| 1 | Mon Nov 4 | at S Illinois | W90-80 | 1-0 | 1.000 | - | | Banterra Center · Carbondale, IL |
| 2 | Fri Nov 8 | vs South Florida | W86-71 | 2-0 | 1.000 | - | FloSports | TD Arena · Charleston, SC |
| 3 | Fri Nov 15 | vs FAU | W119-116 (2OT) | 3-0 | 1.000 | - | | TD Arena · Charleston, SC |
| 4 | Sun Nov 17 | vs Liberty | L47-68 | 3-1 | .750 | - | | TD Arena · Charleston, SC |
| 5 | Wed Nov 20 | at The Citadel | W76-61 | 4-1 | .800 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 6 | Sun Nov 24 | at Rhode Island | L53-91 | 4-2 | .667 | - | ESPN+ | Ryan Center · Kingston, RI |
| 7 | Wed Nov 27 | vs N Kentucky | W79-64 | 5-2 | .714 | - | | TD Arena · Charleston, SC |
| 8 | Tue Dec 3 | vs TBD | W94-71 | 6-2 | .750 | - | | TD Arena · Charleston, SC |
| 9 | Tue Dec 10 | at Saint Joseph's | W78-75 | 7-2 | .778 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 10 | Mon Dec 16 | vs Wofford | W77-67 | 8-2 | .800 | - | | TD Arena · Charleston, SC |
| 11 | Sun Dec 22 | vs Oregon St | L65-74 | 8-3 | .727 | - | ESPN2 | TD Arena · Charleston, SC |
| 12 | Mon Dec 23 | at Loyola Chicago | W77-68 | 9-3 | .750 | - | ESPNU | Joseph J. Gentile Arena · Chicago, IL |
| 13 | Wed Dec 25 | at Charlotte | W84-81 | 10-3 | .769 | - | ESPNU | Dale F. Halton Arena · Charlotte, NC |
| 14 | Thu Jan 2 | vs Hampton | W94-67 | 11-3 | .786 | - | | TD Arena · Charleston, SC |
| 15 | Sat Jan 4 | vs Towson | W77-69 | 12-3 | .800 | - | | TD Arena · Charleston, SC |
| 16 | Thu Jan 9 | at Hofstra | W67-61 | 13-3 | .813 | - | | David S. Mack Sports and Exhibition Complex · Hempstead, NY |
| 17 | Sat Jan 11 | at Monmouth | L73-84 | 13-4 | .765 | - | | OceanFirst Bank Center · West Long Branch, NJ |
| 18 | Thu Jan 16 | at Campbell | W67-61 | 14-4 | .778 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 19 | Sat Jan 18 | vs Northeastern | W87-85 | 15-4 | .789 | - | | TD Arena · Charleston, SC |
| 20 | Thu Jan 23 | vs UNC Wilmington | L83-85 | 15-5 | .750 | - | | TD Arena · Charleston, SC |
| 21 | Sat Jan 25 | at Elon | W76-62 | 16-5 | .762 | - | | Schar Center · Elon, NC |
| 22 | Thu Jan 30 | vs Stony Brook | W81-74 | 17-5 | .773 | - | CBS | TD Arena · Charleston, SC |
| 23 | Mon Feb 3 | at William & Mary | L75-90 | 17-6 | .739 | - | CBS | Kaplan Arena · Williamsburg, VA |
| 24 | Thu Feb 6 | vs NC A&T | W66-63 | 18-6 | .750 | - | CBS | TD Arena · Charleston, SC |
| 25 | Sat Feb 8 | vsElon | W88-83 (OT) | 19-6 | .760 | - | | TD Arena · Charleston, SC |
| 26 | Thu Feb 13 | atUNC Wilmington | L66-86 | 19-7 | .731 | - | CBS | Trask Coliseum · Wilmington, NC |
| 27 | Sat Feb 15 | atNC A&T | W69-59 | 20-7 | .741 | - | | Corbett Sports Center · Greensboro, NC |
| 28 | Thu Feb 20 | atNortheastern | W73-62 | 21-7 | .750 | - | | Matthews Arena · Boston, MA |
