| 1 | Mon Nov 7 | vs Bethune | W89-58 | 1-0 | 1.000 | - | ESPNU | Carver-Hawkeye Arena · Iowa City, IA |
| 2 | Fri Nov 11 | vsNC A&T | W112-71 | 2-0 | 1.000 | - | | Carver-Hawkeye Arena · Iowa City, IA |
| 3 | Wed Nov 16 | atSeton Hall | W83-67 | 3-0 | 1.000 | - | FS1 | Prudential Center · Newark, NJ |
| 4 | Mon Nov 21 | vsOmaha | W100-64 | 4-0 | 1.000 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 5 | Fri Nov 25 | atClemson | W74-71 | 5-0 | 1.000 | - | CBSSN | Littlejohn Coliseum · Clemson, SC |
| 6 | Sat Nov 26 | atTCU | L66-79 | 5-1 | .833 | - | CBSSN | Schollmaier Arena · Fort Worth, TX |
| 7 | Tue Nov 29 | vsGeorgia Tech | W81-65 | 6-1 | .857 | - | ESPN2 | Carver-Hawkeye Arena · Iowa City, IA |
| 8 | Tue Dec 6 | atDuke | L62-74 | 6-2 | .750 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 9 | Thu Dec 8 | vs20Iowa State | W75-56 | 7-2 | .778 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 10 | Sun Dec 11 | vsWisconsin | L75-78 (OT) | 7-3 | .700 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 11 | Sat Dec 17 | vsSE Missouri St | W106-75 | 8-3 | .727 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 12 | Wed Dec 21 | vsE Illinois | L83-92 | 8-4 | .667 | - | | Carver-Hawkeye Arena · Iowa City, IA |
| 13 | Thu Dec 29 | atNebraska | L50-66 | 8-5 | .615 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 14 | Sun Jan 1 | atPenn State | L79-83 | 8-6 | .571 | - | BTN | Bryce Jordan Center · University Park, PA |
| 15 | Thu Jan 5 | vs15Indiana | W91-89 | 9-6 | .600 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 16 | Sun Jan 8 | atRutgers | W76-65 | 10-6 | .625 | - | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 17 | Thu Jan 12 | vsMichigan | W93-84 (OT) | 11-6 | .647 | - | ESPN2 | Carver-Hawkeye Arena · Iowa City, IA |
| 18 | Sun Jan 15 | vsMaryland | W81-67 | 12-6 | .667 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 19 | Wed Jan 18 | vsNorthwestern | PPD | 19-14 | .576 | - | | Carver-Hawkeye Arena · Iowa City, IA |
| 20 | Sat Jan 21 | atOhio State | L77-93 | 12-7 | .632 | - | FOX | Value City Arena · Columbus, OH |
| 21 | Thu Jan 26 | atMichigan St | L61-63 | 12-8 | .600 | - | FS1 | Breslin Center · East Lansing, MI |
| 22 | Sun Jan 29 | vsRutgers | W93-82 | 13-8 | .619 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 23 | Tue Jan 31 | vsNorthwestern | W86-70 | 14-8 | .636 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 24 | Sat Feb 4 | vsIllinois | W81-79 | 15-8 | .652 | - | FOX | Carver-Hawkeye Arena · Iowa City, IA |
| 25 | Thu Feb 9 | at1Purdue | L73-87 | 15-9 | .625 | - | ESPN2 | Mackey Arena · West Lafayette, IN |
| 26 | Sun Feb 12 | atMinnesota | W68-56 | 16-9 | .640 | - | FS1 | Williams Arena · Minneapolis, MN |
| 27 | Thu Feb 16 | vsOhio State | W92-75 | 17-9 | .654 | - | ESPN2 | Carver-Hawkeye Arena · Iowa City, IA |
| 28 | Sun Feb 19 | atNorthwestern | L60-80 | 17-10 | .630 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 29 | Wed Feb 22 | atWisconsin | L52-64 | 17-11 | .607 | - | BTN | Kohl Center · Madison, WI |
| 30 | Sat Feb 25 | vsMichigan St | W112-106 (OT) | 18-11 | .621 | - | ESPN | Carver-Hawkeye Arena · Iowa City, IA |
| 31 | Tue Feb 28 | at15Indiana | W90-68 | 19-11 | .633 | - | ESPN2 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 32 | Sun Mar 5 | vsNebraska | L77-81 | 19-12 | .613 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 33 | Thu Mar 9 | vsOhio State | L69-73 | 19-13 | .594 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 34 | Thu Mar 16 | vs9Auburn | L75-83 | 19-14 | .576 | #8 | TNT | Carver-Hawkeye Arena · Iowa City, IA |
