| 1 | Mon Nov 3 | vs Niagara | 7:00 PM | 11-20 | .355 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 2 | Fri Nov 7 | vsSacred Heart | 7:00 PM | 15-18 | .455 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 3 | Tue Nov 11 | vsQueens | 8:00 PM | 20-15 | .571 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 4 | Sat Nov 15 | atVillanova | TBD | 21-15 | .583 | - | | Finneran Pavilion · Villanova, PA |
| 5 | Wed Nov 19 | vsLoyola MD | 7:00 PM | 12-19 | .387 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 6 | Sat Nov 22 | atNortheastern | TBD | 17-15 | .531 | - | | Matthews Arena · Boston, MA |
| 7 | Wed Nov 26 | vsTBD | 7:00 PM | 0-0 | .000 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 8 | Tue Dec 2 | vsWilliam & Mary | 7:00 PM | 17-15 | .531 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 9 | Sat Dec 6 | vsStony Brook | 2:00 PM | 8-24 | .250 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 10 | Wed Dec 10 | atBoise St | TBD | 26-11 | .703 | - | | ExtraMile Arena · Boise, ID |
| 11 | Sat Dec 13 | atNevada | TBD | 17-16 | .515 | - | | Lawlor Events Center · Reno, NV |
| 12 | Mon Dec 22 | vsCanisius | 7:00 PM | 3-28 | .097 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 13 | Sat Dec 27 | vsTBD | 2:00 PM | 0-0 | .000 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 14 | Tue Dec 30 | atDavidson | TBD | 17-16 | .515 | - | | John M. Belk Arena · Davidson, NC |
| 15 | Sat Jan 3 | vsVCU | TBD | 28-7 | .800 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 16 | Wed Jan 7 | atSaint Joseph's | 7:00 PM | 22-13 | .629 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 17 | Tue Jan 13 | vsDayton | TBD | 23-11 | .676 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 18 | Sat Jan 17 | atFordham | 12:30 PM | 12-21 | .364 | - | | Rose Hill Gymnasium · Bronx, NY |
| 19 | Tue Jan 20 | vsSaint Louis | TBD | 19-15 | .559 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 20 | Sat Jan 24 | atLoyola Chicago | TBD | 25-12 | .676 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 21 | Wed Jan 28 | vsSt Bonaventure | TBD | 22-12 | .647 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 22 | Sun Feb 1 | vsRhode Island | TBD | 18-13 | .581 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 23 | Wed Feb 4 | atGeorge Mason | 7:00 PM | 27-9 | .750 | - | | EagleBank Arena · Fairfax, VA |
| 24 | Sat Feb 7 | vsG Washington | 2:00 PM | 21-13 | .618 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 25 | Sat Feb 14 | atSt Bonaventure | TBD | 22-12 | .647 | - | | Reilly Center · Saint Bonaventure, NY |
| 26 | Wed Feb 18 | vsLa Salle | 7:00 PM | 14-19 | .424 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 27 | Sat Feb 21 | atDayton | TBD | 23-11 | .676 | - | | UD Arena · Dayton, OH |
| 28 | Wed Feb 25 | vsDavidson | TBD | 17-16 | .515 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 29 | Sat Feb 28 | atSaint Louis | TBD | 19-15 | .559 | - | | Chaifetz Arena · St. Louis, MO |
| 30 | Wed Mar 4 | atRhode Island | TBD | 18-13 | .581 | - | | Ryan Center · Kingston, RI |
| 31 | Sat Mar 7 | vsRichmond | TBD | 10-22 | .313 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
