 | 22-9 | .710 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 32 | Thu Mar 9 | vsNC State | W80-54 | 23-9 | .719 | - | ESPN | Littlejohn Coliseum · Clemson, SC |
| 33 | Fri Mar 10 | atVirginia | L56-76 | 23-10 | .697 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 34 | Wed Mar 15 | vs Morehead St | L64-68 | 23-11 | .676 | - | | Littlejohn Coliseum · Clemson, SC |
