| 1 | Tue Nov 5 | vs Little Rock | L66-67 | 0-1 | .000 | - | | Great Southern Bank Arena · Springfield, MO |
| 2 | Sun Nov 10 | vs Alabama St | W59-50 | 1-1 | .500 | - | | Great Southern Bank Arena · Springfield, MO |
| 3 | Tue Nov 12 | vs Cleveland St | W73-53 | 2-1 | .667 | - | | Great Southern Bank Arena · Springfield, MO |
| 4 | Fri Nov 15 | at #21Xavier | L56-59 | 2-2 | .500 | - | | Cintas Center · Cincinnati, OH |
| 5 | Thu Nov 21 | at Miami | L70-74 | 2-3 | .400 | - | ESPNU | Watsco Center · Coral Gables, FL |
| 6 | Fri Nov 22 | at Saint Joseph's | W71-69 | 3-3 | .500 | - | ESPNU | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 7 | Sun Nov 24 | at Buffalo | L74-75 | 3-4 | .429 | - | ESPNU | Alumni Arena · Buffalo, NY |
| 8 | Fri Nov 29 | at LSU | L58-73 | 3-5 | .375 | - | | Pete Maravich Assembly Center · Baton Rouge, LA |
| 9 | Tue Dec 3 | vs Murray St | W71-69 | 4-5 | .444 | - | | Great Southern Bank Arena · Springfield, MO |
| 10 | Fri Dec 6 | vs Miss Valley St | W86-62 | 5-5 | .500 | - | | Great Southern Bank Arena · Springfield, MO |
| 11 | Wed Dec 11 | vs Arkansas St | W75-53 | 6-5 | .545 | - | | Great Southern Bank Arena · Springfield, MO |
| 12 | Sun Dec 15 | at VCU | L51-61 | 6-6 | .500 | - | | Stuart C. Siegel Center · Richmond, VA |
| 13 | Sat Dec 21 | at Oral Roberts | L72-82 | 6-7 | .462 | - | | Mabee Center · Tulsa, OK |
| 14 | Tue Dec 31 | vs Evansville | W65-52 | 7-7 | .500 | - | | Great Southern Bank Arena · Springfield, MO |
| 15 | Sat Jan 4 | at Loyola Chicago | L58-62 | 7-8 | .467 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 16 | Tue Jan 7 | at Illinois St | W67-63 | 8-8 | .500 | - | | Redbird Arena · Normal, IL |
| 17 | Sat Jan 11 | vs Northern Iowa | L57-80 | 8-9 | .471 | - | | Great Southern Bank Arena · Springfield, MO |
| 18 | Wed Jan 15 | vs Bradley | L78-91 | 8-10 | .444 | - | | Great Southern Bank Arena · Springfield, MO |
| 19 | Sat Jan 18 | atEvansville | W68-58 | 9-10 | .474 | - | | Ford Center · Evansville, IN |
| 20 | Thu Jan 23 | vs Valparaiso | W67-60 | 10-10 | .500 | - | CBS | Great Southern Bank Arena · Springfield, MO |
| 21 | Sun Jan 26 | at Drake | L69-71 | 10-11 | .476 | - | | The Knapp Center · Des Moines, IA |
| 22 | Wed Jan 29 | atNorthern Iowa | L66-95 | 10-12 | .455 | - | | McLeod Center · Cedar Falls, IA |
| 23 | Sat Feb 1 | vs Indiana St | L68-78 | 10-13 | .435 | - | | Great Southern Bank Arena · Springfield, MO |
| 24 | Wed Feb 5 | vsIllinois St | W80-60 | 11-13 | .458 | - | | Great Southern Bank Arena · Springfield, MO |
| 25 | Sat Feb 8 | at S Illinois | L66-68 | 11-14 | .440 | - | | Banterra Center · Carbondale, IL |
| 26 | Wed Feb 12 | vsDrake | W97-62 | 12-14 | .462 | - | | Great Southern Bank Arena · Springfield, MO |
| 27 | Sun Feb 16 | atIndiana St | W71-58 | 13-14 | .481 | - | ESPNU | Hulman Center · Terre Haute, IN |
| 28 | Wed Feb 19 | atBradley | L79-83 (OT) | 13-15 | .464 | - | | Carver Arena · Peoria, IL |
| 29 | Sat Feb 22 | vsLoyola Chicago | W74-62 | 14-15 | .483 | - | CBS | Great Southern Bank Arena · Springfield, MO |
| 30 | Tue Feb 25 | atValparaiso | L74-89 | 14-16 | .467 | - | | Athletics-Recreation Center · Valparaiso, IN |
| 31 | Sat Feb 29 | vsS Illinois | W84-59 | 15-16 | .484 | - | | Great Southern Bank Arena · Springfield, MO |
| 32 | Fri Mar 6 | atIndiana St | W78-51 | 16-16 | .500 | - | | Hulman Center · Terre Haute, IN |
| 33 | Sat Mar 7 | vsValparaiso | L82-89 | 16-17 | .485 | - | CBS | Great Southern Bank Arena · Springfield, MO |
