| 1 | Tue Nov 9 | vs SC State | W70-62 | 1-0 | 1.000 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 2 | Fri Nov 12 | vsCanisius | W83-71 | 2-0 | 1.000 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 3 | Sun Nov 14 | vsW Carolina | W95-79 | 3-0 | 1.000 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 4 | Thu Nov 18 | vsOklahoma | L74-79 | 3-1 | .750 | - | ESPNU | The HTC Center · Conway, SC |
| 5 | Fri Nov 19 | atOld Dominion | W73-60 | 4-1 | .800 | - | ESPNU | The HTC Center · Conway, SC |
| 6 | Sun Nov 21 | vsDavidson | L67-76 | 4-2 | .667 | - | ESPNU | The HTC Center · Conway, SC |
| 7 | Sat Nov 27 | vsCoppin St | W70-68 | 5-2 | .714 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 8 | Tue Nov 30 | vsOld Dominion | W63-62 | 6-2 | .750 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 9 | Sat Dec 4 | vsGardner-Webb | W62-52 | 7-2 | .778 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 10 | Tue Dec 7 | vsNC A&T | W82-71 | 8-2 | .800 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 11 | Fri Dec 17 | vsLiberty | L64-74 | 8-3 | .727 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 12 | Tue Dec 21 | vsSouthern Miss | W68-67 | 9-3 | .750 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 14 | Sat Jan 1 | atSouth Florida | PPD | 15-15 | .500 | - | | Yuengling Center · Tampa, FL |
| 15 | Wed Jan 5 | vsTulane | W88-80 (OT) | 10-3 | .769 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 16 | Sat Jan 8 | atTemple | L75-78 | 10-4 | .714 | - | | Liacouras Center · Philadelphia, PA |
| 17 | Wed Jan 12 | atCincinnati | L71-79 | 10-5 | .667 | - | | Fifth Third Arena · Cincinnati, OH |
| 18 | Sat Jan 15 | vsMemphis | W72-71 | 11-5 | .688 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 19 | Tue Jan 18 | vsUCF | L85-92 (OT) | 11-6 | .647 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 20 | Sat Jan 22 | at10Houston | L36-79 | 11-7 | .611 | - | | Fertitta Center · Houston, TX |
| 21 | Thu Jan 27 | atMemphis | L54-71 | 11-8 | .579 | - | ESPN2 | FedExForum · Memphis, TN |
| 22 | Sun Jan 30 | vsCincinnati | L59-60 | 11-9 | .550 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 23 | Wed Feb 2 | vsTemple | L63-71 | 11-10 | .524 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 24 | Sat Feb 5 | atTulane | L66-86 | 11-11 | .500 | - | | Devlin Fieldhouse · New Orleans, LA |
| 25 | Tue Feb 8 | atTulsa | W73-71 | 12-11 | .522 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 26 | Sat Feb 12 | vsSMU | L66-80 | 12-12 | .500 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 27 | Thu Feb 17 | atSouth Florida | W65-57 | 13-12 | .520 | - | | Yuengling Center · Tampa, FL |
| 28 | Sun Feb 20 | atUCF | L66-69 | 13-13 | .500 | - | | Addition Financial Arena · Orlando, FL |
| 29 | Wed Feb 23 | vsSouth Florida | W64-60 | 14-13 | .519 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 30 | Sat Feb 26 | vsTulsa | W64-59 | 15-13 | .536 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 31 | Sat Mar 5 | atWichita St | L62-70 | 15-14 | .517 | - | ESPNU | Charles Koch Arena · Wichita, KS |
| 32 | Thu Mar 10 | atCincinnati | L63-74 | 15-15 | .500 | - | ESPNU | Fifth Third Arena · Cincinnati, OH |
