| 1 | Mon Nov 7 | vs E Washington | W84-72 | 1-0 | 1.000 | - | | Leavey Center · Santa Clara, CA |
| 2 | Thu Nov 10 | vsGeorgia So | W78-62 | 2-0 | 1.000 | - | | Leavey Center · Santa Clara, CA |
| 3 | Mon Nov 14 | atUtah State | L74-96 | 2-1 | .667 | - | | Dee Glen Smith Spectrum · Logan, UT |
| 4 | Fri Nov 18 | atDePaul | W69-61 | 3-1 | .750 | - | CBSSN | Wintrust Arena · Chicago, IL |
| 5 | Sun Nov 20 | atUCF | L50-57 | 3-2 | .600 | - | CBSSN | Addition Financial Arena · Orlando, FL |
| 6 | Wed Nov 23 | vsTBD | W64-51 | 4-2 | .667 | - | | Leavey Center · Santa Clara, CA |
| 7 | Sat Nov 26 | vsIona | W86-76 | 5-2 | .714 | - | | Orleans Arena · Las Vegas, NV |
| 8 | Wed Nov 30 | atWyoming | W89-85 (OT) | 6-2 | .750 | - | | Arena Auditorium · Laramie, WY |
| 9 | Sat Dec 3 | vsSacramento St | W72-65 | 7-2 | .778 | - | | Leavey Center · Santa Clara, CA |
| 10 | Wed Dec 7 | vsNew Mexico St | W66-65 | 8-2 | .800 | - | | Leavey Center · Santa Clara, CA |
| 11 | Sat Dec 10 | vsSan Jose St | L64-75 | 8-3 | .727 | - | | Leavey Center · Santa Clara, CA |
| 12 | Tue Dec 13 | vsPortland St | W78-75 | 9-3 | .750 | - | | Leavey Center · Santa Clara, CA |
| 13 | Thu Dec 15 | vsUC Irvine | W86-74 | 10-3 | .769 | - | | Leavey Center · Santa Clara, CA |
| 14 | Sun Dec 18 | vsCalifornia | W71-62 | 11-3 | .786 | - | | Leavey Center · Santa Clara, CA |
| 15 | Thu Dec 22 | vsBoise St | W73-58 | 12-3 | .800 | - | | Leavey Center · Santa Clara, CA |
| 16 | Thu Dec 29 | vsSan Francisco | W79-67 | 13-3 | .813 | - | | Leavey Center · Santa Clara, CA |
| 17 | Sat Dec 31 | vsSaint Mary's | L64-67 | 13-4 | .765 | - | | Leavey Center · Santa Clara, CA |
| 18 | Thu Jan 5 | atPepperdine | W89-79 | 14-4 | .778 | - | | Firestone Fieldhouse · Malibu, CA |
| 19 | Sat Jan 7 | vs9Gonzaga | L76-81 | 14-5 | .737 | - | | Leavey Center · Santa Clara, CA |
| 20 | Sat Jan 14 | atPacific | W92-81 | 15-5 | .750 | - | | Alex G. Spanos Center · Stockton, CA |
| 21 | Thu Jan 19 | vsBYU | W83-76 | 16-5 | .762 | - | CBSSN | Leavey Center · Santa Clara, CA |
| 22 | Sat Jan 21 | atSaint Mary's | L58-77 | 16-6 | .727 | - | | University Credit Union Pavilion · Moraga, CA |
| 23 | Sat Jan 28 | vsPacific | L89-95 | 16-7 | .696 | - | | Leavey Center · Santa Clara, CA |
| 24 | Thu Feb 2 | at12Gonzaga | L70-88 | 16-8 | .667 | - | CBSSN | McCarthey Athletic Center · Spokane, WA |
| 25 | Sat Feb 4 | atSan Francisco | W84-70 | 17-8 | .680 | - | ESPNU | War Memorial at the Sobrato Center · San Francisco, CA |
| 26 | Thu Feb 9 | vsSan Diego | W80-75 | 18-8 | .692 | - | | Leavey Center · Santa Clara, CA |
| 27 | Sat Feb 11 | vsLMU | W71-69 | 19-8 | .704 | - | | Leavey Center · Santa Clara, CA |
| 28 | Thu Feb 16 | atBYU | W81-74 | 20-8 | .714 | - | CBSSN | Marriott Center · Provo, UT |
| 29 | Sat Feb 18 | atPortland | W103-84 | 21-8 | .724 | - | | Chiles Center · Portland, OR |
| 30 | Thu Feb 23 | vsPepperdine | W91-82 | 22-8 | .733 | - | | Leavey Center · Santa Clara, CA |
| 31 | Sat Feb 25 | atSan Diego | W81-63 | 23-8 | .742 | - | | Jenny Craig Pavilion · San Diego, CA |
| 32 | Sun Mar 5 | vsSan Francisco | L87-93 (2OT) | 23-9 | .719 | - | ESPN2 | Orleans Arena · Las Vegas, NV |
| 33 | Wed Mar 15 | atSam Houston | L56-58 | 23-10 | .697 | - | | Leavey Center · Santa Clara, CA |
