| 1 | Tue Nov 7 | at DePaul | W82-74 | 1-0 | 1.000 | - | FS2 | Wintrust Arena · Chicago, IL |
| 2 | Thu Nov 9 | vsTBD | W130-34 | 2-0 | 1.000 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 3 | Sun Nov 12 | vsE Texas A&M | W86-64 | 3-0 | 1.000 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 4 | Fri Nov 17 | atN Arizona | W77-67 | 4-0 | 1.000 | - | | J. Lawrence Walkup Skydome · Flagstaff, AZ |
| 5 | Sat Nov 18 | atSouth Dakota | W93-81 | 5-0 | 1.000 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 6 | Wed Nov 22 | atSan Francisco | L60-76 | 5-1 | .833 | - | | War Memorial at the Sobrato Center · San Francisco, CA |
| 7 | Sat Nov 25 | vsTBD | W95-64 | 6-1 | .857 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 8 | Wed Nov 29 | vsGreen Bay | W75-71 | 7-1 | .875 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 9 | Sat Dec 2 | atOakland | W98-77 | 8-1 | .889 | - | | Athletics Center O'rena · Rochester, MI |
| 10 | Wed Dec 6 | atSo Indiana | W70-57 | 9-1 | .900 | - | | Screaming Eagles Arena · Evansville, IN |
| 11 | Sat Dec 9 | vsSE Missouri St | W89-80 | 10-1 | .909 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 12 | Sat Dec 16 | vsBethune | W86-63 | 11-1 | .917 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 13 | Wed Dec 20 | atPitt | L48-62 | 11-2 | .846 | - | | Petersen Events Center · Pittsburgh, PA |
| 14 | Fri Dec 29 | vsN Kentucky | W73-60 | 12-2 | .857 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 15 | Sun Dec 31 | vsDetroit Mercy | W91-56 | 13-2 | .867 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 16 | Sat Jan 6 | vsWright St | L98-106 | 13-3 | .813 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 17 | Wed Jan 10 | atYoungstown St | L85-93 | 13-4 | .765 | - | | Beeghly Center · Youngstown, OH |
| 18 | Fri Jan 12 | atRobert Morris | L88-91 (OT) | 13-5 | .722 | - | | UPMC Events Center · Moon Township, PA |
| 19 | Wed Jan 17 | vsIU Indy | L79-85 | 13-6 | .684 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 20 | Sat Jan 20 | atCleveland St | L68-75 | 13-7 | .650 | - | | Wolstein Center · Cleveland, OH |
| 21 | Thu Jan 25 | atN Kentucky | W63-58 | 14-7 | .667 | - | ESPNU | Truist Arena · Highland Heights, KY |
| 22 | Thu Feb 1 | vsMilwaukee | L65-68 | 14-8 | .636 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 23 | Sun Feb 4 | vsYoungstown St | W82-78 | 15-8 | .652 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 24 | Wed Feb 7 | vsCleveland St | L72-75 | 15-9 | .625 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 25 | Sat Feb 10 | atIU Indy | W92-65 | 16-9 | .640 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 26 | Wed Feb 14 | vsOakland | L63-71 | 16-10 | .615 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 27 | Sat Feb 17 | atDetroit Mercy | W83-69 | 17-10 | .630 | - | | Calihan Hall · Detroit, MI |
| 28 | Fri Feb 23 | atGreen Bay | W85-59 | 18-10 | .643 | - | | Resch Center · Ashwaubenon, WI |
| 29 | Sun Feb 25 | atMilwaukee | L88-96 | 18-11 | .621 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 30 | Wed Feb 28 | atWright St | W79-77 (OT) | 19-11 | .633 | - | | Nutter Center · Dayton, OH |
| 31 | Sat Mar 2 | vsRobert Morris | W83-65 | 20-11 | .645 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 32 | Tue Mar 5 | vsRobert Morris | W78-63 | 21-11 | .656 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 33 | Thu Mar 7 | atOakland | L65-75 | 21-12 | .636 | - | | Athletics Center O'rena · Rochester, MI |
| 34 | Wed Mar 20 | atBowling Green | W77-75 | 22-12 | .647 | - | | Stroh Center · Bowling Green, OH |
| 35 | Mon Mar 25 | atTarleton | W73-72 | 23-12 | .657 | - | | placeholder · sf, ca |
| 36 | Wed Mar 27 | atNorfolk St | L67-75 | 23-13 | .639 | - | | Joseph G. Echols Hall · Norfolk, VA |
