| 1 | Mon Nov 3 | vs TBD | TBD | 0-0 | .000 | - | | TD Arena · Charleston, SC |
| 2 | Fri Nov 7 | atLiberty | TBD | 28-7 | .800 | - | | Liberty Arena · Lynchburg, VA |
| 3 | Sat Nov 8 | vsFAU | TBD | 18-16 | .529 | - | | TD Arena · Charleston, SC |
| 4 | Fri Nov 14 | vsSC State | TBD | 20-13 | .606 | - | | TD Arena · Charleston, SC |
| 5 | Mon Nov 17 | vsDrake | TBD | 31-4 | .886 | - | | TD Arena · Charleston, SC |
| 6 | Fri Nov 21 | vsUMass | 3:00 PM | 12-20 | .375 | - | | TD Arena · Charleston, SC |
| 7 | Sun Nov 30 | vsBelmont | TBD | 22-11 | .667 | - | | TD Arena · Charleston, SC |
| 8 | Wed Dec 10 | atSouth Florida | TBD | 13-19 | .406 | - | | Yuengling Center · Tampa, FL |
| 9 | Sun Dec 14 | vsCharlotte | TBD | 11-22 | .333 | - | | TD Arena · Charleston, SC |
| 10 | Wed Dec 17 | vsThe Citadel | 7:00 PM | 5-25 | .167 | - | | TD Arena · Charleston, SC |
| 11 | Sun Dec 21 | atN Kentucky | 12:00 PM | 17-16 | .515 | - | | Truist Arena · Highland Heights, KY |
| 12 | Mon Dec 29 | vsDrexel | TBD | 18-15 | .545 | - | | TD Arena · Charleston, SC |
| 13 | Wed Dec 31 | atElon | TBD | 17-16 | .515 | - | | Schar Center · Elon, NC |
| 14 | Mon Jan 5 | vsWilliam & Mary | 7:00 PM | 17-15 | .531 | - | CBS | TD Arena · Charleston, SC |
| 15 | Sat Jan 10 | vsHampton | TBD | 17-16 | .515 | - | | TD Arena · Charleston, SC |
| 16 | Thu Jan 15 | atTowson | 8:00 PM | 22-11 | .667 | - | CBS | SECU Arena · Towson, MD |
| 17 | Sat Jan 17 | atStony Brook | TBD | 8-24 | .250 | - | | Island FCU Arena · Stony Brook, NY |
| 18 | Thu Jan 22 | vsCampbell | TBD | 15-17 | .469 | - | | TD Arena · Charleston, SC |
| 19 | Sat Jan 24 | vsElon | TBD | 17-16 | .515 | - | | TD Arena · Charleston, SC |
| 20 | Thu Jan 29 | atHofstra | 7:00 PM | 15-18 | .455 | - | | David S. Mack Sports and Exhibition Complex · Hempstead, NY |
| 21 | Sat Jan 31 | atNortheastern | TBD | 17-15 | .531 | - | | Matthews Arena · Boston, MA |
| 22 | Thu Feb 5 | vsNC A&T | TBD | 7-25 | .219 | - | | TD Arena · Charleston, SC |
| 23 | Mon Feb 9 | vsUNC Wilmington | 8:00 PM | 27-8 | .771 | - | CBS | TD Arena · Charleston, SC |
| 24 | Thu Feb 12 | vsHofstra | TBD | 15-18 | .455 | - | | TD Arena · Charleston, SC |
| 25 | Sun Feb 15 | atCampbell | 5:00 PM | 15-17 | .469 | - | CBS | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 26 | Thu Feb 19 | atNC A&T | TBD | 7-25 | .219 | - | | Corbett Sports Center · Greensboro, NC |
| 27 | Sat Feb 21 | vsMonmouth | 4:00 PM | 13-20 | .394 | - | CBS | TD Arena · Charleston, SC |
| 28 | Thu Feb 26 | atHampton | 11:00 AM | 17-16 | .515 | - | | Convocation Center (VA) · Hampton, VA |
| 29 | Sun Mar 1 | atUNC Wilmington | 7:00 PM | 27-8 | .771 | - | CBS | Trask Coliseum · Wilmington, NC |
