| 1 | Mon Nov 30 | vs Little Rock | L66-76 | 0-1 | .000 | - | | KFC Yum! Center · Louisville, KY |
| 2 | Wed Dec 2 | vsUNC Greensboro | W81-68 | 1-1 | .500 | - | | KFC Yum! Center · Louisville, KY |
| 4 | Sat Dec 19 | atRichmond | PPD | 9-9 | .500 | - | | Robins Center · Richmond, VA |
| 6 | Sat Jan 2 | atG Washington | W75-63 | 2-1 | .667 | - | NBCSN | Charles E. Smith Center · Washington, D.C. |
| 7 | Sun Jan 3 | atG Washington | L73-75 | 2-2 | .500 | - | | Charles E. Smith Center · Washington, D.C. |
| 8 | Tue Jan 5 | vsDavidson | L48-61 | 2-3 | .400 | - | CBSSN | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 9 | Sat Jan 9 | vsFordham | W48-45 | 3-3 | .500 | - | NBCSN | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 10 | Wed Jan 13 | atDayton | L63-72 | 3-4 | .429 | - | CBSSN | UD Arena · Dayton, OH |
| 11 | Fri Jan 15 | atSt Bonaventure | L48-62 | 3-5 | .375 | - | ESPN2 | Reilly Center · Saint Bonaventure, NY |
| 12 | Wed Jan 20 | vsRhode Island | W71-69 | 4-5 | .444 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 13 | Sat Jan 23 | vsSt Bonaventure | L61-65 | 4-6 | .400 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 14 | Wed Jan 27 | atFordham | W86-62 | 5-6 | .455 | - | | Rose Hill Gymnasium · Bronx, NY |
| 15 | Sat Jan 30 | vsSaint Joseph's | W67-50 | 6-6 | .500 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 16 | Tue Feb 2 | vsDayton | W69-64 | 7-6 | .538 | - | ESPN2 | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 19 | Sat Feb 20 | atRichmond | L72-79 | 7-7 | .500 | - | | Robins Center · Richmond, VA |
| 20 | Wed Feb 24 | atLa Salle | L65-85 | 7-8 | .467 | - | | Tom Gola Arena · Philadelphia, PA |
| 21 | Sat Feb 27 | vsRhode Island | W86-75 | 8-8 | .500 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 22 | Thu Mar 4 | atRichmond | W67-62 | 9-8 | .529 | - | NBCSN | Stuart C. Siegel Center · Richmond, VA |
| 23 | Fri Mar 5 | atSt Bonaventure | L59-75 | 9-9 | .500 | - | NBCSN | Stuart C. Siegel Center · Richmond, VA |
