| 1 | Mon Nov 3 | vs North Dakota | W91-62 | 1-0 | 1.000 | #15 | SECN+ | Coleman Coliseum · Tuscaloosa, AL |
| 2 | Sat Nov 8 | at5St John's | W103-96 | 2-0 | 1.000 | #15 | FS1 | Carnesecca Arena · Queens, NY |
| 3 | Thu Nov 13 | vs2Purdue | L80-87 | 2-1 | .667 | #8 | ESPN2 | Coleman Coliseum · Tuscaloosa, AL |
| 4 | Wed Nov 19 | at8Illinois | W90-86 | 3-1 | .750 | #11 | FS1 | State Farm Center · Champaign, IL |
| 5 | Mon Nov 24 | vs12Gonzaga | L85-95 | 3-2 | .600 | #8 | TNT | Coleman Coliseum · Tuscaloosa, AL |
| 6 | Tue Nov 25 | vsUNLV | W115-76 | 4-2 | .667 | #8 | truTV | Coleman Coliseum · Tuscaloosa, AL |
| 7 | Wed Nov 26 | vsMaryland | W105-72 | 5-2 | .714 | #8 | TNT | Coleman Coliseum · Tuscaloosa, AL |
| 8 | Wed Dec 3 | vsClemson | W90-84 | 6-2 | .750 | #12 | ESPNU | Coleman Coliseum · Tuscaloosa, AL |
| 9 | Sun Dec 7 | vsUTSA | W97-55 | 7-2 | .778 | #12 | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 10 | Sat Dec 13 | vs1Arizona | L75-96 | 7-3 | .700 | #12 | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 11 | Wed Dec 17 | vsSouth Florida | W104-93 | 8-3 | .727 | #16 | SECN+ | Coleman Coliseum · Tuscaloosa, AL |
| 12 | Sun Dec 21 | vsKennesaw St | W92-81 | 9-3 | .750 | #16 | SECN+ | Coleman Coliseum · Tuscaloosa, AL |
| 13 | Mon Dec 29 | vsYale | W102-78 | 10-3 | .769 | #14 | SECN+ | Coleman Coliseum · Tuscaloosa, AL |
| 14 | Sat Jan 3 | vsKentucky | W89-74 | 11-3 | .786 | #14 | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 15 | Wed Jan 7 | at11Vanderbilt | L90-96 | 11-4 | .733 | #13 | ESPN2 | Memorial Gymnasium (TN) · Nashville, TN |
| 16 | Sat Jan 10 | vsTexas | L88-92 | 11-5 | .688 | #13 | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 17 | Tue Jan 13 | atMississippi St | W97-82 | 12-5 | .706 | #18 | SEC Network | Humphrey Coliseum · Starkville, MS |
| 18 | Sat Jan 17 | atOklahoma | W83-81 | 13-5 | .722 | #18 | SEC Network | Lloyd Noble Center · Norman, OK |
| 19 | Sat Jan 24 | vsTennessee | L73-79 | 13-6 | .684 | #17 | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 20 | Tue Jan 27 | vsMissouri | W90-64 | 14-6 | .700 | #23 | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 21 | Sun Feb 1 | at19Florida | L77-100 | 14-7 | .667 | #23 | ABC | O'Connell Center · Gainesville, FL |
| 22 | Wed Feb 4 | vsTexas A&M | W100-97 | 15-7 | .682 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 23 | Sat Feb 7 | atAuburn | W96-92 | 16-7 | .696 | - | ESPN2 | Neville Arena · Auburn, AL |
| 24 | Wed Feb 11 | atOle Miss | W93-74 | 17-7 | .708 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 25 | Sat Feb 14 | vsSouth Carolina | W89-75 | 18-7 | .720 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 26 | Wed Feb 18 | vs20Arkansas | W117-115 (2OT) | 19-7 | .731 | #25 | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 27 | Sat Feb 21 | atLSU | W90-83 | 20-7 | .741 | #25 | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 28 | Wed Feb 25 | vsMississippi St | W100-75 | 21-7 | .750 | #17 | ESPNU | Coleman Coliseum · Tuscaloosa, AL |
| 29 | Sat Feb 28 | at22Tennessee | W71-69 | 22-7 | .759 | #17 | ESPN | Thompson-Boling Arena · Knoxville, TN |
