| 1 | Tue Nov 5 | vs Princeton | W94-67 | 1-0 | 1.000 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 2 | Tue Nov 12 | vsLamar | W66-56 | 2-0 | 1.000 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 3 | Fri Nov 15 | vsLipscomb | W58-36 | 3-0 | 1.000 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 4 | Thu Nov 21 | atIndiana St | W74-71 | 4-0 | 1.000 | - | | Hulman Center · Terre Haute, IN |
| 5 | Fri Nov 22 | atAir Force | W69-63 | 5-0 | 1.000 | - | | Clune Arena · Colorado Springs, CO |
| 6 | Sun Nov 24 | vsLMU | W71-50 | 6-0 | 1.000 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 7 | Wed Dec 4 | vsVMI | W71-58 | 7-0 | 1.000 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 8 | Mon Dec 9 | vsColumbia | W90-54 | 8-0 | 1.000 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 9 | Sat Dec 14 | vsRadford | W71-49 | 9-0 | 1.000 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 10 | Sat Dec 21 | atAustin Peay | W86-77 | 10-0 | 1.000 | - | | Winfield Dunn Center · Clarksville, TN |
| 11 | Sun Dec 22 | vsUAB | L68-77 | 10-1 | .909 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 12 | Sun Dec 29 | vsMarshall | L61-83 | 10-2 | .833 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 13 | Thu Jan 2 | vsSaint Louis | W73-59 | 11-2 | .846 | - | | UPMC Events Center · Moon Township, PA |
| 14 | Sun Jan 5 | vsDavidson | W71-64 | 12-2 | .857 | - | NBCSN | UPMC Events Center · Moon Township, PA |
| 15 | Wed Jan 8 | atSaint Joseph's | W78-60 | 13-2 | .867 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 16 | Sat Jan 11 | atG Washington | W66-61 | 14-2 | .875 | - | | Charles E. Smith Center · Washington, D.C. |
| 17 | Wed Jan 15 | vsFordham | W58-56 (OT) | 15-2 | .882 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 18 | Wed Jan 22 | atRhode Island | L55-77 | 15-3 | .833 | - | | Ryan Center · Kingston, RI |
| 19 | Sat Jan 25 | atUMass | L64-73 | 15-4 | .789 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 20 | Wed Jan 29 | vs7Dayton | L69-73 | 15-5 | .750 | - | CBSSN | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 21 | Sun Feb 2 | vsLa Salle | W71-69 | 16-5 | .762 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 22 | Wed Feb 5 | atSaint Louis | W82-68 | 17-5 | .773 | - | | Chaifetz Arena · St. Louis, MO |
| 23 | Sat Feb 8 | vsSt Bonaventure | L80-83 | 17-6 | .739 | - | NBCSN | UPMC Events Center · Moon Township, PA |
| 24 | Sun Feb 16 | atFordham | W59-54 | 18-6 | .750 | - | | Rose Hill Gymnasium · Bronx, NY |
| 25 | Wed Feb 19 | vsG Washington | L67-70 | 18-7 | .720 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 26 | Sat Feb 22 | at5Dayton | L70-80 | 18-8 | .692 | - | | UD Arena · Dayton, OH |
| 27 | Wed Feb 26 | atSt Bonaventure | W81-77 (OT) | 19-8 | .704 | - | | Reilly Center · Saint Bonaventure, NY |
| 28 | Sat Feb 29 | vsGeorge Mason | W81-78 | 20-8 | .714 | - | | UPMC Events Center · Moon Township, PA |
| 29 | Tue Mar 3 | atVCU | W80-77 (OT) | 21-8 | .724 | - | | Stuart C. Siegel Center · Richmond, VA |
| 30 | Fri Mar 6 | vsRichmond | L62-73 | 21-9 | .700 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
