| 1 | Tue Nov 9 | vs Rider | W73-61 | 1-0 | 1.000 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 2 | Sat Nov 13 | vsHofstra | L63-73 | 1-1 | .500 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 3 | Mon Nov 15 | vsWeber St | L59-63 | 1-2 | .333 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 4 | Fri Nov 19 | vsNortheastern | L55-71 | 1-3 | .250 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 5 | Sat Nov 20 | atColorado | L76-84 (OT) | 1-4 | .200 | - | | CU Events Center · Boulder, CO |
| 6 | Mon Nov 22 | vsBradley | W78-70 | 2-4 | .333 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 7 | Sun Nov 28 | vsAmerican | W88-79 | 3-4 | .429 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 8 | Wed Dec 1 | vsBowling Green | L70-78 | 3-5 | .375 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 9 | Sat Dec 4 | atMarshall | L71-72 | 3-6 | .333 | - | | Cam Henderson Center · Huntington, WV |
| 10 | Tue Dec 7 | atDePaul | L67-87 | 3-7 | .300 | - | FS1 | Wintrust Arena · Chicago, IL |
| 11 | Sat Dec 11 | vsNew Hampshire | W64-62 | 4-7 | .364 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 12 | Sun Dec 19 | vsUC Irvine | W76-54 | 5-7 | .417 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 14 | Thu Dec 30 | atDavidson | PPD | 6-24 | .200 | - | | John M. Belk Arena · Davidson, NC |
| 16 | Wed Jan 5 | vsG Washington | PPD | 6-24 | .200 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 17 | Sat Jan 8 | atUMass | W78-74 | 6-7 | .462 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 18 | Wed Jan 12 | atFordham | L71-72 | 6-8 | .429 | - | | Rose Hill Gymnasium · Bronx, NY |
| 19 | Sat Jan 15 | vsDayton | L52-72 | 6-9 | .400 | - | USA Net | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 20 | Fri Jan 21 | vsSt Bonaventure | L56-64 | 6-10 | .375 | - | ESPN2 | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 21 | Wed Jan 26 | atSaint Joseph's | L61-72 | 6-11 | .353 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 22 | Sat Jan 29 | vsSaint Louis | L53-77 | 6-12 | .333 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 23 | Tue Feb 1 | vsRichmond | L57-74 | 6-13 | .316 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 24 | Sat Feb 5 | atVCU | L62-71 | 6-14 | .300 | - | | Stuart C. Siegel Center · Richmond, VA |
| 25 | Wed Feb 9 | atDayton | L54-75 | 6-15 | .286 | - | | UD Arena · Dayton, OH |
| 26 | Sat Feb 12 | vsFordham | L54-65 | 6-16 | .273 | - | CBS | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 27 | Mon Feb 14 | atDavidson | L61-72 | 6-17 | .261 | - | | John M. Belk Arena · Davidson, NC |
| 28 | Wed Feb 16 | vsG Washington | L52-73 | 6-18 | .250 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 29 | Sat Feb 19 | atSt Bonaventure | L55-81 | 6-19 | .240 | - | ESPNU | Reilly Center · Saint Bonaventure, NY |
| 30 | Wed Feb 23 | vsDavidson | L50-74 | 6-20 | .231 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 31 | Sat Feb 26 | atRhode Island | L54-70 | 6-21 | .222 | - | USA Net | Ryan Center · Kingston, RI |
| 32 | Wed Mar 2 | atG Washington | L93-98 (3OT) | 6-22 | .214 | - | | Charles E. Smith Center · Washington, D.C. |
| 33 | Sat Mar 5 | vsLa Salle | L76-85 | 6-23 | .207 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 34 | Wed Mar 9 | atRhode Island | L77-79 | 6-24 | .200 | - | | Ryan Center · Kingston, RI |
