| 1 | Mon Nov 6 | vs TBD | W102-53 | 1-0 | 1.000 | - | | John J. Lee Amphitheater · New Haven, CT |
| 2 | Fri Nov 10 | at#11Gonzaga | L71-86 | 1-1 | .500 | - | | McCarthey Athletic Center · Spokane, WA |
| 3 | Sun Nov 12 | atLMU | W83-80 | 2-1 | .667 | - | | Gersten Pavilion · Los Angeles, CA |
| 4 | Fri Nov 17 | vsColgate | W68-50 | 3-1 | .750 | - | | John J. Lee Amphitheater · New Haven, CT |
| 5 | Sat Nov 18 | atWeber St | L65-75 (OT) | 3-2 | .600 | - | | Dee Events Center · Ogden, UT |
| 6 | Sun Nov 19 | atGardner-Webb | W71-70 (OT) | 4-2 | .667 | - | | Paul Porter Arena · Boiling Springs, NC |
| 7 | Sun Nov 26 | atRhode Island | L72-76 | 4-3 | .571 | - | | Ryan Center · Kingston, RI |
| 8 | Wed Nov 29 | vsStony Brook | W79-71 | 5-3 | .625 | - | | John J. Lee Amphitheater · New Haven, CT |
| 9 | Sat Dec 2 | atVermont | L65-66 | 5-4 | .556 | - | | Patrick Gymnasium · Burlington, VT |
| 10 | Wed Dec 6 | vsFairfield | L71-75 | 5-5 | .500 | - | | John J. Lee Amphitheater · New Haven, CT |
| 11 | Fri Dec 8 | vsTBD | W95-36 | 6-5 | .545 | - | | John J. Lee Amphitheater · New Haven, CT |
| 12 | Mon Dec 11 | atQuinnipiac | W73-66 | 7-5 | .583 | - | | M&T Bank Arena · Hamden, CT |
| 13 | Fri Dec 22 | at#2Kansas | L60-75 | 7-6 | .538 | - | | Allen Fieldhouse · Lawrence, KS |
| 14 | Sat Dec 30 | atSanta Clara | W66-58 | 8-6 | .571 | - | | Leavey Center · Santa Clara, CA |
| 15 | Wed Jan 3 | atHoward | W86-78 (OT) | 9-6 | .600 | - | | Burr Gymnasium · Washington, D.C. |
| 16 | Tue Jan 9 | atBrown | W80-70 | 10-6 | .625 | - | ESPNU | Pizzitola Sports Center · Providence, RI |
| 17 | Mon Jan 15 | vsColumbia | W89-70 | 11-6 | .647 | - | | John J. Lee Amphitheater · New Haven, CT |
| 18 | Sat Jan 20 | atDartmouth | W76-51 | 12-6 | .667 | - | | Edward Leede Arena · Hanover, NH |
| 19 | Sat Jan 27 | atHarvard | W78-65 | 13-6 | .684 | - | | Lavietes Pavilion · Cambridge, MA |
| 20 | Fri Feb 2 | vsPrinceton | W70-64 | 14-6 | .700 | - | ESPNU | John J. Lee Amphitheater · New Haven, CT |
| 21 | Sat Feb 3 | vsPenn | W74-58 | 15-6 | .714 | - | | John J. Lee Amphitheater · New Haven, CT |
| 22 | Sat Feb 10 | vsCornell | W80-78 | 16-6 | .727 | - | | John J. Lee Amphitheater · New Haven, CT |
| 23 | Fri Feb 16 | atPenn | W76-62 | 17-6 | .739 | - | | The Palestra · Philadelphia, PA |
| 24 | Sat Feb 17 | atPrinceton | L62-73 | 17-7 | .708 | - | ESPN2 | Jadwin Gymnasium · Princeton, NJ |
| 25 | Fri Feb 23 | atCornell | L62-65 | 17-8 | .680 | - | | Newman Arena · Ithaca, NY |
| 26 | Sat Feb 24 | atColumbia | W84-76 | 18-8 | .692 | - | | Francis S. Levien Gymnasium · New York, NY |
| 27 | Fri Mar 1 | vsDartmouth | W80-56 | 19-8 | .704 | - | | John J. Lee Amphitheater · New Haven, CT |
| 28 | Sat Mar 2 | vsHarvard | W80-60 | 20-8 | .714 | - | | John J. Lee Amphitheater · New Haven, CT |
| 29 | Sat Mar 9 | vsBrown | L81-84 (OT) | 20-9 | .690 | - | | John J. Lee Amphitheater · New Haven, CT |
| 30 | Sat Mar 16 | vsCornell | W69-57 | 21-9 | .700 | - | ESPNEWS | John J. Lee Amphitheater · New Haven, CT |
| 31 | Sun Mar 17 | vsBrown | W62-61 | 22-9 | .710 | - | ESPN2 | John J. Lee Amphitheater · New Haven, CT |
| 32 | Fri Mar 22 | at#4Auburn | W78-76 | 23-9 | .719 | #13 | TNT | Neville Arena · Auburn, AL |
| 33 | Sun Mar 24 | at#5SDSU | L57-85 | 23-10 | .697 | #13 | TBS | Viejas Arena · San Diego, CA |
