| 1 | Mon Nov 4 | vs Fairleigh | W113-72 | 1-0 | 1.000 | - | ESPN+ | Watsco Center · Coral Gables, FL |
| 2 | Sun Nov 10 | vsBinghamton | W88-64 | 2-0 | 1.000 | - | ESPN+ | Watsco Center · Coral Gables, FL |
| 3 | Sun Nov 17 | vsCoppin St | W93-63 | 3-0 | 1.000 | - | ESPN+ | Watsco Center · Coral Gables, FL |
| 4 | Thu Nov 21 | atDrake | L69-80 | 3-1 | .750 | - | ESPN2 | TD Arena · Charleston, SC |
| 5 | Fri Nov 22 | atOklahoma St | L74-80 | 3-2 | .600 | - | ESPNU | TD Arena · Charleston, SC |
| 6 | Sun Nov 24 | atVCU | L70-77 | 3-3 | .500 | - | ESPN+ | TD Arena · Charleston, SC |
| 7 | Sat Nov 30 | vsCharleston So | L79-83 | 3-4 | .429 | - | ESPN+ | Watsco Center · Coral Gables, FL |
| 8 | Tue Dec 3 | vsArkansas | L73-76 | 3-5 | .375 | - | ESPN2 | Watsco Center · Coral Gables, FL |
| 9 | Sat Dec 7 | vsClemson | L55-65 | 3-6 | .333 | - | ESPN2 | Watsco Center · Coral Gables, FL |
| 10 | Tue Dec 10 | at1Tennessee | L62-75 | 3-7 | .300 | - | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 11 | Sun Dec 15 | vsPresbyterian | W94-75 | 4-7 | .364 | - | ESPN+ | Watsco Center · Coral Gables, FL |
| 12 | Sat Dec 21 | vsMount St Mary | L74-78 (OT) | 4-8 | .333 | - | ESPN+ | Watsco Center · Coral Gables, FL |
| 13 | Wed Jan 1 | atBoston College | L68-78 | 4-9 | .308 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 14 | Sat Jan 4 | atVirginia Tech | L85-86 | 4-10 | .286 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 15 | Wed Jan 8 | vsFlorida St | L65-80 | 4-11 | .267 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 16 | Sat Jan 11 | vsWake Forest | L78-88 | 4-12 | .250 | - | The CW Network | Watsco Center · Coral Gables, FL |
| 17 | Tue Jan 14 | at3Duke | L54-89 | 4-13 | .235 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 18 | Sat Jan 18 | vsSMU | L74-117 | 4-14 | .222 | - | ESPNU | Watsco Center · Coral Gables, FL |
| 19 | Wed Jan 22 | atStanford | L51-88 | 4-15 | .211 | - | ESPNU | Maples Pavilion · Stanford, CA |
| 20 | Sat Jan 25 | atCalifornia | L94-98 (OT) | 4-16 | .200 | - | ESPNU | Haas Pavilion · Berkeley, CA |
| 21 | Wed Jan 29 | vsVirginia | L71-82 | 4-17 | .190 | - | ESPNU | Watsco Center · Coral Gables, FL |
| 22 | Sat Feb 1 | vsNotre Dame | W63-57 | 5-17 | .227 | - | ESPN2 | Watsco Center · Coral Gables, FL |
| 23 | Sat Feb 8 | atLouisville | L78-88 | 5-18 | .217 | - | ESPN2 | KFC Yum! Center · Louisville, KY |
| 24 | Tue Feb 11 | vsSyracuse | W91-84 | 6-18 | .250 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 25 | Sat Feb 15 | atPitt | L65-74 | 6-19 | .240 | - | ESPN2 | Petersen Events Center · Pittsburgh, PA |
| 26 | Wed Feb 19 | atFlorida St | L66-74 | 6-20 | .231 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 27 | Sat Feb 22 | vsVirginia Tech | L68-81 | 6-21 | .222 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 28 | Tue Feb 25 | vs2Duke | L60-97 | 6-22 | .214 | - | ESPN | Watsco Center · Coral Gables, FL |
| 29 | Sat Mar 1 | atUNC | L73-92 | 6-23 | .207 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 30 | Tue Mar 4 | atGeorgia Tech | L74-89 | 6-24 | .200 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 31 | Sat Mar 8 | vsNC State | W72-70 | 7-24 | .226 | - | The CW Network | Watsco Center · Coral Gables, FL |
