| 1 | Wed Nov 6 | vs Incarnate Word | W82-42 | 1-0 | 1.000 | - | | Mizzou Arena · Columbia, MO |
| 2 | Fri Nov 8 | vsN Kentucky | W71-56 | 2-0 | 1.000 | - | | Mizzou Arena · Columbia, MO |
| 3 | Tue Nov 12 | at21Xavier | L58-63 (OT) | 2-1 | .667 | - | CBSSN | Cintas Center · Cincinnati, OH |
| 4 | Mon Nov 18 | vsWofford | W75-56 | 3-1 | .750 | - | | Mizzou Arena · Columbia, MO |
| 5 | Wed Nov 20 | vsMorehead St | W70-52 | 4-1 | .800 | - | | Mizzou Arena · Columbia, MO |
| 6 | Mon Nov 25 | vsButler | L52-63 | 4-2 | .667 | - | ESPNU | T-Mobile Center · Kansas City, MOS |
| 7 | Tue Nov 26 | vsOklahoma | L66-77 | 4-3 | .571 | - | ESPNEWS | T-Mobile Center · Kansas City, MOS |
| 8 | Tue Dec 3 | vsCharleston So | L60-68 | 4-4 | .500 | - | | Mizzou Arena · Columbia, MO |
| 9 | Sat Dec 7 | atTemple | W64-54 | 5-4 | .556 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 10 | Sun Dec 15 | vsS Illinois | W64-48 | 6-4 | .600 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 11 | Sat Dec 21 | vsIllinois | W63-56 | 7-4 | .636 | - | SEC Network | Enterprise Center · St. Louis, MO |
| 12 | Mon Dec 30 | vsChicago St | W91-33 | 8-4 | .667 | - | | Mizzou Arena · Columbia, MO |
| 13 | Sat Jan 4 | at17Kentucky | L59-71 | 8-5 | .615 | - | SEC Network | Rupp Arena · Lexington, KY |
| 14 | Tue Jan 7 | vsTennessee | L59-69 | 8-6 | .571 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 15 | Sat Jan 11 | vsFlorida | W91-75 | 9-6 | .600 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 16 | Tue Jan 14 | atMississippi St | L45-72 | 9-7 | .563 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 17 | Sat Jan 18 | atAlabama | L74-88 | 9-8 | .529 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 18 | Tue Jan 21 | vsTexas A&M | L64-66 | 9-9 | .500 | - | ESPNU | Mizzou Arena · Columbia, MO |
| 19 | Sat Jan 25 | atWest Virginia | L51-74 | 9-10 | .474 | - | ESPN | WVU Coliseum · Morgantown, WV |
| 20 | Tue Jan 28 | vsGeorgia | W72-69 | 10-10 | .500 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 21 | Sat Feb 1 | atSouth Carolina | L54-76 | 10-11 | .476 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 22 | Tue Feb 4 | atTexas A&M | L51-68 | 10-12 | .455 | - | SEC Network | Reed Arena · College Station, TX |
| 23 | Sat Feb 8 | vsArkansas | W83-79 (OT) | 11-12 | .478 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 24 | Tue Feb 11 | at25LSU | L78-82 | 11-13 | .458 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 25 | Sat Feb 15 | vs11Auburn | W85-73 | 12-13 | .480 | - | ESPN2 | Mizzou Arena · Columbia, MO |
| 26 | Tue Feb 18 | vsOle Miss | W71-68 | 13-13 | .500 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 27 | Sat Feb 22 | atArkansas | L68-78 | 13-14 | .481 | - | SEC Network | Bud Walton Arena · Fayetteville, AR |
| 28 | Wed Feb 26 | atVanderbilt | W61-52 | 14-14 | .500 | - | ESPNU | Memorial Gymnasium (TN) · Nashville, TN |
| 29 | Sat Feb 29 | vsMississippi St | L63-67 | 14-15 | .483 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 30 | Wed Mar 4 | atOle Miss | L67-75 | 14-16 | .467 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 31 | Sat Mar 7 | vsAlabama | W69-50 | 15-16 | .484 | - | SEC Network | Mizzou Arena · Columbia, MO |
