| 1 | Mon Nov 6 | vs Iona | W71-69 | 1-0 | 1.000 | - | | TD Arena · Charleston, SC |
| 2 | Fri Nov 10 | atDuquesne | L72-90 | 1-1 | .500 | - | CBS | Alumni Hall (Navy) · Annapolis, MD |
| 3 | Thu Nov 16 | atVermont | L64-73 | 1-2 | .333 | - | ESPNU | The HTC Center · Conway, SC |
| 4 | Fri Nov 17 | atWyoming | L60-67 | 1-3 | .250 | - | ESPNU | The HTC Center · Conway, SC |
| 5 | Sun Nov 19 | atCoast Car | W80-72 | 2-3 | .400 | - | | The HTC Center · Conway, SC |
| 6 | Sun Nov 26 | atKent State | W84-78 | 3-3 | .500 | - | | M.A.C. Center · Kent, OH |
| 7 | Fri Dec 1 | atLiberty | W76-67 | 4-3 | .571 | - | | FAU Arena · Boca Raton, FL |
| 8 | Sat Dec 2 | at#13FAU | L74-90 | 4-4 | .500 | - | ESPNU | FAU Arena · Boca Raton, FL |
| 9 | Sun Dec 10 | vsRhode Island | W85-70 | 5-4 | .556 | - | | TD Arena · Charleston, SC |
| 10 | Thu Dec 14 | vsThe Citadel | W86-71 | 6-4 | .600 | - | | TD Arena · Charleston, SC |
| 11 | Mon Dec 18 | vsCoast Car | W84-81 | 7-4 | .636 | - | | TD Arena · Charleston, SC |
| 12 | Thu Dec 21 | vsSaint Joseph's | W89-82 | 8-4 | .667 | - | | TD Arena · Charleston, SC |
| 13 | Fri Dec 29 | vsTBD | W96-59 | 9-4 | .692 | - | | TD Arena · Charleston, SC |
| 14 | Thu Jan 4 | atHofstra | W73-61 | 10-4 | .714 | - | | David S. Mack Sports and Exhibition Complex · Hempstead, NY |
| 15 | Sat Jan 6 | atStony Brook | W93-87 | 11-4 | .733 | - | | Island FCU Arena · Stony Brook, NY |
| 16 | Thu Jan 11 | vsElon | W80-62 | 12-4 | .750 | - | | TD Arena · Charleston, SC |
| 17 | Sat Jan 13 | vsMonmouth | W94-83 | 13-4 | .765 | - | | TD Arena · Charleston, SC |
| 18 | Thu Jan 18 | vsTowson | L78-82 | 13-5 | .722 | - | | TD Arena · Charleston, SC |
| 19 | Sat Jan 20 | atUNC Wilmington | L69-78 | 13-6 | .684 | - | CBS | Trask Coliseum · Wilmington, NC |
| 20 | Thu Jan 25 | atHampton | W107-86 | 14-6 | .700 | - | | Convocation Center (VA) · Hampton, VA |
| 21 | Sat Jan 27 | atCampbell | W90-67 | 15-6 | .714 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 22 | Thu Feb 1 | vsUNC Wilmington | L74-80 | 15-7 | .682 | - | | TD Arena · Charleston, SC |
| 23 | Sat Feb 3 | atWilliam & Mary | W84-83 | 16-7 | .696 | - | | Kaplan Arena · Williamsburg, VA |
| 24 | Thu Feb 8 | vsNC A&T | W80-58 | 17-7 | .708 | - | CBS | TD Arena · Charleston, SC |
| 25 | Sat Feb 10 | vsDrexel | W80-70 | 18-7 | .720 | - | | TD Arena · Charleston, SC |
| 26 | Thu Feb 15 | atNortheastern | W77-73 | 19-7 | .731 | - | | Matthews Arena · Boston, MA |
| 27 | Mon Feb 19 | vsWilliam & Mary | W65-57 | 20-7 | .741 | - | CBS | TD Arena · Charleston, SC |
| 28 | Thu Feb 22 | atDelaware | W90-71 | 21-7 | .750 | - | | Bob Carpenter Center · Newark, DE |
| 29 | Sat Feb 24 | atTowson | W72-56 | 22-7 | .759 | - | CBS | SECU Arena · Towson, MD |
| 30 | Thu Feb 29 | vsCampbell | W96-73 | 23-7 | .767 | - | | TD Arena · Charleston, SC |
| 31 | Sat Mar 2 | vsHofstra | W87-76 | 24-7 | .774 | - | | TD Arena · Charleston, SC |
| 32 | Sun Mar 10 | vsMonmouth | W83-59 | 25-7 | .781 | - | | TD Arena · Charleston, SC |
| 33 | Mon Mar 11 | vsTowson | W61-56 | 26-7 | .788 | - | CBS | TD Arena · Charleston, SC |
| 34 | Tue Mar 12 | vsStony Brook | W82-79 (OT) | 27-7 | .794 | - | CBS | TD Arena · Charleston, SC |
| 35 | Fri Mar 22 | at#4Alabama | L96-109 | 27-8 | .771 | #13 | truTV | Coleman Coliseum · Tuscaloosa, AL |
