| 1 | Tue Nov 4 | vs NC A&T | 7:00 PM | 7-25 | .219 | - | | Colonial Life Arena · Columbia, SC |
| 2 | Sun Nov 9 | vsSouthern Miss | 6:30 PM | 11-22 | .333 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 3 | Wed Nov 12 | vsPresbyterian | 7:00 PM | 14-19 | .424 | - | | Colonial Life Arena · Columbia, SC |
| 4 | Tue Nov 18 | vsRadford | 7:00 PM | 20-13 | .606 | - | | Colonial Life Arena · Columbia, SC |
| 5 | Fri Nov 21 | atButler | 2:00 PM | 15-20 | .429 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 6 | Sun Nov 23 | atNorthwestern | 5:00 PM | 17-16 | .515 | - | | Welsh-Ryan Arena · Evanston, IL |
| 7 | Fri Nov 28 | vsCharleston So | 4:00 PM | 10-22 | .313 | - | | Colonial Life Arena · Columbia, SC |
| 8 | Tue Dec 2 | vsVirginia Tech | 7:00 PM | 13-19 | .406 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 9 | Sat Dec 6 | vsStetson | 2:00 PM | 8-24 | .250 | - | | Colonial Life Arena · Columbia, SC |
| 10 | Sat Dec 13 | vsThe Citadel | 7:00 PM | 5-25 | .167 | - | | Colonial Life Arena · Columbia, SC |
| 11 | Tue Dec 16 | atClemson | 7:00 PM | 27-7 | .794 | - | ESPN2 | Littlejohn Coliseum · Clemson, SC |
| 12 | Mon Dec 22 | vsSC State | 4:00 PM | 20-13 | .606 | - | | Colonial Life Arena · Columbia, SC |
| 13 | Tue Dec 30 | vsAlbany | 6:00 PM | 17-16 | .515 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 14 | Sat Jan 3 | vsVanderbilt | 2:00 PM | 20-13 | .606 | - | ESPNU | Colonial Life Arena · Columbia, SC |
| 15 | Tue Jan 6 | atLSU | 7:00 PM | 14-18 | .438 | - | ESPNU | Pete Maravich Assembly Center · Baton Rouge, LA |
| 16 | Sat Jan 10 | vsGeorgia | 2:00 PM | 20-13 | .606 | - | ESPN2 | Colonial Life Arena · Columbia, SC |
| 17 | Wed Jan 14 | at#14Arkansas | 9:00 PM | 22-14 | .611 | - | SEC Network | Bud Walton Arena · Fayetteville, AR |
| 18 | Sat Jan 17 | at#20Auburn | 6:00 PM | 32-6 | .842 | - | SEC Network | Neville Arena · Auburn, AL |
| 19 | Tue Jan 20 | vsOklahoma | 7:00 PM | 20-14 | .588 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 20 | Sat Jan 24 | atTexas A&M | 3:30 PM | 23-11 | .676 | - | SEC Network | Reed Arena · College Station, TX |
| 21 | Wed Jan 28 | vs#3Florida | 9:00 PM | 36-4 | .900 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 22 | Sat Jan 31 | vsLSU | 6:00 PM | 14-18 | .438 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 23 | Tue Feb 3 | atTexas | 7:00 PM | 19-16 | .543 | - | SEC Network | Moody Center · Austin, TX |
| 24 | Sat Feb 7 | vsMissouri | 1:00 PM | 22-12 | .647 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 25 | Sat Feb 14 | at#15Alabama | 8:30 PM | 28-9 | .757 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 26 | Tue Feb 17 | at#3Florida | 7:00 PM | 36-4 | .900 | - | SEC Network | O'Connell Center · Gainesville, FL |
| 27 | Sat Feb 21 | vsMississippi St | 1:00 PM | 21-13 | .618 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 28 | Tue Feb 24 | vs#9Kentucky | 7:00 PM | 24-12 | .667 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 29 | Sat Feb 28 | atGeorgia | 3:30 PM | 20-13 | .606 | - | SEC Network | Stegeman Coliseum · Athens, GA |
| 30 | Tue Mar 3 | vs#18Tennessee | 6:00 PM | 30-8 | .789 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 31 | Sat Mar 7 | atOle Miss | 1:00 PM | 24-12 | .667 | - | SEC Network | SJB Pavilion · Oxford, MS |
