| 1 | Tue Nov 5 | vs SC Upstate | W74-55 | 1-0 | 1.000 | - | | TD Arena · Charleston, SC |
| 2 | Sat Nov 9 | vsGeorgia St | W84-80 | 2-0 | 1.000 | - | | TD Arena · Charleston, SC |
| 3 | Wed Nov 13 | vsOklahoma St | L54-73 | 2-1 | .667 | - | CBSSN | TD Arena · Charleston, SC |
| 4 | Tue Nov 19 | atMarshall | W76-66 | 3-1 | .750 | - | | Cam Henderson Center · Huntington, WV |
| 5 | Sat Nov 23 | atUCF | L71-72 | 3-2 | .600 | - | | Addition Financial Arena · Orlando, FL |
| 6 | Thu Nov 28 | vsWake Forest | L56-65 | 3-3 | .500 | - | ESPNEWS | TD Arena · Charleston, SC |
| 7 | Fri Nov 29 | vsProvidence | W63-55 | 4-3 | .571 | - | ESPNU | TD Arena · Charleston, SC |
| 8 | Sun Dec 1 | atUCF | L56-77 | 4-4 | .500 | - | ESPNU | Addition Financial Arena · Orlando, FL |
| 9 | Sun Dec 8 | vsTBD | W76-50 | 5-4 | .556 | - | | TD Arena · Charleston, SC |
| 10 | Sat Dec 14 | atRichmond | L71-78 | 5-5 | .500 | - | NBCSN | Robins Center · Richmond, VA |
| 11 | Wed Dec 18 | vsVCU | L71-76 | 5-6 | .455 | - | | TD Arena · Charleston, SC |
| 12 | Sat Dec 21 | vsSC State | W73-61 | 6-6 | .500 | - | | TD Arena · Charleston, SC |
| 13 | Sat Dec 28 | atDrexel | W76-65 | 7-6 | .538 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 14 | Mon Dec 30 | atDelaware | W75-63 | 8-6 | .571 | - | | Bob Carpenter Center · Newark, DE |
| 15 | Thu Jan 2 | vsTowson | W81-69 | 9-6 | .600 | - | | TD Arena · Charleston, SC |
| 16 | Sat Jan 4 | vsJMU | W85-69 | 10-6 | .625 | - | | TD Arena · Charleston, SC |
| 17 | Thu Jan 9 | atElon | W73-65 | 11-6 | .647 | - | | Schar Center · Elon, NC |
| 18 | Sat Jan 11 | atWilliam & Mary | L56-67 | 11-7 | .611 | - | | Kaplan Arena · Williamsburg, VA |
| 19 | Thu Jan 16 | vsNortheastern | L76-79 | 11-8 | .579 | - | | TD Arena · Charleston, SC |
| 20 | Sat Jan 18 | vsHofstra | W69-67 | 12-8 | .600 | - | | TD Arena · Charleston, SC |
| 21 | Sat Jan 25 | vsUNC Wilmington | L70-72 | 12-9 | .571 | - | | TD Arena · Charleston, SC |
| 22 | Thu Jan 30 | atJMU | W87-68 | 13-9 | .591 | - | CBSSN | Atlantic Union Bank Center · Harrisonburg, VA |
| 23 | Sat Feb 1 | atTowson | W79-70 | 14-9 | .609 | - | | SECU Arena · Towson, MD |
| 24 | Thu Feb 6 | vsWilliam & Mary | W68-50 | 15-9 | .625 | - | | TD Arena · Charleston, SC |
| 25 | Sat Feb 8 | vsElon | L65-72 | 15-10 | .600 | - | | TD Arena · Charleston, SC |
| 26 | Thu Feb 13 | atHofstra | L63-76 | 15-11 | .577 | - | CBSSN | David S. Mack Sports and Exhibition Complex · Hempstead, NY |
| 27 | Sat Feb 15 | atNortheastern | L51-65 | 15-12 | .556 | - | | Matthews Arena · Boston, MA |
| 28 | Sat Feb 22 | atUNC Wilmington | L55-68 | 15-13 | .536 | - | | Trask Coliseum · Wilmington, NC |
| 29 | Thu Feb 27 | vsDelaware | W80-71 | 16-13 | .552 | - | CBSSN | TD Arena · Charleston, SC |
| 30 | Sat Feb 29 | vsDrexel | W75-66 | 17-13 | .567 | - | | TD Arena · Charleston, SC |
| 31 | Sun Mar 8 | vsDelaware | L67-79 | 17-14 | .548 | - | | TD Arena · Charleston, SC |
