| 1 | Wed Nov 25 | vs Saint Mary's | W73-56 | 1-0 | 1.000 | - | ESPN2 | FedExForum · Memphis, TN |
| 2 | Thu Nov 26 | vsWestern KY | L69-75 | 1-1 | .500 | - | ESPN | FedExForum · Memphis, TN |
| 3 | Fri Nov 27 | vsVCU | L59-70 | 1-2 | .333 | - | ESPN2 | FedExForum · Memphis, TN |
| 4 | Wed Dec 2 | vsArkansas St | W83-54 | 2-2 | .500 | - | | FedExForum · Memphis, TN |
| 5 | Fri Dec 4 | vsC Arkansas | W85-68 | 3-2 | .600 | - | | FedExForum · Memphis, TN |
| 7 | Tue Dec 8 | vsMiss Valley St | W94-57 | 4-2 | .667 | - | | FedExForum · Memphis, TN |
| 8 | Sat Dec 12 | atAuburn | L71-74 | 4-3 | .571 | - | ESPNU | State Farm Arena · Atlanta, GA |
| 9 | Wed Dec 16 | atTulane | W80-74 | 5-3 | .625 | - | ESPN2 | Devlin Fieldhouse · New Orleans, LA |
| 10 | Mon Dec 21 | vsTulsa | L49-56 | 5-4 | .556 | - | ESPN2 | FedExForum · Memphis, TN |
| 11 | Tue Dec 29 | vsSouth Florida | W58-57 | 6-4 | .600 | - | ESPN2 | FedExForum · Memphis, TN |
| 14 | Thu Jan 14 | vsSMU | PPD | 20-8 | .714 | - | | FedExForum · Memphis, TN |
| 15 | Sun Jan 17 | atTulsa | L57-58 | 6-5 | .545 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 16 | Thu Jan 21 | vsWichita St | W72-52 | 7-5 | .583 | - | ESPN2 | FedExForum · Memphis, TN |
| 17 | Sun Jan 24 | atE Carolina | W80-53 | 8-5 | .615 | - | ESPN2 | Williams Arena at Minges Coliseum · Greenville, NC |
| 18 | Tue Jan 26 | vsSMU | W76-72 | 9-5 | .643 | - | ESPNU | FedExForum · Memphis, TN |
| 19 | Thu Jan 28 | atSMU | L65-67 | 9-6 | .600 | - | ESPN2 | Moody Coliseum · Dallas, TX |
| 20 | Mon Feb 1 | vsUCF | W96-69 | 10-6 | .625 | - | | FedExForum · Memphis, TN |
| 21 | Wed Feb 3 | vsUCF | W75-61 | 11-6 | .647 | - | | FedExForum · Memphis, TN |
| 22 | Sat Feb 6 | vsE Carolina | W66-59 | 12-6 | .667 | - | ESPN | FedExForum · Memphis, TN |
| 24 | Sun Feb 14 | at8Houston | PPD | 20-8 | .714 | - | | Fertitta Center · Houston, TX |
| 25 | Wed Feb 24 | vsTulane | W61-46 | 13-6 | .684 | - | | FedExForum · Memphis, TN |
| 26 | Sun Feb 28 | atCincinnati | W80-74 | 14-6 | .700 | - | ESPN | Fifth Third Arena · Cincinnati, OH |
| 27 | Tue Mar 2 | atSouth Florida | W73-52 | 15-6 | .714 | - | ESPNU | Yuengling Center · Tampa, FL |
| 28 | Sun Mar 7 | at9Houston | L64-67 | 15-7 | .682 | - | CBS | Fertitta Center · Houston, TX |
| 29 | Fri Mar 12 | vsUCF | W70-62 | 16-7 | .696 | - | ESPN2 | FedExForum · Memphis, TN |
| 30 | Sat Mar 13 | atHouston | L74-76 | 16-8 | .667 | - | ESPN2 | Fertitta Center · Houston, TX |
| 27 | Sat Mar 20 | vs4Dayton | W71-60 | 17-8 | .680 | #1 | ESPN | The Super Pit · Denton, TX |
| 28 | Thu Mar 25 | vs2Boise St | W59-56 | 18-8 | .692 | #1 | ESPN | The Super Pit · Denton, TX |
| 29 | Sat Mar 27 | at1Colorado St | W90-67 | 19-8 | .704 | #1 | ESPN | Moby Arena · Fort Collins, CO |
| 30 | Sun Mar 28 | vs4Mississippi St | W77-64 | 20-8 | .714 | #1 | ESPN | FedExForum · Memphis, TN |
