| 1 | Mon Nov 6 | vs TBD | W78-50 | 1-0 | 1.000 | - | | Lavietes Pavilion · Cambridge, MA |
| 2 | Fri Nov 10 | at Rice | W89-76 | 2-0 | 1.000 | - | | Tudor Fieldhouse · Houston, TX |
| 3 | Tue Nov 14 | vs Northeastern | W80-56 | 3-0 | 1.000 | - | | Lavietes Pavilion · Cambridge, MA |
| 4 | Fri Nov 17 | at UMass | W78-75 (OT) | 4-0 | 1.000 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 5 | Sat Nov 18 | at Boston College | L64-73 | 4-1 | .800 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 6 | Wed Nov 22 | at Colgate | W76-70 | 5-1 | .833 | - | | Cotterell Court · Hamilton, NY |
| 7 | Sun Nov 26 | at Indiana | L76-89 | 5-2 | .714 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 8 | Wed Nov 29 | vs American | W80-75 | 6-2 | .750 | - | | Lavietes Pavilion · Cambridge, MA |
| 9 | Sat Dec 2 | at Loyola Chicago | L53-75 | 6-3 | .667 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 10 | Fri Dec 8 | vs Army | W70-64 | 7-3 | .700 | - | | Lavietes Pavilion · Cambridge, MA |
| 11 | Thu Dec 21 | vs Holy Cross | W74-72 | 8-3 | .727 | - | | Lavietes Pavilion · Cambridge, MA |
| 12 | Sat Dec 30 | vs Iona | L60-69 | 8-4 | .667 | - | | Lavietes Pavilion · Cambridge, MA |
| 13 | Tue Jan 2 | vs Albany | W76-71 | 9-4 | .692 | - | | Lavietes Pavilion · Cambridge, MA |
| 14 | Sat Jan 6 | at Princeton | L58-89 | 9-5 | .643 | - | | Jadwin Gymnasium · Princeton, NJ |
| 15 | Mon Jan 15 | vs Brown | L72-74 | 9-6 | .600 | - | | Lavietes Pavilion · Cambridge, MA |
| 16 | Sat Jan 20 | at Penn | W70-61 | 10-6 | .625 | - | ESPNU | The Palestra · Philadelphia, PA |
| 17 | Sat Jan 27 | vs Yale | L65-78 | 10-7 | .588 | - | | Lavietes Pavilion · Cambridge, MA |
| 18 | Fri Feb 2 | vs Columbia | W62-59 | 11-7 | .611 | - | | Lavietes Pavilion · Cambridge, MA |
| 19 | Sat Feb 3 | vs Cornell | L76-89 | 11-8 | .579 | - | | Lavietes Pavilion · Cambridge, MA |
| 20 | Sat Feb 10 | vs Dartmouth | W77-59 | 12-8 | .600 | - | | Lavietes Pavilion · Cambridge, MA |
| 21 | Fri Feb 16 | atCornell | L62-75 | 12-9 | .571 | - | | Newman Arena · Ithaca, NY |
| 22 | Sat Feb 17 | atColumbia | W80-75 | 13-9 | .591 | - | | Francis S. Levien Gymnasium · New York, NY |
| 23 | Fri Feb 23 | vsPrinceton | L53-66 | 13-10 | .565 | - | | Lavietes Pavilion · Cambridge, MA |
| 24 | Sat Feb 24 | vsPenn | W74-70 | 14-10 | .583 | - | | Lavietes Pavilion · Cambridge, MA |
| 25 | Fri Mar 1 | atBrown | L68-71 (OT) | 14-11 | .560 | - | | Pizzitola Sports Center · Providence, RI |
| 26 | Sat Mar 2 | atYale | L60-80 | 14-12 | .538 | - | | John J. Lee Amphitheater · New Haven, CT |
| 27 | Tue Mar 5 | atDartmouth | L69-76 | 14-13 | .519 | - | | Edward Leede Arena · Hanover, NH |
