| 1 | Tue Nov 8 | vs Montana | W91-63 | 1-0 | 1.000 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 2 | Fri Nov 11 | at #4Kentucky | L52-77 | 1-1 | .500 | - | SEC Network | Rupp Arena · Lexington, KY |
| 3 | Mon Nov 14 | vs SC State | W96-71 | 2-1 | .667 | - | CBS | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 4 | Fri Nov 18 | vs Colgate | W85-80 | 3-1 | .750 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 5 | Mon Nov 21 | vs North Florida | W83-82 | 4-1 | .800 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 6 | Wed Nov 23 | vs Alabama St | W75-57 | 5-1 | .833 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 7 | Tue Nov 29 | vs UCSB | W72-61 | 6-1 | .857 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 8 | Sat Dec 3 | vs Ball State | W78-77 | 7-1 | .875 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 9 | Thu Dec 8 | vs Marshall | L71-82 | 7-2 | .778 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 10 | Sun Dec 11 | vs New Mexico St | L60-73 | 7-3 | .700 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 11 | Wed Dec 14 | vs DePaul | W66-55 | 8-3 | .727 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 12 | Sat Dec 17 | vs Indiana St | W92-86 | 9-3 | .750 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 13 | Wed Dec 21 | vs Winthrop | W74-57 | 10-3 | .769 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 14 | Wed Dec 28 | at Dayton | L57-69 | 10-4 | .714 | - | | UD Arena · Dayton, OH |
| 15 | Sat Dec 31 | vs Rhode Island | W72-61 | 11-4 | .733 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 16 | Wed Jan 4 | vs VCU | W79-70 | 12-4 | .750 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 17 | Sat Jan 7 | at Richmond | L73-75 | 12-5 | .706 | - | | Robins Center · Richmond, VA |
| 18 | Wed Jan 11 | at Saint Joseph's | W92-80 | 13-5 | .722 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 19 | Wed Jan 18 | at St Bonaventure | L56-65 | 13-6 | .684 | - | | Reilly Center · Saint Bonaventure, NY |
| 20 | Sat Jan 21 | vs Fordham | L58-65 | 13-7 | .650 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 21 | Wed Jan 25 | vs Loyola Chicago | W72-58 | 14-7 | .667 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 22 | Sat Jan 28 | at UMass | L79-87 | 14-8 | .636 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 23 | Sat Feb 4 | at G Washington | W93-67 | 15-8 | .652 | - | | Charles E. Smith Center · Washington, D.C. |
| 24 | Wed Feb 8 | vs George Mason | W75-52 | 16-8 | .667 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 25 | Sat Feb 11 | vsSt Bonaventure | W56-54 | 17-8 | .680 | - | USA Net | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 26 | Wed Feb 15 | vsSaint Joseph's | W76-62 | 18-8 | .692 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 27 | Sat Feb 18 | at Saint Louis | L85-90 | 18-9 | .667 | - | | Chaifetz Arena · St. Louis, MO |
| 28 | Wed Feb 22 | at La Salle | W91-74 | 19-9 | .679 | - | | Tom Gola Arena · Philadelphia, PA |
| 29 | Sun Feb 26 | vs Davidson | L67-71 | 19-10 | .655 | - | USA Net | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 30 | Wed Mar 1 | vsUMass | W88-79 | 20-10 | .667 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 31 | Sat Mar 4 | atFordham | L60-87 | 20-11 | .645 | - | | Rose Hill Gymnasium · Bronx, NY |
| 32 | Wed Mar 8 | vsLa Salle | L70-81 | 20-12 | .625 | - | USA Net | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 33 | Sun Mar 19 | at Rice | L78-84 | 20-13 | .606 | - | | Tudor Fieldhouse · Houston, TX |
