| 1 | Tue Nov 5 | at San Diego | W76-73 | 1-0 | 1.000 | - | | Jenny Craig Pavilion · San Diego, CA |
| 2 | Sat Nov 9 | atPepperdine | L73-77 | 1-1 | .500 | - | | Firestone Fieldhouse · Malibu, CA |
| 3 | Tue Nov 12 | vsTBD | W98-52 | 2-1 | .667 | - | | Bren Events Center · Irvine, CA |
| 4 | Fri Nov 15 | atBoise St | W69-60 | 3-1 | .750 | - | | ExtraMile Arena · Boise, ID |
| 5 | Mon Nov 18 | at23Colorado | L53-69 | 3-2 | .600 | - | PACN | CU Events Center · Boulder, CO |
| 6 | Thu Nov 21 | atTCU | L58-59 | 3-3 | .500 | - | | Schollmaier Arena · Fort Worth, TX |
| 7 | Sun Nov 24 | atDetroit Mercy | L74-86 | 3-4 | .429 | - | | Calihan Hall · Detroit, MI |
| 8 | Tue Nov 26 | vsLouisiana | W92-67 | 4-4 | .500 | - | | Bren Events Center · Irvine, CA |
| 9 | Sat Nov 30 | vsE Michigan | W77-56 | 5-4 | .556 | - | | Bren Events Center · Irvine, CA |
| 10 | Sat Dec 7 | vsCA Baptist | L60-68 | 5-5 | .500 | - | | Bren Events Center · Irvine, CA |
| 11 | Sat Dec 14 | vsTBD | W120-63 | 6-5 | .545 | - | | Bren Events Center · Irvine, CA |
| 12 | Mon Dec 16 | vsKent State | W74-68 | 7-5 | .583 | - | | Don Haskins Center · El Paso, TX |
| 13 | Tue Dec 17 | atUTEP | L61-67 | 7-6 | .538 | - | | Don Haskins Center · El Paso, TX |
| 14 | Fri Dec 20 | atUIC | L67-76 | 7-7 | .500 | - | | Credit Union 1 Arena · Chicago, IL |
| 15 | Sat Dec 28 | vsPacific | W69-56 | 8-7 | .533 | - | | Bren Events Center · Irvine, CA |
| 16 | Sat Jan 4 | atHarvard | L73-77 | 8-8 | .500 | - | | Lavietes Pavilion · Cambridge, MA |
| 17 | Sat Jan 11 | vsHawai'i | W74-60 | 9-8 | .529 | - | | Bren Events Center · Irvine, CA |
| 18 | Wed Jan 15 | atFullerton | W74-61 | 10-8 | .556 | - | | Titan Gym · Fullerton, CA |
| 19 | Sat Jan 18 | vsUC Riverside | W69-53 | 11-8 | .579 | - | | Bren Events Center · Irvine, CA |
| 20 | Wed Jan 22 | atLong Beach St | L56-63 | 11-9 | .550 | - | | Walter Pyramid · Long Beach, CA |
| 21 | Sat Jan 25 | vsCal Poly | W74-67 | 12-9 | .571 | - | | Bren Events Center · Irvine, CA |
| 22 | Thu Jan 30 | atUC Davis | W80-65 | 13-9 | .591 | - | | University Credit Union Center · Davis, CA |
| 23 | Sat Feb 1 | vsFullerton | W91-61 | 14-9 | .609 | - | | Bren Events Center · Irvine, CA |
| 24 | Thu Feb 6 | vsUC Davis | W83-72 | 15-9 | .625 | - | | Bren Events Center · Irvine, CA |
| 25 | Sat Feb 8 | atUCSB | L61-64 | 15-10 | .600 | - | ESPNU | The Thunderdome · Santa Barbara, CA |
| 26 | Wed Feb 12 | atUC Riverside | W63-59 | 16-10 | .615 | - | | SRC Arena · Riverside, CA |
| 27 | Sat Feb 15 | atHawai'i | W70-63 | 17-10 | .630 | - | ESPN2 | Stan Sheriff Center · Honolulu, HI |
| 28 | Wed Feb 19 | vsLong Beach St | W70-55 | 18-10 | .643 | - | | Bren Events Center · Irvine, CA |
| 29 | Sat Feb 22 | atCSU Northridge | W87-64 | 19-10 | .655 | - | | Premier America Credit Union Arena · Northridge, CA |
| 30 | Thu Feb 27 | atCal Poly | W82-76 | 20-10 | .667 | - | ESPNU | Robert A. Mott Athletics Center · San Luis Obispo, CA |
| 31 | Sat Feb 29 | vsUCSB | W69-58 | 21-10 | .677 | - | | Bren Events Center · Irvine, CA |
| 32 | Wed Mar 4 | vsCSU Northridge | L70-72 | 21-11 | .656 | - | | Bren Events Center · Irvine, CA |
