| 2 | Sat Nov 28 | at Liberty | L62-78 | 0-1 | .000 | - | ESPNEWS | Liberty Arena · Lynchburg, VA |
| 3 | Sun Nov 29 | at Tulsa | W69-58 | 1-1 | .500 | - | ESPN2 | Donald W. Reynolds Center · Tulsa, OK |
| 4 | Sat Dec 5 | at #10Houston | L67-77 | 1-2 | .333 | - | | Fertitta Center · Houston, TX |
| 8 | Tue Dec 29 | at Kentucky | PPD | 6-15 | .286 | - | ESPN2 | Rupp Arena · Lexington, KY |
| 9 | Sat Jan 2 | vs FAMU | W78-71 | 2-2 | .500 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 10 | Wed Jan 6 | vs Texas A&M | W78-54 | 3-2 | .600 | - | ESPNU | Colonial Life Arena · Columbia, SC |
| 11 | Sat Jan 16 | at LSU | L80-85 | 3-3 | .500 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 12 | Tue Jan 19 | at #19Missouri | L70-81 | 3-4 | .429 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 13 | Sat Jan 23 | vs Auburn | L86-109 | 3-5 | .375 | - | ESPN2 | Colonial Life Arena · Columbia, SC |
| 14 | Wed Jan 27 | vs Georgia | W83-59 | 4-5 | .444 | - | ESPN2 | Colonial Life Arena · Columbia, SC |
| 15 | Sat Jan 30 | at Vanderbilt | L81-93 | 4-6 | .400 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 16 | Wed Feb 3 | at #22Florida | W72-66 | 5-6 | .455 | - | SEC Network | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 17 | Sat Feb 6 | vs Mississippi St | L59-75 | 5-7 | .417 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 18 | Tue Feb 9 | vs #11Alabama | L78-81 | 5-8 | .385 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 19 | Sat Feb 13 | vs Ole Miss | L74-81 | 5-9 | .357 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 20 | Wed Feb 17 | at #19Tennessee | L73-93 | 5-10 | .333 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 21 | Sat Feb 20 | vs#20Missouri | L78-93 | 5-11 | .313 | - | ESPN2 | Colonial Life Arena · Columbia, SC |
| 22 | Wed Feb 24 | atMississippi St | L48-69 | 5-12 | .294 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 23 | Sat Feb 27 | atGeorgia | W91-70 | 6-12 | .333 | - | SEC Network | Stegeman Coliseum · Athens, GA |
| 24 | Tue Mar 2 | vs #12Arkansas | L73-101 | 6-13 | .316 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 25 | Sat Mar 6 | atKentucky | L64-92 | 6-14 | .300 | - | ESPN | Rupp Arena · Lexington, KY |
| 26 | Thu Mar 11 | atOle Miss | L59-76 | 6-15 | .286 | - | SEC Network | SJB Pavilion · Oxford, MS |
TBD
Wofford
#24Clemson
SC State