| 1 | Wed Nov 6 | at #18Ohio State | L56-64 | 0-1 | .000 | - | FS1 | Value City Arena · Columbus, OH |
| 2 | Mon Nov 11 | vs Drake | W81-59 | 1-1 | .500 | - | | Fifth Third Arena · Cincinnati, OH |
| 3 | Thu Nov 14 | vs Alabama A&M | W85-53 | 2-1 | .667 | - | | Fifth Third Arena · Cincinnati, OH |
| 4 | Fri Nov 22 | vs Illinois St | W66-65 | 3-1 | .750 | - | | Fifth Third Arena · Cincinnati, OH |
| 5 | Sun Nov 24 | at Bowling Green | L84-91 (OT) | 3-2 | .600 | - | | Stroh Center · Bowling Green, OH |
| 6 | Mon Nov 25 | vs Valparaiso | W81-77 (OT) | 4-2 | .667 | - | | Fifth Third Arena · Cincinnati, OH |
| 7 | Sat Nov 30 | vs UNLV | W72-65 (OT) | 5-2 | .714 | - | | Fifth Third Arena · Cincinnati, OH |
| 8 | Tue Dec 3 | vs Vermont | W82-73 | 6-2 | .750 | - | CBS | Fifth Third Arena · Cincinnati, OH |
| 9 | Sat Dec 7 | at Xavier | L66-73 | 6-3 | .667 | - | FS1 | Cintas Center · Cincinnati, OH |
| 10 | Sat Dec 14 | vs Colgate | L66-67 | 6-4 | .600 | - | | Fifth Third Arena · Cincinnati, OH |
| 11 | Wed Dec 18 | vs #21Tennessee | W78-66 | 7-4 | .636 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 12 | Sat Dec 21 | at Iowa | L70-77 | 7-5 | .583 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 13 | Wed Jan 1 | vs UConn | W67-51 | 8-5 | .615 | - | CBS | Fifth Third Arena · Cincinnati, OH |
| 14 | Sat Jan 4 | at Tulane | L71-76 | 8-6 | .571 | - | CBS | Devlin Fieldhouse · New Orleans, LA |
| 15 | Wed Jan 8 | vs Tulsa | W75-44 | 9-6 | .600 | - | ESPNU | Fifth Third Arena · Cincinnati, OH |
| 16 | Sat Jan 11 | at UCF | W68-54 | 10-6 | .625 | - | ESPN2 | Addition Financial Arena · Orlando, FL |
| 17 | Thu Jan 16 | at #22Memphis | L49-60 | 10-7 | .588 | - | ESPN | FedExForum · Memphis, TN |
| 18 | Sun Jan 19 | vs E Carolina | W82-57 | 11-7 | .611 | - | ESPNU | Fifth Third Arena · Cincinnati, OH |
| 19 | Wed Jan 22 | at Temple | W89-82 | 12-7 | .632 | - | ESPNEWS | Liacouras Center · Philadelphia, PA |
| 20 | Tue Jan 28 | vs SMU | W65-43 | 13-7 | .650 | - | ESPNEWS | Fifth Third Arena · Cincinnati, OH |
| 21 | Sat Feb 1 | vs #21Houston | W64-62 | 14-7 | .667 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 22 | Thu Feb 6 | at Wichita St | W80-79 | 15-7 | .682 | - | ESPN | Charles Koch Arena · Wichita, KS |
| 23 | Sun Feb 9 | atUConn | L71-72 (OT) | 15-8 | .652 | - | CBS | Gampel Pavilion · Storrs, CT |
| 24 | Thu Feb 13 | vsMemphis | W92-86 (OT) | 16-8 | .667 | - | ESPN | Fifth Third Arena · Cincinnati, OH |
| 25 | Sun Feb 16 | atE Carolina | W70-67 (OT) | 17-8 | .680 | - | CBS | Williams Arena at Minges Coliseum · Greenville, NC |
| 26 | Wed Feb 19 | vsUCF | L87-89 (2OT) | 17-9 | .654 | - | ESPNU | Fifth Third Arena · Cincinnati, OH |
| 27 | Sun Feb 23 | vsWichita St | W67-64 | 18-9 | .667 | - | ESPN | Fifth Third Arena · Cincinnati, OH |
| 28 | Sun Mar 1 | at#25Houston | L55-68 | 18-10 | .643 | - | ESPN | Fertitta Center · Houston, TX |
| 29 | Tue Mar 3 | at South Florida | W79-67 | 19-10 | .655 | - | ESPNU | Yuengling Center · Tampa, FL |
| 30 | Sat Mar 7 | vsTemple | W64-63 | 20-10 | .667 | - | CBS | Fifth Third Arena · Cincinnati, OH |
