| 1 | Mon Nov 4 | at S Illinois | W90-80 | 1-0 | 1.000 | - | | Banterra Center · Carbondale, IL |
| 2 | Fri Nov 8 | vsSouth Florida | W86-71 | 2-0 | 1.000 | - | FloSports | TD Arena · Charleston, SC |
| 3 | Fri Nov 15 | vsFAU | W119-116 (2OT) | 3-0 | 1.000 | - | | TD Arena · Charleston, SC |
| 4 | Sun Nov 17 | vsLiberty | L47-68 | 3-1 | .750 | - | | TD Arena · Charleston, SC |
| 5 | Wed Nov 20 | atThe Citadel | W76-61 | 4-1 | .800 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 6 | Sun Nov 24 | atRhode Island | L53-91 | 4-2 | .667 | - | ESPN+ | Ryan Center · Kingston, RI |
| 7 | Wed Nov 27 | vsN Kentucky | W79-64 | 5-2 | .714 | - | | TD Arena · Charleston, SC |
| 8 | Tue Dec 3 | vsTBD | W94-71 | 6-2 | .750 | - | | TD Arena · Charleston, SC |
| 9 | Tue Dec 10 | atSaint Joseph's | W78-75 | 7-2 | .778 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 10 | Mon Dec 16 | vsWofford | W77-67 | 8-2 | .800 | - | | TD Arena · Charleston, SC |
| 11 | Sun Dec 22 | vsOregon St | L65-74 | 8-3 | .727 | - | ESPN2 | Stan Sheriff Center · Honolulu, HI |
| 12 | Mon Dec 23 | atLoyola Chicago | W77-68 | 9-3 | .750 | - | ESPNU | Stan Sheriff Center · Honolulu, HI |
| 13 | Wed Dec 25 | atCharlotte | W84-81 | 10-3 | .769 | - | ESPNU | Stan Sheriff Center · Honolulu, HI |
| 14 | Thu Jan 2 | vsHampton | W94-67 | 11-3 | .786 | - | | TD Arena · Charleston, SC |
| 15 | Sat Jan 4 | vsTowson | W77-69 | 12-3 | .800 | - | | TD Arena · Charleston, SC |
| 16 | Thu Jan 9 | atHofstra | W67-61 | 13-3 | .813 | - | | David S. Mack Sports and Exhibition Complex · Hempstead, NY |
| 17 | Sat Jan 11 | atMonmouth | L73-84 | 13-4 | .765 | - | | OceanFirst Bank Center · West Long Branch, NJ |
| 18 | Thu Jan 16 | atCampbell | W67-61 | 14-4 | .778 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 19 | Sat Jan 18 | vsNortheastern | W87-85 | 15-4 | .789 | - | | TD Arena · Charleston, SC |
| 20 | Thu Jan 23 | vsUNC Wilmington | L83-85 | 15-5 | .750 | - | | TD Arena · Charleston, SC |
| 21 | Sat Jan 25 | atElon | W76-62 | 16-5 | .762 | - | | Schar Center · Elon, NC |
| 22 | Thu Jan 30 | vsStony Brook | W81-74 | 17-5 | .773 | - | CBSSN | TD Arena · Charleston, SC |
| 23 | Mon Feb 3 | atWilliam & Mary | L75-90 | 17-6 | .739 | - | CBSSN | Kaplan Arena · Williamsburg, VA |
| 24 | Thu Feb 6 | vsNC A&T | W66-63 | 18-6 | .750 | - | CBSSN | TD Arena · Charleston, SC |
| 25 | Sat Feb 8 | vsElon | W88-83 (OT) | 19-6 | .760 | - | | TD Arena · Charleston, SC |
| 26 | Thu Feb 13 | atUNC Wilmington | L66-86 | 19-7 | .731 | - | CBSSN | Trask Coliseum · Wilmington, NC |
| 27 | Sat Feb 15 | atNC A&T | W69-59 | 20-7 | .741 | - | | Corbett Sports Center · Greensboro, NC |
| 28 | Thu Feb 20 | atNortheastern | W73-62 | 21-7 | .750 | - | | Matthews Arena · Boston, MA |
| 29 | Sat Feb 22 | atDrexel | L55-64 | 21-8 | .724 | - | CBSSN | Daskalakis Athletic Center · Philadelphia, PA |
| 30 | Thu Feb 27 | vsDelaware | W94-84 | 22-8 | .733 | - | | TD Arena · Charleston, SC |
| 31 | Sat Mar 1 | vsCampbell | W87-65 | 23-8 | .742 | - | | TD Arena · Charleston, SC |
| 32 | Sun Mar 9 | vsMonmouth | W79-78 (OT) | 24-8 | .750 | - | | TD Arena · Charleston, SC |
| 33 | Mon Mar 10 | atUNC Wilmington | L67-68 | 24-9 | .727 | - | CBSSN | Trask Coliseum · Wilmington, NC |
