| 1 | Mon Nov 7 | vs Chattanooga | W85-78 | 1-0 | 1.000 | - | | TD Arena · Charleston, SC |
| 2 | Fri Nov 11 | at#1UNC | L86-102 | 1-1 | .500 | - | | Dean E. Smith Center · Chapel Hill, NC |
| 3 | Mon Nov 14 | vsRichmond | W92-90 (OT) | 2-1 | .667 | - | | TD Arena · Charleston, SC |
| 4 | Thu Nov 17 | vsDavidson | W89-66 | 3-1 | .750 | - | ESPNU | TD Arena · Charleston, SC |
| 5 | Fri Nov 18 | vsColorado St | W74-64 | 4-1 | .800 | - | ESPN2 | TD Arena · Charleston, SC |
| 6 | Sun Nov 20 | vsVirginia Tech | W77-75 | 5-1 | .833 | - | ESPN2 | TD Arena · Charleston, SC |
| 7 | Wed Nov 23 | vsKent State | W74-72 | 6-1 | .857 | - | | TD Arena · Charleston, SC |
| 8 | Tue Nov 29 | vsOld Dominion | W75-60 | 7-1 | .875 | - | | TD Arena · Charleston, SC |
| 9 | Sat Dec 3 | atThe Citadel | W79-57 | 8-1 | .889 | - | | McAlister Field House · Charleston, SC |
| 10 | Tue Dec 6 | atPresbyterian | W67-62 | 9-1 | .900 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 11 | Sun Dec 11 | vsTBD | W96-67 | 10-1 | .909 | - | | TD Arena · Charleston, SC |
| 12 | Wed Dec 14 | vsStetson | W65-60 | 11-1 | .917 | - | | TD Arena · Charleston, SC |
| 13 | Mon Dec 19 | atCoast Car | W83-69 | 12-1 | .923 | - | | The HTC Center · Conway, SC |
| 14 | Thu Dec 29 | vsHampton | W89-61 | 13-1 | .929 | - | | TD Arena · Charleston, SC |
| 15 | Sat Dec 31 | atTowson | W76-74 (OT) | 14-1 | .933 | - | | SECU Arena · Towson, MD |
| 16 | Wed Jan 4 | atNC A&T | W92-79 | 15-1 | .938 | #23 | CBS | Corbett Sports Center · Greensboro, NC |
| 17 | Sat Jan 7 | vsDelaware | W75-64 | 16-1 | .941 | #23 | CBS | TD Arena · Charleston, SC |
| 18 | Wed Jan 11 | atUNC Wilmington | W71-69 | 17-1 | .944 | #22 | | Trask Coliseum · Wilmington, NC |
| 19 | Sat Jan 14 | vsElon | W78-60 | 18-1 | .947 | #22 | | TD Arena · Charleston, SC |
| 20 | Mon Jan 16 | vsWilliam & Mary | W82-54 | 19-1 | .950 | #18 | | TD Arena · Charleston, SC |
| 21 | Thu Jan 19 | atMonmouth | W69-55 | 20-1 | .952 | #18 | | OceanFirst Bank Center · West Long Branch, NJ |
| 22 | Sat Jan 21 | atNortheastern | W87-61 | 21-1 | .955 | #18 | | Matthews Arena · Boston, MA |
| 23 | Sat Jan 28 | vsHofstra | L81-85 | 21-2 | .913 | #18 | | TD Arena · Charleston, SC |
| 24 | Thu Feb 2 | atDrexel | L69-70 | 21-3 | .875 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 25 | Sat Feb 4 | atDelaware | W84-67 | 22-3 | .880 | - | | Bob Carpenter Center · Newark, DE |
| 26 | Wed Feb 8 | vsUNC Wilmington | W93-61 | 23-3 | .885 | - | | TD Arena · Charleston, SC |
| 27 | Sat Feb 11 | atHampton | W83-70 | 24-3 | .889 | - | | Convocation Center (VA) · Hampton, VA |
| 28 | Mon Feb 13 | vsNortheastern | W99-63 | 25-3 | .893 | - | | TD Arena · Charleston, SC |
| 29 | Thu Feb 16 | atElon | W88-66 | 26-3 | .897 | - | | Schar Center · Elon, NC |
| 30 | Thu Feb 23 | vsTowson | W83-75 | 27-3 | .900 | - | CBS | TD Arena · Charleston, SC |
| 31 | Sat Feb 25 | vsStony Brook | W92-52 | 28-3 | .903 | - | CBS | TD Arena · Charleston, SC |
| 32 | Sun Mar 5 | vsStony Brook | W74-52 | 29-3 | .906 | - | | TD Arena · Charleston, SC |
| 33 | Mon Mar 6 | vsTowson | W77-72 | 30-3 | .909 | - | CBS | TD Arena · Charleston, SC |
| 34 | Tue Mar 7 | vsUNC Wilmington | W63-58 | 31-3 | .912 | - | CBS | TD Arena · Charleston, SC |
| 35 | Thu Mar 16 | at#5SDSU | L57-63 | 31-4 | .886 | #12 | truTV | Viejas Arena · San Diego, CA |
