| 1 | Tue Nov 5 | at Stony Brook | W74-69 (OT) | 1-0 | 1.000 | - | | Island FCU Arena · Stony Brook, NY |
| 2 | Fri Nov 8 | vsTBD | W94-37 | 2-0 | 1.000 | - | | John J. Lee Amphitheater · New Haven, CT |
| 3 | Mon Nov 11 | atSan Francisco | L79-84 (OT) | 2-1 | .667 | - | | War Memorial at the Sobrato Center · San Francisco, CA |
| 4 | Sun Nov 17 | atOklahoma St | L57-64 | 2-2 | .500 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 5 | Wed Nov 20 | vsSiena | W100-89 (3OT) | 3-2 | .600 | - | | John J. Lee Amphitheater · New Haven, CT |
| 6 | Sat Nov 23 | atPenn State | L56-58 | 3-3 | .500 | - | | Bryce Jordan Center · University Park, PA |
| 7 | Mon Nov 25 | vsW Michigan | W73-51 | 4-3 | .571 | - | ESPNU | John J. Lee Amphitheater · New Haven, CT |
| 8 | Tue Nov 26 | atBucknell | W81-61 | 5-3 | .625 | - | ESPNU | Sojka Pavilion · Lewisburg, PA |
| 9 | Sun Dec 1 | vsVermont | W65-52 | 6-3 | .667 | - | | John J. Lee Amphitheater · New Haven, CT |
| 10 | Wed Dec 4 | atAlbany | W61-52 | 7-3 | .700 | - | | SEFCU Arena · Albany, NY |
| 11 | Sat Dec 7 | atLehigh | W78-65 | 8-3 | .727 | - | | Stabler Arena · Bethlehem, PA |
| 12 | Wed Dec 11 | atUMass | W83-80 (OT) | 9-3 | .750 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 13 | Sun Dec 22 | atClemson | W54-45 | 10-3 | .769 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 14 | Mon Dec 30 | atUNC | L67-70 | 10-4 | .714 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 15 | Sun Jan 12 | vsTBD | W108-58 | 11-4 | .733 | - | | John J. Lee Amphitheater · New Haven, CT |
| 16 | Fri Jan 17 | vsBrown | W70-56 | 12-4 | .750 | - | | John J. Lee Amphitheater · New Haven, CT |
| 17 | Mon Jan 20 | atHoward | W89-75 | 13-4 | .765 | - | | Burr Gymnasium · Washington, D.C. |
| 18 | Fri Jan 24 | atBrown | W73-62 | 14-4 | .778 | - | ESPNU | Pizzitola Sports Center · Providence, RI |
| 19 | Fri Jan 31 | vsColumbia | W93-62 | 15-4 | .789 | - | | John J. Lee Amphitheater · New Haven, CT |
| 20 | Sat Feb 1 | vsCornell | W86-71 | 16-4 | .800 | - | | John J. Lee Amphitheater · New Haven, CT |
| 21 | Fri Feb 7 | vsHarvard | L77-78 | 16-5 | .762 | - | ESPNU | John J. Lee Amphitheater · New Haven, CT |
| 22 | Sat Feb 8 | vsDartmouth | W75-57 | 17-5 | .773 | - | | John J. Lee Amphitheater · New Haven, CT |
| 23 | Fri Feb 14 | atPrinceton | W88-64 | 18-5 | .783 | - | ESPNEWS | Jadwin Gymnasium · Princeton, NJ |
| 24 | Sat Feb 15 | atPenn | L61-69 | 18-6 | .750 | - | | The Palestra · Philadelphia, PA |
| 25 | Fri Feb 21 | atCornell | W81-80 (2OT) | 19-6 | .760 | - | | Newman Arena · Ithaca, NY |
| 26 | Sat Feb 22 | atColumbia | W83-65 | 20-6 | .769 | - | | Francis S. Levien Gymnasium · New York, NY |
| 27 | Fri Feb 28 | vsPenn | W76-73 | 21-6 | .778 | - | | John J. Lee Amphitheater · New Haven, CT |
| 28 | Sat Feb 29 | vsPrinceton | W66-63 | 22-6 | .786 | - | | John J. Lee Amphitheater · New Haven, CT |
| 29 | Fri Mar 6 | atDartmouth | W72-61 | 23-6 | .793 | - | | Edward Leede Arena · Hanover, NH |
| 30 | Sat Mar 7 | atHarvard | L69-83 | 23-7 | .767 | - | | Lavietes Pavilion · Cambridge, MA |
