| 1 | Tue Nov 9 | vs SE Missouri St | L94-99 | 0-1 | .000 | - | | Great Southern Bank Arena · Springfield, MO |
| 2 | Sat Nov 13 | vs Alabama St | W78-60 | 1-1 | .500 | - | | Great Southern Bank Arena · Springfield, MO |
| 3 | Wed Nov 17 | at Sam Houston | W77-55 | 2-1 | .667 | - | | Bernard G. Johnson Coliseum · Huntsville, TX |
| 4 | Mon Nov 22 | vs Long Beach St | W92-66 | 3-1 | .750 | - | | Great Southern Bank Arena · Springfield, MO |
| 5 | Tue Nov 23 | at ETSU | L76-77 | 3-2 | .600 | - | | Freedom Hall Civic Center · Johnson City, TN |
| 6 | Wed Nov 24 | at G Washington | W72-54 | 4-2 | .667 | - | | Charles E. Smith Center · Washington, D.C. |
| 7 | Wed Dec 1 | at Illinois St | L74-79 (OT) | 4-3 | .571 | - | | Redbird Arena · Normal, IL |
| 8 | Sat Dec 4 | vs #12BYU | L68-74 | 4-4 | .500 | - | CBS | Great Southern Bank Arena · Springfield, MO |
| 9 | Wed Dec 8 | at Little Rock | W81-55 | 5-4 | .556 | - | | Jack Stephens Center · Little Rock, AR |
| 10 | Sat Dec 11 | vs Oral Roberts | W69-60 | 6-4 | .600 | - | | Great Southern Bank Arena · Springfield, MO |
| 11 | Wed Dec 15 | vs S Dakota St | W75-63 | 7-4 | .636 | - | | Great Southern Bank Arena · Springfield, MO |
| 12 | Sat Dec 18 | vs C Arkansas | W106-70 | 8-4 | .667 | - | | Great Southern Bank Arena · Springfield, MO |
| 13 | Wed Dec 22 | at Saint Mary's | L58-75 | 8-5 | .615 | - | | University Credit Union Pavilion · Moraga, CA |
| 14 | Thu Dec 30 | vs TBD | W103-56 | 9-5 | .643 | - | | Great Southern Bank Arena · Springfield, MO |
| 15 | Sun Jan 2 | vs Drake | W61-56 | 10-5 | .667 | - | | Great Southern Bank Arena · Springfield, MO |
| 16 | Wed Jan 5 | at Bradley | W71-69 | 11-5 | .688 | - | | Carver Arena · Peoria, IL |
| 17 | Sat Jan 8 | vs Northern Iowa | L84-85 | 11-6 | .647 | - | CBS | Great Southern Bank Arena · Springfield, MO |
| 18 | Wed Jan 12 | vs S Illinois | W81-76 | 12-6 | .667 | - | | Great Southern Bank Arena · Springfield, MO |
| 19 | Sat Jan 15 | at Valparaiso | W74-57 | 13-6 | .684 | - | ESPNU | Athletics-Recreation Center · Valparaiso, IN |
| 20 | Wed Jan 19 | vsIllinois St | W88-63 | 14-6 | .700 | - | | Great Southern Bank Arena · Springfield, MO |
| 21 | Sat Jan 22 | at #22Loyola Chicago | W79-69 | 15-6 | .714 | - | CBS | Joseph J. Gentile Arena · Chicago, IL |
| 22 | Tue Jan 25 | at Indiana St | L72-76 | 15-7 | .682 | - | | Hulman Center · Terre Haute, IN |
| 23 | Sat Jan 29 | vs Evansville | W72-58 | 16-7 | .696 | - | | Great Southern Bank Arena · Springfield, MO |
| 24 | Wed Feb 2 | atS Illinois | W69-54 | 17-7 | .708 | - | | Banterra Center · Carbondale, IL |
| 25 | Sun Feb 6 | vsLoyola Chicago | L62-71 | 17-8 | .680 | - | ESPN2 | Great Southern Bank Arena · Springfield, MO |
| 26 | Wed Feb 9 | atDrake | W66-62 | 18-8 | .692 | - | | The Knapp Center · Des Moines, IA |
| 27 | Sat Feb 12 | vsValparaiso | W84-66 | 19-8 | .704 | - | | Great Southern Bank Arena · Springfield, MO |
| 28 | Tue Feb 15 | vsIndiana St | W79-70 | 20-8 | .714 | - | | Great Southern Bank Arena · Springfield, MO |
| 29 | Sun Feb 20 | atNorthern Iowa | L75-95 | 20-9 | .690 | - | ESPNU | McLeod Center · Cedar Falls, IA |
| 30 | Wed Feb 23 | vsBradley | W83-67 | 21-9 | .700 | - | | Great Southern Bank Arena · Springfield, MO |
| 31 | Sat Feb 26 | atEvansville | W88-79 | 22-9 | .710 | - | | Ford Center · Evansville, IN |
| 32 | Fri Mar 4 | vsValparaiso | W67-58 | 23-9 | .719 | - | | Great Southern Bank Arena · Springfield, MO |
| 33 | Sat Mar 5 | vsDrake | L78-79 (OT) | 23-10 | .697 | - | CBS | Great Southern Bank Arena · Springfield, MO |
| 34 | Tue Mar 15 | at Oklahoma | L72-89 | 23-11 | .676 | - | ESPN | Lloyd Noble Center · Norman, OK |
