| 1 | Tue Nov 4 | vs TBD | W83-53 | 1-0 | 1.000 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 2 | Fri Nov 7 | vsMcNeese | W79-67 | 2-0 | 1.000 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 3 | Mon Nov 10 | atXavier | W87-68 | 3-0 | 1.000 | - | FS1 | Cintas Center · Cincinnati, OH |
| 4 | Sat Nov 15 | vsNevada | W98-83 | 4-0 | 1.000 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 5 | Tue Nov 18 | vsIdaho St | W64-55 | 5-0 | 1.000 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 6 | Fri Nov 21 | vsLouisiana | W80-43 | 6-0 | 1.000 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 7 | Thu Nov 27 | atSaint Louis | L70-71 | 6-1 | .857 | - | CBSSN | Chaifetz Arena · St. Louis, MO |
| 8 | Fri Nov 28 | vsMinnesota | W86-75 | 7-1 | .875 | - | truTV | Leavey Center · Santa Clara, CA |
| 9 | Wed Dec 3 | vsUtah Tech | W90-80 | 8-1 | .889 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 10 | Sat Dec 6 | atNew Mexico | L71-98 | 8-2 | .800 | - | | The Pit · Albuquerque, NM |
| 11 | Sat Dec 13 | vsArizona St | L79-82 | 8-3 | .727 | - | TNT | Leavey Center · Santa Clara, CA |
| 12 | Wed Dec 17 | vsNorth Texas | W63-60 | 9-3 | .750 | - | | Leavey Center · Santa Clara, CA |
| 13 | Sat Dec 20 | vsLoyola Chicago | L78-80 | 9-4 | .692 | - | | Leavey Center · Santa Clara, CA |
| 14 | Sun Dec 28 | atOregon St | W102-64 | 10-4 | .714 | - | ESPN+ | Gill Coliseum · Corvallis, OR |
| 15 | Tue Dec 30 | atPortland | W92-85 | 11-4 | .733 | - | ESPN+ | Chiles Center · Portland, OR |
| 16 | Fri Jan 2 | vsPepperdine | W82-63 | 12-4 | .750 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 17 | Sun Jan 4 | vsSan Diego | W98-70 | 13-4 | .765 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 18 | Thu Jan 8 | at8Gonzaga | L77-89 | 13-5 | .722 | - | ESPN2 | McCarthey Athletic Center · Spokane, WA |
| 19 | Sat Jan 10 | vsLMU | W103-72 | 14-5 | .737 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 20 | Wed Jan 14 | vsPacific | W85-69 | 15-5 | .750 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 21 | Sat Jan 17 | vsSaint Mary's | W62-54 | 16-5 | .762 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 22 | Sat Jan 24 | atSan Diego | W85-73 | 17-5 | .773 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 23 | Wed Jan 28 | vsSan Francisco | W88-73 | 18-5 | .783 | - | CBSSN | Leavey Center · Santa Clara, CA |
| 24 | Sat Jan 31 | atLMU | W104-73 | 19-5 | .792 | - | ESPN+ | Gersten Pavilion · Los Angeles, CA |
| 25 | Wed Feb 4 | atPacific | W71-56 | 20-5 | .800 | - | ESPN+ | Alex G. Spanos Center · Stockton, CA |
| 26 | Sat Feb 7 | atWashington St | W96-92 | 21-5 | .808 | - | ESPN+ | Friel Court at Beasley Coliseum · Pullman, WA |
| 27 | Wed Feb 11 | vsSeattle U | W84-72 | 22-5 | .815 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 28 | Sat Feb 14 | vs12Gonzaga | L86-94 | 22-6 | .786 | - | ESPN | Leavey Center · Santa Clara, CA |
| 29 | Sat Feb 21 | atSan Francisco | W94-73 | 23-6 | .793 | - | CBSSN | War Memorial at the Sobrato Center · San Francisco, CA |
| 30 | Wed Feb 25 | atSaint Mary's | L67-86 | 23-7 | .767 | - | CBSSN | University Credit Union Pavilion · Moraga, CA |
| 31 | Sat Feb 28 | vsOregon St | W93-72 | 24-7 | .774 | - | CBSSN | Leavey Center · Santa Clara, CA |
