| 1 | Tue Nov 9 | vs Fullerton | W84-77 | 1-0 | 1.000 | - | | Leavey Center · Santa Clara, CA |
| 2 | Fri Nov 12 | vsStanford | W88-72 | 2-0 | 1.000 | - | CBS | Leavey Center · Santa Clara, CA |
| 3 | Tue Nov 16 | vsNevada | W96-74 | 3-0 | 1.000 | - | | Leavey Center · Santa Clara, CA |
| 4 | Fri Nov 19 | vsCal Poly | W87-57 | 4-0 | 1.000 | - | | Leavey Center · Santa Clara, CA |
| 5 | Mon Nov 22 | atTCU | W85-66 | 5-0 | 1.000 | - | CBS | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 6 | Thu Nov 25 | vsFresno St | L52-59 | 5-1 | .833 | - | CBS | Leavey Center · Santa Clara, CA |
| 7 | Sat Nov 27 | vsUC Irvine | L64-69 | 5-2 | .714 | - | | Leavey Center · Santa Clara, CA |
| 8 | Tue Nov 30 | vsHawai'i | W70-58 | 6-2 | .750 | - | | Leavey Center · Santa Clara, CA |
| 9 | Sat Dec 4 | vsLouisiana Tech | L75-78 | 6-3 | .667 | - | | Leavey Center · Santa Clara, CA |
| 10 | Tue Dec 7 | vsMount St Mary | W88-77 | 7-3 | .700 | - | | Leavey Center · Santa Clara, CA |
| 11 | Sat Dec 11 | atCalifornia | L60-72 | 7-4 | .636 | - | PACN | Haas Pavilion · Berkeley, CA |
| 12 | Tue Dec 14 | atBoise St | L60-72 | 7-5 | .583 | - | CBS | ExtraMile Arena · Boise, ID |
| 13 | Fri Dec 17 | vsFAMU | W80-66 | 8-5 | .615 | - | | Leavey Center · Santa Clara, CA |
| 14 | Sun Dec 19 | vsMontana | W79-64 | 9-5 | .643 | - | | Leavey Center · Santa Clara, CA |
| 15 | Tue Dec 21 | atSan Jose St | W79-57 | 10-5 | .667 | - | | Provident Credit Union Event Center · San Jose, CA |
| 16 | Thu Dec 30 | atPacific | PPD | 21-12 | .636 | - | | Alex G. Spanos Center · Stockton, CA |
| 17 | Sat Jan 1 | vsSan Diego | PPD | 21-12 | .636 | - | | Leavey Center · Santa Clara, CA |
| 18 | Thu Jan 6 | vsSaint Mary's | PPD | 21-12 | .636 | - | | Leavey Center · Santa Clara, CA |
| 19 | Sat Jan 8 | atPacific | PPD | 21-12 | .636 | - | | Alex G. Spanos Center · Stockton, CA |
| 20 | Wed Jan 12 | atPacific | W84-70 | 11-5 | .688 | - | | Alex G. Spanos Center · Stockton, CA |
| 21 | Sat Jan 15 | vs#2Gonzaga | L83-115 | 11-6 | .647 | - | | Leavey Center · Santa Clara, CA |
| 22 | Thu Jan 20 | atSaint Mary's | L65-73 | 11-7 | .611 | - | CBS | University Credit Union Pavilion · Moraga, CA |
| 23 | Mon Jan 24 | vsSan Diego | W78-74 (OT) | 12-7 | .632 | - | | Leavey Center · Santa Clara, CA |
| 24 | Thu Jan 27 | vsBYU | W77-76 | 13-7 | .650 | - | ESPNU | Leavey Center · Santa Clara, CA |
| 25 | Sat Jan 29 | atSan Francisco | L85-88 | 13-8 | .619 | - | | War Memorial at the Sobrato Center · San Francisco, CA |
| 26 | Mon Jan 31 | vsPacific | W81-59 | 14-8 | .636 | - | | Leavey Center · Santa Clara, CA |
| 27 | Thu Feb 3 | vsLMU | W79-60 | 15-8 | .652 | - | | Leavey Center · Santa Clara, CA |
| 28 | Sat Feb 5 | atSan Diego | W79-66 | 16-8 | .667 | - | | Jenny Craig Pavilion · San Diego, CA |
| 29 | Tue Feb 8 | vs#22Saint Mary's | W77-72 | 17-8 | .680 | - | ESPNU | Leavey Center · Santa Clara, CA |
| 30 | Sat Feb 12 | vsSan Francisco | L58-74 | 17-9 | .654 | - | | Leavey Center · Santa Clara, CA |
| 32 | Thu Feb 17 | atLMU | W84-80 | 18-9 | .667 | - | | Gersten Pavilion · Los Angeles, CA |
| 33 | Sat Feb 19 | at#1Gonzaga | L69-81 | 18-10 | .643 | - | | McCarthey Athletic Center · Spokane, WA |
| 34 | Thu Feb 24 | atPepperdine | W89-73 | 19-10 | .655 | - | | Firestone Fieldhouse · Malibu, CA |
| 35 | Sat Feb 26 | vsPortland | W102-89 | 20-10 | .667 | - | | Leavey Center · Santa Clara, CA |
| 36 | Sun Mar 6 | vsPortland | W91-67 | 21-10 | .677 | - | ESPN2 | Leavey Center · Santa Clara, CA |
| 37 | Mon Mar 7 | atSaint Mary's | L72-75 | 21-11 | .656 | - | ESPN2 | University Credit Union Pavilion · Moraga, CA |
| 38 | Tue Mar 15 | atWashington St | L50-63 | 21-12 | .636 | - | ESPNU | Friel Court at Beasley Coliseum · Pullman, WA |
