| 1 | Mon Nov 6 | at Xavier | L63-77 | 0-1 | .000 | - | | Cintas Center · Cincinnati, OH |
| 2 | Thu Nov 9 | vsTBD | W66-56 | 1-1 | .500 | - | | UPMC Events Center · Moon Township, PA |
| 3 | Sun Nov 12 | atTowson | L62-66 | 1-2 | .333 | - | | SECU Arena · Towson, MD |
| 4 | Fri Nov 17 | atWisconsin | L68-78 | 1-3 | .250 | - | | Kohl Center · Madison, WI |
| 5 | Fri Nov 24 | vsJacksonville | L65-74 | 1-4 | .200 | - | | UPMC Events Center · Moon Township, PA |
| 6 | Sun Nov 26 | vsFairleigh | W97-86 | 2-4 | .333 | - | | UPMC Events Center · Moon Township, PA |
| 7 | Wed Nov 29 | atN Kentucky | L59-77 | 2-5 | .286 | - | | Truist Arena · Highland Heights, KY |
| 8 | Sat Dec 2 | vsYoungstown St | L57-71 | 2-6 | .250 | - | | UPMC Events Center · Moon Township, PA |
| 9 | Wed Dec 6 | atCanisius | L80-87 | 2-7 | .222 | - | | Koessler Athletic Center · Buffalo, NY |
| 10 | Mon Dec 11 | vsDelaware | L69-73 | 2-8 | .200 | - | | UPMC Events Center · Moon Township, PA |
| 11 | Sun Dec 17 | vsTBD | W95-46 | 3-8 | .273 | - | | UPMC Events Center · Moon Township, PA |
| 12 | Wed Dec 20 | atSt Francis PA | W75-73 | 4-8 | .333 | - | | DeGol Arena · Loretto, PA |
| 13 | Fri Dec 22 | vsCornell | L85-90 | 4-9 | .308 | - | | UPMC Events Center · Moon Township, PA |
| 14 | Fri Dec 29 | atMilwaukee | L75-78 | 4-10 | .286 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 15 | Sun Dec 31 | atGreen Bay | L61-78 | 4-11 | .267 | - | | Resch Center · Ashwaubenon, WI |
| 16 | Thu Jan 4 | vsIU Indy | W92-48 | 5-11 | .313 | - | | UPMC Events Center · Moon Township, PA |
| 17 | Wed Jan 10 | vsWright St | L76-101 | 5-12 | .294 | - | | UPMC Events Center · Moon Township, PA |
| 18 | Fri Jan 12 | vsPurdue FW | W91-88 (OT) | 6-12 | .333 | - | | UPMC Events Center · Moon Township, PA |
| 19 | Wed Jan 17 | vsDetroit Mercy | W102-99 (2OT) | 7-12 | .368 | - | | UPMC Events Center · Moon Township, PA |
| 20 | Sat Jan 20 | atIU Indy | W80-63 | 8-12 | .400 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 21 | Sun Jan 28 | atCleveland St | L64-66 | 8-13 | .381 | - | | Wolstein Center · Cleveland, OH |
| 22 | Thu Feb 1 | atOakland | L72-87 | 8-14 | .364 | - | | Athletics Center O'rena · Rochester, MI |
| 23 | Sat Feb 3 | atDetroit Mercy | W75-67 | 9-14 | .391 | - | | Calihan Hall · Detroit, MI |
| 24 | Thu Feb 8 | vsGreen Bay | L76-81 (OT) | 9-15 | .375 | - | | UPMC Events Center · Moon Township, PA |
| 25 | Sat Feb 10 | vsMilwaukee | W71-60 | 10-15 | .400 | - | | UPMC Events Center · Moon Township, PA |
| 26 | Wed Feb 14 | atYoungstown St | L77-87 | 10-16 | .385 | - | | Beeghly Center · Youngstown, OH |
| 27 | Sat Feb 17 | atWright St | L71-101 | 10-17 | .370 | - | | Nutter Center · Dayton, OH |
| 28 | Thu Feb 22 | vsOakland | L43-63 | 10-18 | .357 | - | | UPMC Events Center · Moon Township, PA |
| 29 | Sun Feb 25 | vsCleveland St | L71-73 | 10-19 | .345 | - | | UPMC Events Center · Moon Township, PA |
| 30 | Wed Feb 28 | vsN Kentucky | L60-70 | 10-20 | .333 | - | | UPMC Events Center · Moon Township, PA |
| 31 | Sat Mar 2 | atPurdue FW | L65-83 | 10-21 | .323 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 32 | Tue Mar 5 | atPurdue FW | L63-78 | 10-22 | .313 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
