| 1 | Tue Nov 5 | vs Virginia Tech | L60-67 | 0-1 | .000 | - | ESPNU | Littlejohn Coliseum · Clemson, SC |
| 2 | Thu Nov 7 | vsPresbyterian | W79-45 | 1-1 | .500 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 3 | Sun Nov 10 | vsColgate | W81-68 | 2-1 | .667 | - | | Littlejohn Coliseum · Clemson, SC |
| 4 | Sun Nov 17 | vsDetroit Mercy | W87-65 | 3-1 | .750 | - | | Littlejohn Coliseum · Clemson, SC |
| 5 | Thu Nov 21 | vsAlabama A&M | W87-51 | 4-1 | .800 | - | | Littlejohn Coliseum · Clemson, SC |
| 6 | Sun Nov 24 | vsTCU | W62-60 (OT) | 5-1 | .833 | - | ESPN2 | T-Mobile Arena · Las Vegas, NV |
| 7 | Tue Nov 26 | vsColorado | L67-71 | 5-2 | .714 | - | ESPN2 | T-Mobile Arena · Las Vegas, NV |
| 8 | Mon Dec 2 | atMinnesota | L60-78 | 5-3 | .625 | - | ESPN2 | Williams Arena · Minneapolis, MN |
| 9 | Sun Dec 8 | at#17Florida St | L53-72 | 5-4 | .556 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 10 | Sun Dec 15 | vsSouth Carolina | L54-67 | 5-5 | .500 | - | ESPN2 | Littlejohn Coliseum · Clemson, SC |
| 11 | Fri Dec 20 | vsJacksonville | W68-39 | 6-5 | .545 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 12 | Sun Dec 22 | vsYale | L45-54 | 6-6 | .500 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 13 | Tue Dec 31 | vsMiami | L68-73 (OT) | 6-7 | .462 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 14 | Sat Jan 4 | vsNC State | W81-70 | 7-7 | .500 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 15 | Sat Jan 11 | atUNC | W79-76 (OT) | 8-7 | .533 | - | | Dean E. Smith Center · Chapel Hill, NC |
| 16 | Tue Jan 14 | vs#3Duke | W79-72 | 9-7 | .563 | - | ESPN | Littlejohn Coliseum · Clemson, SC |
| 17 | Sat Jan 18 | atNC State | L54-60 | 9-8 | .529 | - | | PNC Arena · Raleigh, NC |
| 18 | Tue Jan 21 | vsWake Forest | W71-68 | 10-8 | .556 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 19 | Sat Jan 25 | at#6Louisville | L62-80 | 10-9 | .526 | - | | KFC Yum! Center · Louisville, KY |
| 20 | Tue Jan 28 | vsSyracuse | W71-70 | 11-9 | .550 | - | | Littlejohn Coliseum · Clemson, SC |
| 21 | Sat Feb 1 | atWake Forest | L44-56 | 11-10 | .524 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 22 | Wed Feb 5 | atVirginia | L44-51 | 11-11 | .500 | - | | John Paul Jones Arena · Charlottesville, VA |
| 23 | Sun Feb 9 | vsNotre Dame | L57-61 | 11-12 | .478 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 24 | Wed Feb 12 | atPitt | W72-52 | 12-12 | .500 | - | | Petersen Events Center · Pittsburgh, PA |
| 25 | Sat Feb 15 | vs#5Louisville | W77-62 | 13-12 | .520 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 26 | Sat Feb 22 | atBoston College | W82-64 | 14-12 | .538 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 27 | Tue Feb 25 | atGeorgia Tech | L59-68 | 14-13 | .519 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 28 | Sat Feb 29 | vs#6Florida St | W70-69 | 15-13 | .536 | - | | Littlejohn Coliseum · Clemson, SC |
| 29 | Wed Mar 4 | atVirginia Tech | L58-70 | 15-14 | .517 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 30 | Fri Mar 6 | vsGeorgia Tech | L62-65 | 15-15 | .500 | - | ESPN2 | Littlejohn Coliseum · Clemson, SC |
| 31 | Wed Mar 11 | vsMiami | W69-64 | 16-15 | .516 | - | ESPN | Greensboro Coliseum · Greensboro, NC |
