| 1 | Wed Dec 2 | vs Lipscomb | W67-55 | 1-0 | 1.000 | - | | Fifth Third Arena · Cincinnati, OH |
| 2 | Sun Dec 6 | vs Xavier | L69-77 | 1-1 | .500 | - | ESPN | Fifth Third Arena · Cincinnati, OH |
| 3 | Wed Dec 9 | vs Furman | W78-73 | 2-1 | .667 | - | | Fifth Third Arena · Cincinnati, OH |
| 4 | Sat Dec 12 | at #12Tennessee | L56-65 | 2-2 | .500 | - | SEC Alternate | Thompson-Boling Arena · Knoxville, TN |
| 5 | Wed Dec 16 | vs South Florida | L71-74 | 2-3 | .400 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 6 | Sat Dec 19 | at Georgia | L68-83 | 2-4 | .333 | - | SEC Network | Stegeman Coliseum · Athens, GA |
| 7 | Tue Dec 22 | at UCF | L70-75 | 2-5 | .286 | - | | Addition Financial Arena · Orlando, FL |
| 8 | Sat Jan 2 | vs Tulsa | L66-70 | 2-6 | .250 | - | | Fifth Third Arena · Cincinnati, OH |
| 9 | Thu Jan 7 | at SMU | W76-69 | 3-6 | .333 | - | ESPNU | Moody Coliseum · Dallas, TX |
| 10 | Sun Jan 10 | at Wichita St | L76-82 | 3-7 | .300 | - | ESPN2 | Charles Koch Arena · Wichita, KS |
| 12 | Wed Jan 20 | at Temple | PPD | 12-11 | .522 | - | | Liacouras Center · Philadelphia, PA |
| 15 | Thu Feb 4 | atTemple | W63-60 | 4-7 | .364 | - | ESPN2 | Liacouras Center · Philadelphia, PA |
| 16 | Sun Feb 7 | at Tulane | W64-61 | 5-7 | .417 | - | | Devlin Fieldhouse · New Orleans, LA |
| 18 | Fri Feb 12 | vsTemple | W71-69 | 6-7 | .462 | - | | Fifth Third Arena · Cincinnati, OH |
| 19 | Sun Feb 14 | vsUCF | W69-68 | 7-7 | .500 | - | | Fifth Third Arena · Cincinnati, OH |
| 20 | Sun Feb 21 | at #6Houston | L52-90 | 7-8 | .467 | - | ESPN | Fertitta Center · Houston, TX |
| 21 | Wed Feb 24 | atTulsa | W70-69 | 8-8 | .500 | - | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
| 22 | Fri Feb 26 | vsTulane | W91-71 | 9-8 | .529 | - | | Fifth Third Arena · Cincinnati, OH |
| 23 | Sun Feb 28 | vs Memphis | L74-80 | 9-9 | .500 | - | ESPN | Fifth Third Arena · Cincinnati, OH |
| 24 | Thu Mar 4 | vs Vanderbilt | L64-78 | 9-10 | .474 | - | | Fifth Third Arena · Cincinnati, OH |
| 25 | Sun Mar 7 | at E Carolina | W82-69 | 10-10 | .500 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 26 | Fri Mar 12 | atSMU | W74-71 | 11-10 | .524 | - | ESPN2 | Moody Coliseum · Dallas, TX |
| 27 | Sat Mar 13 | atWichita St | W60-59 | 12-10 | .545 | - | ESPN2 | Charles Koch Arena · Wichita, KS |
| 28 | Sun Mar 14 | atHouston | L54-91 | 12-11 | .522 | - | ESPN | Fertitta Center · Houston, TX |
